{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:11:40Z","timestamp":1765887100637,"version":"3.44.0"},"reference-count":34,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>AIM: To determine if there is a correlation between the histological findings in the gastric mucosa and the degree of cell proliferation in gastric antral biopsies. METHODS: Cell proliferation in gastric antral biopsies was determined by in vitro bromodeoxyuridine labelling. Histological sections were assessed using the Sydney System. RESULTS: There was a positive correlation between antral mucosal cell proliferation and the acute inflammatory cell infiltrate (r = 0.29; p = 0.03). There was a stronger correlation with the chronic inflammatory cell infiltrate (r = 0.53; p &lt; 0.0001) and the density of H pylori colonisation (r = 0.54; p &lt; 0.0001). There was no correlation between gastric epithelial proliferation and the degree of atrophy. Stepwise multiple regression indicates that the only independent predictor of epithelial cell proliferation is the density of H pylori colonisation (p &lt; 0.0001). CONCLUSIONS: H pylori increases gastric epithelial cell proliferation through the mucosal inflammatory response and probably by other means. The strong correlation between epithelial proliferation, the chronic inflammatory cell infiltrate, and the density of H pylori colonization may have implications for gastric carcinogenesis.<\/jats:p>","DOI":"10.1136\/jcp.52.5.367","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"367-371","source":"Crossref","is-referenced-by-count":20,"title":["Correlation between epithelial cell proliferation and histological grading in gastric mucosa."],"prefix":"10.1136","volume":"52","author":[{"given":"D A","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"Mapstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Moayyedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Quirke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A T","family":"Axon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/gut.36.3.346","article-title":"Cell proliferation in Helicobacter pylori associated gastritis and the eVect of eradication therapy","volume":"36","author":"Lynch, D.A.F.; Mapstone, N.P.; Clarke, A.M.T.","year":"1995","unstructured":"Lynch DAF, Mapstone NP, Clarke AMT, et al. Cell proliferation in Helicobacter pylori associated gastritis and the eVect of eradication therapy. Gut 1995;36:346\u201350.","journal-title":"Gut"},{"key":"ref_2","first-page":"351","article-title":"Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection","volume-title":"Gut","volume":"36","author":"Lynch, D.A.F.; Mapstone, N.P.; Clarke, A.M.T.","year":"1995","unstructured":"Lynch DAF, Mapstone NP, Clarke AMT, et al. Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection. Gut 1995;36: 351\u20133."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1746.1991.tb01468.x","article-title":"The Sydney system: histological division","volume":"6","author":"Price, A.B.","year":"1991","unstructured":"Price AB. The Sydney system: histological division. J Gastroenterol Hepatol 1991;6:209\u201322.","journal-title":"J Gastroenterol Hepatol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/gut.34.8.1032","article-title":"EVect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men","volume":"34","author":"Katelaris, P.H.; Seow, F.; Lin, B.P.C.","year":"1993","unstructured":"Katelaris PH, Seow F, Lin BPC, et al. DB. EVect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut 1993;34:1032\u20137.","journal-title":"Gut"},{"key":"ref_5","first-page":"164","article-title":"Systemic mediators of inflammation","volume":"45","author":"Emery, P.; Salmon, M.","year":"1991","unstructured":"Emery P, Salmon M. Systemic mediators of inflammation. Br J Hosp Med 1991;45:164\u20138.","journal-title":"Br J Hosp Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/cs0820581","article-title":"Growth regulatory peptides in gastric