{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:06:27Z","timestamp":1782255987918,"version":"3.54.5"},"reference-count":18,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>AIM: To determine whether the pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence or absence of duodenal pathology. METHODS: 50 cases (M:F, 26:24; median age 57 years) diagnosed as lymphocytic gastritis between 1986 and 1998 with concurrent duodenal (D2) biopsies were identified from a computer search of the pathology records and validated by counting gastric intraepithelial lymphocytes. Gastric and duodenal intraepithelial lymphocyte counts were performed on haematoxylin and eosin (H&amp;E) and anti-CD3 stained sections. D2 biopsies were assessed for villous atrophy and chronic inflammatory cell infiltration by subjective grading, and gastritis was classified and graded according to the updated Sydney system. A case was designated corpus predominant when the corpus chronic inflammation grade exceeded that of the antrum. If it was less, then the case was antrum predominant, and if they were equal it was diffuse (pan-) gastritis. The ratio between the corpus and antral intraepithelial lymphocyte count in individual patients was calculated. RESULTS: Of 50 cases of lymphocytic gastritis, 21 were classified as corpus predominant. With one exception (a case of mild villous atrophy), all were accompanied by normal duodenal morphology. Cases with a corpus predominant gastritis had median duodenal intraepithelial lymphocyte counts of 19 (H&amp;E) and 14.1 (CD3), whereas 29 subjects with an antrum predominant or diffuse gastritis had median counts of 39.9 (H&amp;E) and 37.9 (CD3). Fifteen of these 29 cases (52%) showed villous atrophy; all were graded as moderate or severe. Patients with any degree of villous atrophy had a mean corpus\/antrum intraepithelial lymphocyte ratio (H&amp;E) of 0.59 (representing antral predominance), while those with normal duodenal morphology had a ratio of 2.39 (p &lt; 0.0001). CONCLUSIONS: The pattern of involvement of gastric mucosa in lymphocytic gastritis is closely related to the associated duodenal pathology. Those with the corpus predominant form are unlikely to have duodenal pathology, while those with an antral predominant or diffuse form should have distal duodenal biopsies taken to exclude villous atrophy.<\/jats:p>","DOI":"10.1136\/jcp.52.11.815","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"815-819","source":"Crossref","is-referenced-by-count":36,"title":["The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology."],"prefix":"10.1136","volume":"52","author":[{"given":"M","family":"Hayat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"O'Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/gut.29.9.1258","article-title":"Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study","volume":"29","author":"Haot, J.; Hamichi, L.; Wallez, L.","year":"1988","unstructured":"Haot J, Hamichi L, Wallez L, et al. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study. Gut 1988;29:1258\u201364.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1136\/gut.31.3.282","article-title":"Lymphocytic gastritis\u2014 prospective study of its relationship with varioliform gastritis","volume":"31","author":"Haot, J.; Jouret, A.; Willette, M.","year":"1990","unstructured":"Haot J, Jouret A, Willette M, et al. Lymphocytic gastritis\u2014 prospective study of its relationship with varioliform gastritis. Gut 1990;31:282\u20135.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/BF01297450","article-title":"Lymphocytic gastritis in nonulcer dyspepsia","volume":"36","author":"Jaskiewicz, K.; Price, S.K.; Zak, J.","year":"1991","unstructured":"Jaskiewicz K, Price SK, Zak J, et al. Lymphocytic gastritis in nonulcer dyspepsia. Dig Dis Sci 1991;36:1079\u201383.","journal-title":"Dig Dis Sci"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.1711540204","article-title":"Lymphocytic gastritis: relationship to Campylobacter pylori infection","volume":"154","author":"Dixon, M.F.; Wyatt, J.I.; Burke, D.A.","year":"1988","unstructured":"Dixon MF, Wyatt JI, Burke DA, et al. Lymphocytic gastritis: relationship to Campylobacter pylori infection. J Pathol 1988;154:125\u201332.","journal-title":"J Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/jcp.48.12.1111","article-title":"Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis","volume":"48","author":"Niemela, S.; Karttunen, T.; Kerola, T.","year":"1995","unstructured":"Niemela S, Karttunen T, Kerola T, et al. Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. J Clin Pathol 1995;48:1111\u201316.","journal-title":"J Clin Pathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/00000478-199607000-00010","article-title":"Gastric and oesophageal intraepithelial lymphocytes in pediatric celiac disease","volume":"20","author":"Alsaigh, N.; Odze, R.; Goldman, H.","year":"1996","unstructured":"Alsaigh N, Odze R, Goldman H, et al. Gastric and oesophageal intraepithelial lymphocytes in pediatric celiac disease. Am J Surg Pathol 1996;20:865\u201370.","journal-title":"Am J Surg Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-3476(94)70254-3","article-title":"Lymphocytic gastritis: a positive relationship with celiac disease","volume":"124","author":"C, De Giacomo; A, Gianatti; R, Negrini","year":"1994","unstructured":"De Giacomo C, Gianatti A, Negrini R, et al. Lymphocytic gastritis: a positive relationship with celiac disease. J Pediatr 1994;124:57\u201362.","journal-title":"J Pediatr"},{"key":"ref_8","first-page":"1161","article-title":"Classification and grading of gastritis. The updated Sydney system","volume":"20","author":"Dixon, M.F.; Genta, R.M.; Yardley, J.H.","year":"1994","unstructured":"Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161\u201381.","journal-title":"International Workshop on the Histopathology of Gastritis, Houston; Am J Surg Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/jcp.45.9.784","article-title":"Collagenous colitis: Jejunal and colorectal pathology","volume":"45","author":"Armes, J.; Gee, D.C.; MaCrae, F.A.","year":"1992","unstructured":"Armes J, Gee DC, MaCrae FA, et al. Collagenous colitis: Jejunal and colorectal pathology. J Clin Pathol 1992;45: 784\u20137.","journal-title":"J Clin Pathol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/jcp.50.6.527","article-title":"Small intestine in lymphocytic and collagenous colitis: mucosal morphology, permeability, and secretory immunity to gliadin","volume":"50","author":"Moayyedi, P.; O\u2019Mahony, S.; Jackson, P.","year":"1997","unstructured":"Moayyedi P, O\u2019Mahony S, Jackson P, et al. Small intestine in lymphocytic and collagenous colitis: mucosal morphology, permeability, and secretory immunity to gliadin. J Clin Pathol 1997;50:527\u20139.","journal-title":"J Clin Pathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0016-5085(90)90819-M","article-title":"Lymphocytic gastritis in patients with celiac sprue or spruelike intestinal disease","volume":"98","author":"Wolber, R.; Owen, D.; DelBuono, L.","year":"1990","unstructured":"Wolber R, Owen D, DelBuono L, et al. Lymphocytic gastritis in patients with celiac sprue or spruelike intestinal disease. Gastroenterology 1990;98:310\u201315.","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/jcp.51.3.207","article-title":"Lymphocytic gastritis and coeliac disease: evidence of a positive association","volume":"51","author":"Feeley, K.M.; Heneghan, M.A.; Stevens, F.M.","year":"1998","unstructured":"Feeley KM, Heneghan MA, Stevens FM, et al. Lymphocytic gastritis and coeliac disease: evidence of a positive association. J Clin Pathol 1998;51:207\u201310.","journal-title":"J Clin Pathol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1001\/jama.1989.03430070083035","article-title":"Lymphocytic enterocolitis in patients with \u201crefractory sprue,\u201d","volume":"262","author":"Dubois, R.N.; Lazenby, A.J.; Yardley, J.H.","year":"1989","unstructured":"Dubois RN, Lazenby AJ, Yardley JH, et al. Lymphocytic enterocolitis in patients with \u201crefractory sprue,\u201d JAMA 1989;262:935\u20137.","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/0140-6736(90)91183-B","article-title":"Rectal gluten challenge and diagnosis of coeliac disease","volume":"335","author":"Loft, D.E.; Marsh, M.N.; Crowe, P.","year":"1990","unstructured":"Loft DE, Marsh MN, Crowe P. Rectal gluten challenge and diagnosis of coeliac disease. Lancet 1990;335:1293\u20135.","journal-title":"Lancet"},{"issue":"1","key":"ref_15","first-page":"319","article-title":"The eVects of H pylori eradication on the natural history of lymphocytic gastritis","volume":"42","author":"Hayat, M.; Arora, D.S.; Dixon, M.F.","year":"1998","unstructured":"Hayat M, Arora DS, Dixon MF, et al. The eVects of H pylori eradication on the natural history of lymphocytic gastritis. Gut 1998;42(suppl 1):319.","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/jcp.48.10.939","article-title":"Lymphocytic gastritis and associated small bowel disease: a diVuse lymphocytic gastroenteropathy?","volume":"48","author":"Lynch, D.A.F.; Sobala, G.M.; Dixon, M.F.","year":"1995","unstructured":"Lynch DAF, Sobala GM, Dixon MF, et al. Lymphocytic gastritis and associated small bowel disease: a diVuse lymphocytic gastroenteropathy? J Clin Pathol 1995;48:939\u201345.","journal-title":"J Clin Pathol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/gut.34.2.150","article-title":"Clinical and pathological spectrum of coeliac disease-active, silent, latent, potential","volume":"34","author":"Ferguson, A.; Arranz, E.; O\u2019Mahony, S.","year":"1993","unstructured":"Ferguson A, Arranz E, O\u2019Mahony S. Clinical and pathological spectrum of coeliac disease-active, silent, latent, potential. Gut 1993;34:150\u20131.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00000478-199804000-00010","article-title":"High proportion of Granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis","volume":"22","author":"Oberhuber, G.; Bodingbauer, M.; Mosberger, I.","year":"1998","unstructured":"Oberhuber G, Bodingbauer M, Mosberger I, et al. High proportion of Granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. 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