{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:18:28Z","timestamp":1782523108438,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p>This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.<\/jats:p>","DOI":"10.1136\/jcp.51.4.324","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"324-325","source":"Crossref","is-referenced-by-count":40,"title":["Apolipoprotein E alleles in women with severe pre-eclampsia."],"prefix":"10.1136","volume":"51","author":[{"given":"B","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"J","family":"Rig\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fintor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kar\u00e1di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"ref_1","article-title":"American College of Obstericians and Gynecologists: Technical Bulletin No. 91. Management of Preeclampsia","year":"1986","unstructured":"American College of Obstericians and Gynecologists: Technical Bulletin No. 91. Management of Preeclampsia. February 1986."},{"issue":"3","key":"ref_2","first-page":"373","article-title":"Genotyping and sequence analysis of apolipoprotein E isoforms","volume":"1988","author":"Emi, M.; Wu, L.L.; Robertson, M.A.","unstructured":"Emi M, Wu LL, Robertson MA, et al. Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics 1988;3:373\u20139.","journal-title":"Genomics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/jcp.48.4.295","article-title":"Rapid and sensitive determination of human apolipoprotein E genotypes by miniaturized SDS-PAGE in non-insulin dependent diabetes mellitus","volume":"48","author":"Clavel, C.; Durlach, A.; Durlach, V.","year":"1995","unstructured":"Clavel C, Durlach A, Durlach V, et al. Rapid and sensitive determination of human apolipoprotein E genotypes by miniaturized SDS-PAGE in non-insulin dependent diabetes mellitus. J Clin Pathol 1995;48:295\u20139.","journal-title":"J Clin Pathol"},{"key":"ref_4","first-page":"598","article-title":"Determination of PCR-RFLP of apoE genotype in Japanese population","volume":"121","author":"Tsukamoto, K.; Watanabe, T.; Matsushima, T.","year":"1993","unstructured":"Tsukamoto K, Watanabe T, Matsushima T, et al. Determination of PCR-RFLP of apoE genotype in Japanese population. J Lab Clin Med 1993;121:598\u2013602.","journal-title":"J Lab Clin Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1399-0004.1996.tb02345.x","article-title":"High levels of Lp(a) lipoprotein in a family with cases of severe pre-eclampsia","volume":"50","author":"Husby, H.; Roald, B.; Schjetlein, R.","year":"1996","unstructured":"Husby H, Roald B, Schjetlein R, et al. High levels of Lp(a) lipoprotein in a family with cases of severe pre-eclampsia. Clin Genet 1996;50:47\u20139.","journal-title":"Clin Genet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-2275(20)40753-9","article-title":"Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein","volume":"34","author":"Kinoshita, M.; Arai, H.; Fukasawa, M.","year":"1993","unstructured":"Kinoshita M, Arai H, Fukasawa M, et al. Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein. J Lipid Res 1993;34:261\u2013 8.","journal-title":"J Lipid Res"},{"key":"ref_7","first-page":"447","article-title":"Apolipoprotein E (apoE) phenotypes and risk of preeclampsia","volume":"174","author":"Williams, A.M.; Zingheim, R.W.; King, I.B.","year":"1996","unstructured":"Williams AM, Zingheim RW, King IB, et al. Apolipoprotein E (apoE) phenotypes and risk of preeclampsia. Am J Obstet Gynec 1996;174:447.","journal-title":"Am J Obstet Gynec"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0029-7844(96)00514-5","article-title":"Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis","volume":"89","author":"Sattar, N.; Bendomir, A.; Berry, C.","year":"1997","unstructured":"Sattar N, Bendomir A, Berry C, et al. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 1997;89:403\u20138.","journal-title":"Obstet Gynecol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.51.4.324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:10:39Z","timestamp":1765595439000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.51.4.324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1998,4,1]]},"published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1136\/jcp.51.4.324"],"URL":"https:\/\/doi.org\/10.1136\/jcp.51.4.324","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}