mucosa","volume":"82","author":"Jankowski, J.; Al-Rawi, H.J.; Johnston, D.A.","year":"1992","unstructured":"Jankowski J, Al-Rawi HJ, Johnston DA, et al. Growth regulatory peptides in gastric mucosa. Clin Sci 1992;82:581\u20137.","journal-title":"Clin Sci"},{"key":"ref_7","first-page":"3","article-title":"Epidemiology of stomach cancer","volume":"11","author":"Hirayama, T.","year":"1971","unstructured":"Hirayama T. Epidemiology of stomach cancer. Gann Monogr Cancer Res 1971;11:3\u201319.","journal-title":"Gann Monogr Cancer Res"},{"key":"ref_8","first-page":"969","article-title":"Stomach cancer among Japanese in Hawaii","volume":"49","author":"Haenszel, W.; Kurihara, M.; Segi, M.","year":"1972","unstructured":"Haenszel W, Kurihara M, Segi M, et al. Stomach cancer among Japanese in Hawaii. J Natl Cancer Inst 1972;49:969\u2013 88.","journal-title":"J Natl Cancer Inst"},{"key":"ref_9","first-page":"887","article-title":"Hypothesis: the role of the lung in carcinogenesis","volume":"121","author":"Meyer, M.B.; Luk, G.D.; Sotelo, J.M.","year":"1980","unstructured":"Meyer MB, Luk GD, Sotelo JM, et al. Hypothesis: the role of the lung in carcinogenesis. Am Rev Respir Dis 1980;121: 887\u201392.","journal-title":"Am Rev Respir Dis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/oxfordjournals.aje.a113146","article-title":"Wine and tobacco: risk factors for gastric cancer in France","volume":"113","author":"Hoey, J.; Montwernay, C.; Laubert, R.","year":"1981","unstructured":"Hoey J, Montwernay C, Laubert R. Wine and tobacco: risk factors for gastric cancer in France. Am J Epidemiol 1981;113:668\u201374.","journal-title":"Am J Epidemiol"},{"issue":"4","key":"ref_11","series-title":"Gut","first-page":"119","article-title":"EVects of Helicobacter pylori infection on acid-catalysed N-nitrosation in gastric juice","volume":"34","author":"Sobala, G.M.","year":"1993","unstructured":"Sobala GM. EVects of Helicobacter pylori infection on acid-catalysed N-nitrosation in gastric juice [abstract]. Gut 1993;34(suppl)4:T119."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0016-5085(76)80309-5","article-title":"Cell proliferation kinetics in normal human gastric mucosa","volume":"70","author":"Hansen, O.H.; Pedersen, T.; Larsen, J.K.","year":"1976","unstructured":"Hansen OH, Pedersen T, Larsen JK. Cell proliferation kinetics in normal human gastric mucosa. Gastroenterology 1976;70:1051\u20134.","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0016-5085(97)70003-9","article-title":"Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis","volume":"113","author":"Wagner, S.; Beil, W.; Westermann, J.","year":"1997","unstructured":"Wagner S, Beil W, Westermann J, et al. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology 1997;113:1836\u2013 47.","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/gut.38.1.19","article-title":"Helicobacter pylori increases proliferation of gastric epithelial cells","volume":"38","author":"Fan, X.G.; Kelleher, D.; Fan, X.J.","year":"1996","unstructured":"Fan XG, Kelleher D, Fan XJ, et al. Helicobacter pylori increases proliferation of gastric epithelial cells. Gut 1996;38:19\u201322.","journal-title":"Gut"},{"key":"ref_15","first-page":"965","article-title":"Urea hydrolysis in patients with Campylobacter pyloridis infection","volume":"i:","author":"Langton, SR, Marshall; B.J.","year":"1986","unstructured":"Langton SR, Marshall BJ. Urea hydrolysis in patients with Campylobacter pyloridis infection. Lancet 1986;i:965\u20136.","journal-title":"Lancet"},{"key":"ref_16","first-page":"171","article-title":"Ammonia increases cell proliferation with progress of atrophic changes in rat gastric mucosa","volume":"100","author":"Tsujii, M.; Kawano, S.; Ito, T.","year":"1991","unstructured":"Tsujii M, Kawano S, Ito T, et al. Ammonia increases cell proliferation with progress of atrophic changes in rat gastric mucosa [abstract]. Gastroenterology 1991;100:A171.","journal-title":"Gastroenterology"},{"key":"ref_17","first-page":"5608","article-title":"A