{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:15:45Z","timestamp":1765728945840,"version":"3.48.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>A solitary small intestinal ulcer associated with a carcinoid tumour in a nearby Meckel's diverticulum was found in a 77 year old man presenting with massive rectal bleeding. Angiography and a radioisotope study localised the bleeding to the ileum. At operation, the Meckel's diverticulum was identified, with bleeding from an ulcer just distal to it. Pathological examination revealed a small carcinoid tumour confined to the Meckel's diverticulum. Close to the opening of the diverticulum, within the ileum, a well demarcated ulcer was present. Histology showed a non-specific ulcer which eroded a large blood vessel. This is the first documented occurrence of solitary small intestinal ulceration in association with a carcinoid tumour. Carcinoid tumour should be added to the list of possible causes of small intestinal ulceration. The ulceration may be secondary to release of cytokines by the tumour.<\/jats:p>","DOI":"10.1136\/jcp.52.1.72","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"72-74","source":"Crossref","is-referenced-by-count":4,"title":["Small intestinal ulceration secondary to carcinoid tumour arising in a Meckel's diverticulum."],"prefix":"10.1136","volume":"52","author":[{"given":"W G","family":"McCluggage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"McConnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S T","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/jcp.23.2.110","article-title":"Elastic vascular sclerosis of mesenteric blood vessels in argentaYn carcinoma","volume":"23","author":"Anthony, P.P.; Drury, R.B.A.","year":"1970","unstructured":"Anthony PP, Drury RBA. Elastic vascular sclerosis of mesenteric blood vessels in argentaYn carcinoma. J Clin Pathol 1970;23:110\u201318.","journal-title":"J Clin Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF02586617","article-title":"Carcinoid tumors, vascular elastosis and ischaemic disease of the small intestine","volume":"20","author":"Qizilbash, A.H.","year":"1977","unstructured":"Qizilbash AH. Carcinoid tumors, vascular elastosis and ischaemic disease of the small intestine. Dis Colon Rectum 1977;20:554\u201360.","journal-title":"Dis Colon Rectum"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/gut.30.5.691","article-title":"Intestinal infarction caused by carcinoid associated elastic vascular sclerosis: early presentation of a small ileal carcinoid tumour","volume":"30","author":"Harvey, J.N.; Deuyer, M.E.; Da Costa, P.","year":"1989","unstructured":"Harvey JN, Deuyer ME, Da Costa P. Intestinal infarction caused by carcinoid associated elastic vascular sclerosis: early presentation of a small ileal carcinoid tumour. Gut 1989;30:691\u20134.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1440-1746.1994.tb01730.x","article-title":"Intestinal ischaemia associated with carcinoid tumour: a case report with review of the pathogenesis","volume":"9","author":"Bessell, JR, Karatassas; A, Allen; P.W.","year":"1994","unstructured":"Bessell JR, Karatassas A, Allen PW. Intestinal ischaemia associated with carcinoid tumour: a case report with review of the pathogenesis. J Gastroenterol Hepatol 1994;9:304\u20137. McCluggage, McConnell, Sloan, et al","journal-title":"J Gastroenterol Hepatol"},{"key":"ref_5","first-page":"499","article-title":"carcinoid tumors and intestinal ischemia","volume":"41","author":"Strobbe, L.","year":"1994","unstructured":"Strobbe L, D\u2019Hondt ED, Ramboer C, et al. 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Immunohistochemical expression of transforming growth factor alpha and epidermal growth factor receptor in gastrointestinal carcinoids. Am J Surg Pathol 1997;21:327\u201333.","journal-title":"Am J Surg Pathol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01008032","article-title":"Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaYn cells and related gastrointestinal tumours","volume":"430","author":"LaRosa, S.; Chiaravalli, A.M.; Capella, C.","year":"1997","unstructured":"LaRosa S, Chiaravalli AM, Capella C, et al. Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaYn cells and related gastrointestinal tumours. Virchows Arch 1997;430:117\u201324.","journal-title":"Virchows Arch"},{"key":"ref_13","article-title":"Neoplasms of Meckel\u2019s diverticulum. 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Journal of Clinical Pathology http:\/\/www.jclinpath.com","journal-title":"Journal of Clinical Pathology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.52.1.72","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:10:36Z","timestamp":1765728636000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.52.1.72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]},"published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1136\/jcp.52.1.72"],"URL":"https:\/\/doi.org\/10.1136\/jcp.52.1.72","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}