{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:23:32Z","timestamp":1787808212260,"version":"build-2784847793"},"reference-count":5,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>Full clinicopathological details and clinical follow up of a case of malignant transformation within a tailgut cyst are presented. A 43 year old woman presented with signs and symptoms of an imminent threatened abortion. Routine examination identified a coincidental, asymptomatic retrorectal\/presacral mass. Following imaging studies, surgical resection was carried out and an adenocarcinoma arising within a pre-existent tailgut cyst was identified by microscopy. Four years later the patient presented with neurological symptoms consistent with local recurrence of the tumour. Surgical biopsies confirmed this diagnosis and she was subsequently started on chemotherapy. She died soon after from a cause unrelated to the disease, after declining further active intervention. Differential diagnosis of such cases includes (cystic) teratoma, epidermal cyst, rectal duplication cyst, anal gland cyst and carcinoma, extension of local carcinoma, and metastatic disease. It is recommended that these lesions be completely excised when detected incidentally.<\/jats:p>","DOI":"10.1136\/jcp.52.4.310","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"310-312","source":"Crossref","is-referenced-by-count":39,"title":["Adenocarcinoma arising within a tailgut cyst: clinicopathological description and follow up of an unusual case."],"prefix":"10.1136","volume":"52","author":[{"given":"J F","family":"Graadt van Roggen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Welvaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"de Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G J","family":"Offerhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Hogendoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"ref_1","first-page":"707","article-title":"Retrorectal cysthamartomas. Report of two cases with adenocarcinoma developing in one","volume":"6","author":"Marco, V.; Autonell, J.; Farre, J.","year":"1982","unstructured":"Marco V, Autonell J, Farre J, et al. Retrorectal cysthamartomas. Report of two cases with adenocarcinoma developing in one. Am J Surg Pathol 1982;6:707\u201314.","journal-title":"Am J Surg Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ajcp\/89.2.139","article-title":"Tailgut cysts. Report of 53 cases","volume":"89","author":"Hjermstad, B.M.; Helwig, E.B.","year":"1988","unstructured":"Hjermstad BM, Helwig EB. Tailgut cysts. Report of 53 cases. Am J Clin Pathol 1988;89:139\u201347.","journal-title":"Am J Clin Pathol"},{"key":"ref_3","first-page":"1","article-title":"Sacrococcygeal tumours. Adenocarcinoma of a cystic congenital embryonal remnant","volume":"14","author":"Ballantine, E.N.","year":"1931","unstructured":"Ballantine EN. Sacrococcygeal tumours. Adenocarcinoma of a cystic congenital embryonal remnant. Arch Pathol 1931;14:1\u20139.","journal-title":"Arch Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF02587141","article-title":"Presacral tumours and cysts in adults","volume":"18","author":"Uhlig, B.E.; Johnson, R.L.","year":"1975","unstructured":"Uhlig BE, Johnson RL. Presacral tumours and cysts in adults. Dis Colon Rectum 1975;18:581\u201396.","journal-title":"Dis Colon Rectum"},{"key":"ref_5","article-title":"Ackerman\u2019s surgical pathology","author":"Rosai, J.","year":"1995","unstructured":"Rosai J, ed. Ackerman\u2019s surgical pathology, 8th ed. New York: CV Mosby, 1995.","edition":"8th ed"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.52.4.310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:50:23Z","timestamp":1765011023000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.52.4.310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,4,1]]},"published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1136\/jcp.52.4.310"],"URL":"https:\/\/doi.org\/10.1136\/jcp.52.4.310","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}