flow cytometric analysis of the eVect of sodium chloride on gastric cancer risk in the rat","volume":"45","author":"Charnley, G.; Tannenbaum, SR","year":"1985","unstructured":"Charnley G, Tannenbaum SR. A flow cytometric analysis of the eVect of sodium chloride on gastric cancer risk in the rat. Cancer Res 1985;45:5608\u201316.","journal-title":"Cancer Res"},{"key":"ref_18","first-page":"1424","article-title":"Gastric cell proliferation kinetics and bile reflux after partial gastrectomy","volume":"86","author":"Bechi, P.; Balzi, M.; Becciolini, A.","year":"1991","unstructured":"Bechi P, Balzi M, Becciolini A, et al. Gastric cell proliferation kinetics and bile reflux after partial gastrectomy. Am J Gastroenterol 1991;86:1424\u201332.","journal-title":"Am J Gastroenterol"},{"key":"ref_19","first-page":"54","article-title":"Influence of sodium intake on gastric antrum and corpus mucosal cell proliferation status","volume":"56","author":"E, De Koster; M, Buset; E, Fernandes","year":"1993","unstructured":"De Koster E, Buset M, Fernandes E, et al. Influence of sodium intake on gastric antrum and corpus mucosal cell proliferation status [abstract]. Acta Gastroenterol Belg 1993; 56(suppl):54.","journal-title":"Acta Gastroenterol Belg"},{"key":"ref_20","first-page":"124","article-title":"Helicobacter pylori and chronic gastritis","volume-title":"pylori and gastroduodenal disease","author":"Dixon, M.F.","year":"1992","unstructured":"Dixon MF. Helicobacter pylori and chronic gastritis. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylori and gastroduodenal disease, 2nd ed. Oxford: Blackwell Scientific Publications, 1992:124\u201339.","edition":"2nd ed"},{"key":"ref_21","first-page":"33","article-title":"Campylobacter pyloridis associated chronic antral gastritis. A prospective study of its prevalence and the eVects of antibacterial","volume-title":"and antiulcer treatment. Gastroenterology 1988; 94","author":"Rauws, E.J.; Langenberg, W.; HouthoV, H.J.","unstructured":"Rauws EJ, Langenberg W, HouthoV HJ, et al. Campylobacter pyloridis associated chronic antral gastritis. A prospective study of its prevalence and the eVects of antibacterial and antiulcer treatment. Gastroenterology 1988;94:33\u201340."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/000456329002700301","article-title":"Free radicals: their involvement in disease processes","volume":"27","author":"Lunec, J.","year":"1990","unstructured":"Lunec J. Free radicals: their involvement in disease processes. Ann Clin Biochem 1990;27:173\u201382.","journal-title":"Ann Clin Biochem"},{"key":"ref_23","first-page":"205","article-title":"Increased epidermal growth factors in gastric carcinomas","volume":"70","author":"PfeiVer, A.; Rothbauer, E.; Weibecke, B.","year":"1990","unstructured":"PfeiVer A, Rothbauer E, Weibecke B, et al. Increased epidermal growth factors in gastric carcinomas. Gastroenterology 1990;70:205\u201316.","journal-title":"Gastroenterology"},{"key":"ref_24","first-page":"209","article-title":"Mechanisms by which EGF receptor and TGF-alpha contribute to malignant transformation","volume":"9","author":"E, Di Marco; JH, Pierce; SA, Aaronson","year":"1990","unstructured":"Di Marco E, Pierce JH, Aaronson SA, et al. Mechanisms by which EGF receptor and TGF-alpha contribute to malignant transformation. Nat Immun Cell Growth Regul 1990;9:209\u201321.","journal-title":"Nat Immun Cell Growth Regul"},{"key":"ref_25","first-page":"453","article-title":"Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics","volume-title":"human gastric mucosa. Gastroenterology","volume":"73","author":"Hansen, O.H.; Johanssen, A.A.; Larsen, J.K.","year":"1977","unstructured":"Hansen OH, Johanssen AA, Larsen JK, et al. Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics in human gastric mucosa. Gastroenterology 1977;73:453\u20136."