{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:54:09Z","timestamp":1764996849995,"version":"3.45.0"},"reference-count":16,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>AIMS: To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. METHODS: Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). RESULTS: Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. CONCLUSIONS: Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.<\/jats:p>","DOI":"10.1136\/jcp.51.5.396","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"396-398","source":"Crossref","is-referenced-by-count":27,"title":["Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)."],"prefix":"10.1136","volume":"51","author":[{"given":"K","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2559.1987.tb02654.x","article-title":"Malignant lymphoma of mucosaassociated lymphoid tissue","volume":"11","author":"Isaacson, P.G.; Spencer, J.","year":"1987","unstructured":"Isaacson PG, Spencer J. Malignant lymphoma of mucosaassociated lymphoid tissue. Histopathology 1987;11:445\u2013 62.","journal-title":"Histopathology"},{"key":"ref_2","first-page":"1190","article-title":"Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion","volume":"10","author":"Du, M.; Diss, T.C.; Xu, C.","year":"1996","unstructured":"Du M, Diss TC, Xu C, et al. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 1996;10:1190\u20137.","journal-title":"Leukemia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-5699(92)90199-H","article-title":"Germinal centers in T cell dependent antibody responses","volume":"13","author":"Liu, Y.J.; Johnson, G.D.; Gordon, J.","year":"1992","unstructured":"Liu YJ, Johnson GD, Gordon J, et al. Germinal centers in T cell dependent antibody responses. Immunol Today 1992; 13:17\u201321.","journal-title":"Immunol Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0046-8177(93)90235-9","article-title":"Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy","volume":"24","author":"Genta, R.M.; Hamner, H.W.; Graham, D.Y.","year":"1993","unstructured":"Genta RM, Hamner HW, Graham DY. Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum Pathol 1993;24:577\u201383.","journal-title":"Hum Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma","volume":"338","author":"Wotherspoon, A.C.; Ortiz\u2013Hidalgo, C.; Falzon, M.R.","year":"1991","unstructured":"Wotherspoon AC, Ortiz\u2013Hidalgo C, Falzon MR, et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175\u20136.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(95)90113-2","article-title":"Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection","volume":"345","author":"Bayerd\u00f6rVer, E.; Neubauer, A.; Rudorph, B.","year":"1995","unstructured":"Bayerd\u00f6rVer E, Neubauer A, Rudorph B, et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. Lancet 1995;345:1591\u20134.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0140-6736(93)91409-F","article-title":"Regression of primary low grade B-cell gastric lymphoma of mucosaassociated lymphoid tissue type after eradication of Helicobacter pylori","volume":"342","author":"Wotherspoon, A.C.; Doglioni, C.; Diss, T.C.","year":"1993","unstructured":"Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low grade B-cell gastric lymphoma of mucosaassociated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342:575\u20137.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(94)90208-9","article-title":"Relapse of MALT lymphoma associated with Helicobacter pylori after antibiotic treatment","volume":"343","author":"Horstmann, M.; Erttmann, R.; Winkler, K.","year":"1994","unstructured":"Horstmann M, Erttmann R, Winkler K. Relapse of MALT lymphoma associated with Helicobacter pylori after antibiotic treatment. Lancet 1994;343:1098\u20139.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0140-6736(95)90195-7","article-title":"Helicobacter pylori reinfection and rapid relapse of low-grade B-cell gastric lymphoma","volume":"345","author":"Cammarota, G.; Montalto, M.; Tursi, A.","year":"1995","unstructured":"Cammarota G, Montalto M, Tursi A, et al. Helicobacter pylori reinfection and rapid relapse of low-grade B-cell gastric lymphoma. Lancet 1995;345:192","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0046-8177(96)90071-4","article-title":"Detection of immunoglobulin heavy chain gene rearrangement by polymerase chain reaction in chronic active gastritis associated with Helicobacter pylori","volume":"27","author":"Hsi, E.D.; Greenson, J.K.; Singleton, T.P.","year":"1996","unstructured":"Hsi ED, Greenson JK, Singleton TP, et al. Detection of immunoglobulin heavy chain gene rearrangement by polymerase chain reaction in chronic active gastritis associated with Helicobacter pylori. Hum Pathol 1996;27:290\u20136.","journal-title":"Hum Pathol"},{"key":"ref_11","first-page":"572","article-title":"Idiotype identity in a MALT-type lymphoma and B cell in Helicobacter pylori associated chronic gastritis","volume":"70","author":"Greiner, A.; Marx, A.; Heesemann, J.","year":"1994","unstructured":"Greiner A, Marx A, Heesemann J, et al. Idiotype identity in a MALT-type lymphoma and B cell in Helicobacter pylori associated chronic gastritis. Lab Invest 1994;70:572\u20138.","journal-title":"Lab Invest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2958.1993.tb01724.x","article-title":"The HSP60 protein of Helicobacter pylori: structure and immune response in patient with gastroduodenal diseases","volume":"9","author":"Macchia, G.; Massone, A.; Burroni, D.","year":"1993","unstructured":"Macchia G, Massone A, Burroni D, et al. The HSP60 protein of Helicobacter pylori: structure and immune response in patient with gastroduodenal diseases. Mol Microbiol 1993;9:645\u201352.","journal-title":"Mol Microbiol"},{"key":"ref_13","first-page":"976","article-title":"An increased number of g\/d T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pyloriassociated chronic gastritis of the antrum","volume":"86","author":"Engstrand, L.; Scheynius, A.; Pahlson, C.","year":"1991","unstructured":"Engstrand L, Scheynius A, Pahlson C. An increased number of g\/d T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pyloriassociated chronic gastritis of the antrum. Am J Gastroenterol 1991;86:976\u201380.","journal-title":"Am J Gastroenterol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0016-5085(91)90023-E","article-title":"Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa","volume":"101","author":"Negrini, R.; Lisato, L.; Zanella, I.","year":"1991","unstructured":"Negrini R, Lisato L, Zanella I, et al. Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa. Gastroenterology 1991;101:437\u201345.","journal-title":"Gastroenterology"},{"key":"ref_15","first-page":"285","article-title":"Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type","volume":"142","author":"Hussell, T.; Isaacson, P.G.; Crabtree, J.E.","year":"1993","unstructured":"Hussell T, Isaacson PG, Crabtree JE, et al. Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Am J Pathol 1993;142:285\u201392.","journal-title":"Am J Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1053\/gast.1996.v111.pm8780570","article-title":"Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis","volume":"111","author":"Neglini, R.; Savio, A.; Poiesi, C.","year":"1996","unstructured":"Neglini R, Savio A, Poiesi C, et al. Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 1996;111:655\u201365.","journal-title":"Gastroenterology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.51.5.396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:12:00Z","timestamp":1763748720000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.51.5.396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,5,1]]},"published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1136\/jcp.51.5.396"],"URL":"https:\/\/doi.org\/10.1136\/jcp.51.5.396","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}