{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:24:19Z","timestamp":1770823459538,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>AIMS: To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS: Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In the cases associated with pseudoangiomatous hyperplasia of mammary stroma, immunoreactivity for cytokeratins (CAM 5.2), vimentin, CD34, factor VIII related antigen, and the oestrogen and progesterone receptors were studied. RESULTS: Pseudoangiomatous hyperplasia of mammary stroma was found in 21 of 88 cases of gynaecomastia (23.8%). In all cases, the cells lining the spaces were positive for vimentin, whereas CAM 5.2 and factor VIII related antigen were consistently negative. Nineteen of the 21 cases showed immunoreactivity for CD34. Ductal epithelial cells were positive for both the oestrogen receptor and the progesterone receptor, whereas stromal cells were negative. CONCLUSIONS: Pseudoangiomatous hyperplasia of mammary stroma was present in approximately one quarter of the cases of gynaecomastia. This immunohistochemical study confirms the mesenchymal origin of the stromal cells that line the pseudovascular spaces, as has been found in female cases of pseudoangiomatous hyperplasia of mammary stroma.<\/jats:p>","DOI":"10.1136\/jcp.51.3.204","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"204-206","source":"Crossref","is-referenced-by-count":70,"title":["Pseudoangiomatous hyperplasia of mammary stroma associated with gynaecomastia."],"prefix":"10.1136","volume":"51","author":[{"given":"M F","family":"Milanezi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F P","family":"Saggioro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Zanati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bazan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F C","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2559.1995.tb00255.x","article-title":"Pseudoangiomatous hyperplasia of male breast","volume":"26","author":"Badve, S.; Sloane, J.P.","year":"1995","unstructured":"Badve S, Sloane JP. Pseudoangiomatous hyperplasia of male breast. Histopathology 1995;26:463\u20136.","journal-title":"Histopathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/1097-0142(19890315)63:6<1154::AID-CNCR2820630619>3.0.CO;2-Q","article-title":"Pseudoangiomatous hyperplasia of mammary stroma\u2014some observations regarding its clinicopathologic spectrum","volume":"63","author":"Ibrahim, R.E.; Sciotto, C.G.; Weidner, N.","year":"1989","unstructured":"Ibrahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma\u2014some observations regarding its clinicopathologic spectrum. Cancer 1989;63: 1154\u201360.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00000478-199503000-00004","article-title":"Pseudoangiomatous stromal hyperplasia. 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MIB-1 is a suitable marker of proliferative activity in formalin-fixed, paraYn-embedded sections of breast cancer. Int J Surg Pathol 1995;2:287\u201394.","journal-title":"Int J Surg Pathol"},{"key":"ref_7","first-page":"103","article-title":"Its incidence, recognition and host characteristics in 447 autopsy cases","volume":"34","author":"Gynecomastia, Williams M.J.","year":"1963","unstructured":"Williams MJ. Gynecomastia. Its incidence, recognition and host characteristics in 447 autopsy cases. Ann J Med 1963; 34:103\u201312.","journal-title":"Ann J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1210\/jcem-32-2-173","article-title":"A study of the histopathology of human gynecomastia","volume":"32","author":"Nicolis, G.L.; Modlinger, R.S.; Gabrilove, J.L.","year":"1971","unstructured":"Nicolis GL, Modlinger RS, Gabrilove JL. A study of the histopathology of human gynecomastia. 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