},{"key":"ref_26","first-page":"217","article-title":"Cell proliferation in normal and diseased gastric mucosa","volume":"87","author":"Hansen, O.H.; Johansen, A.A.; Larsen, J.K.","year":"1979","unstructured":"Hansen OH, Johansen AA, Larsen JK, et al. Cell proliferation in normal and diseased gastric mucosa. Acta Pathol Microbiol Scand 1979;87:217\u201322.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/gut.38.2.177","article-title":"Gastric epithelial cell kinetics in the progression from normal mucosa to gastric carcinoma","volume":"38","author":"Cahill, R.J.; Kilgallen, C.; Beattie, S.","year":"1996","unstructured":"Cahill RJ, Kilgallen C, Beattie S, et al. Gastric epithelial cell kinetics in the progression from normal mucosa to gastric carcinoma. Gut 1996;38:177\u201381.","journal-title":"Gut"},{"key":"ref_28","first-page":"1567","article-title":"Patterns of nucleic acid and protein synthesis in normal human gastric mucosa and atrophic gastritis","volume":"48","author":"Deschner, E.E.; Winawer, S.J.; Lipkin, M.","year":"1972","unstructured":"Deschner EE, Winawer SJ, Lipkin M. Patterns of nucleic acid and protein synthesis in normal human gastric mucosa and atrophic gastritis. J Natl Cancer Inst 1972;48:1567\u201374.","journal-title":"J Natl Cancer Inst"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1136\/gut.31.10.1097","article-title":"Variants of intestinal metaplasia in the evolution of chronic gastritis and gastric ulcer. A follow-up study","volume":"31","author":"Silva, S.; Filipe, M.I.; Pinho, A.","year":"1990","unstructured":"Silva S, Filipe MI, Pinho A. Variants of intestinal metaplasia in the evolution of chronic gastritis and gastric ulcer. A follow-up study. Gut 1990;31:1097\u2013104.","journal-title":"Gut"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2559.1979.tb02996.x","article-title":"A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study","volume":"3","author":"Jass, JR, Filipe; M.I.","year":"1979","unstructured":"Jass JR, Filipe MI. A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology 1979;3:191\u20139.","journal-title":"Histopathology"},{"key":"ref_31","first-page":"217","article-title":"Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa: its association with gastric carcinoma","volume":"88","author":"Sipponen, P.; Seppala, K.; Varis, K.","year":"1980","unstructured":"Sipponen P, Seppala K, Varis K, et al. Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa: its association with gastric carcinoma. Acta Pathol Microbiol Scand 1980;88:217\u201324.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_32","first-page":"1319","article-title":"Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres","volume-title":"Gut","volume":"26","author":"Filipe, M.I.; Potet, F.; Bogomoletz, W.V.","year":"1985","unstructured":"Filipe MI, Potet F, Bogomoletz WV, et al. Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut 1985;26:1319\u201326."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/030089168306900414","article-title":"Gastric epithelial dysplasia and sulphomucin-type intestinal metaplasia","volume":"69","author":"C, Arslan Pagnini; R, Farini; F, Cardin","year":"1983","unstructured":"Arslan Pagnini C, Farini R, Cardin F, et al. Gastric epithelial dysplasia and sulphomucin-type intestinal metaplasia. Tumori 1983;69:355\u20137.","journal-title":"Tumori"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.33.9.801","article-title":"Role of intestinal metaplasia in the histogenesis of gastric carcinoma","volume":"33","author":"Jass, JR","year":"1980","unstructured":"Jass JR. Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol 1980;33:801\u201310.","journal-title":"J Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.52.5.367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:02:33Z","timestamp":1758798153000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.52.5.367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,5,1]]},"published-print":{"date-parts":[[1999,5]]}},"alternative-id":["10.1136\/jcp.52.5.367"],"URL":"https:\/\/doi.org\/10.1136\/jcp.52.5.367","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}