{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:46Z","timestamp":1792098406077,"version":"4.4.0"},"reference-count":12,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>Two polypoid submucosal uterine lesions were examined histologically and immunohistochemically with monoclonal antibodies to desmin and alpha smooth muscle actin. One case comprised a leiomyoma and the other a polypoid form of adenomyosis. Both polyps had prolapsed through the external cervical os. The lesions had an ulcerated surface with focal areas of marked increased cellularity and pronounced vascularity throughout, such that they mimicked a low grade endometrial stromal sarcoma infiltrating the myometrium. The cellular areas showed diffuse positivity for desmin and alpha smooth muscle actin, confirming them to be of smooth muscle origin. The changes of marked hypercellularity and pronounced vascularity within polypoid submucosal uterine lesions have not been emphasised in published reports up to now. Pathologists should be aware of these morphological features in order to avoid misdiagnosis of such cases as endometrial stromal sarcomas. The changes described here are likely to be secondary to trauma associated with a polypoid lesion prolapsing through the external cervical os.<\/jats:p>","DOI":"10.1136\/jcp.52.7.543","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"543-546","source":"Crossref","is-referenced-by-count":19,"title":["Polypoid uterine lesions mimicking endometrial stromal sarcoma."],"prefix":"10.1136","volume":"52","author":[{"given":"W G","family":"McCluggage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Alderdice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Y","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-1-4757-1942-0_13","article-title":"Mesenchymal tumors of the uterus","volume-title":"Blaustein\u2019s pathology of the female genital tract","author":"Zaloudek, C.; Norris, H.J.","year":"1987","unstructured":"Zaloudek C, Norris HJ. Mesenchymal tumors of the uterus. In: Kurman RJ, ed. Blaustein\u2019s pathology of the female genital tract, 3rd ed. New York: Springer-Verlag, 1987:373\u2013408.","edition":"3rd ed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0002-9378(42)90417-4","article-title":"The etiologic and pathologic factors in a series of 1741 fibromyomas of the uterus","volume":"44","author":"Torpin, R.; Pund, E.; Peebles, W.J.","year":"1992","unstructured":"Torpin R, Pund E, Peebles WJ. The etiologic and pathologic factors in a series of 1741 fibromyomas of the uterus. Am J Obstet Gynecol 1992;44:569\u201374.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_3","first-page":"757","article-title":"Cellular benign mesenchymal tumors of the uterus","volume":"19","author":"Oliva, E.; Young, R.H.; Clement, P.B.","year":"1995","unstructured":"Oliva E, Young RH, Clement PB, et al. Cellular benign mesenchymal tumors of the uterus. Am J Surg Pathol 1995;19: 757\u201368.","journal-title":"Am J Surg Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/00000478-199109000-00006","article-title":"An imunohistochemical study of normal endometrial stroma and endometrial stromal neoplasms: evidence of smooth muscle diVerentiation","volume":"15","author":"Franquemont, D.W.; Frierson, H.F.; Mills, S.E.","year":"1991","unstructured":"Franquemont DW, Frierson HF, Mills SE. An imunohistochemical study of normal endometrial stroma and endometrial stromal neoplasms: evidence of smooth muscle diVerentiation. 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A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumors. Am J Surg Pathol 1995;19: 757\u201368.","journal-title":"Am J Surg Pathol"},{"key":"ref_9","first-page":"448","article-title":"Histologic findings in uterine leiomyomata of women treated with gonadotropinreleasing hormone agonists","volume":"97","author":"August, C.; Kepic, T.; Meier, L.","year":"1992","unstructured":"August C, Kepic T, Meier L, et al. Histologic findings in uterine leiomyomata of women treated with gonadotropinreleasing hormone agonists [abstract]. 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