{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:50:36Z","timestamp":1765075836431,"version":"3.46.0"},"reference-count":20,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014Type C gastritis caused by bile reflux has a characteristic appearance, similar to that seen in other forms of chemical gastritis, such as those associated with NSAIDs or alcohol. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. It has been shown previously that type C gastritis is associated with increased cell proliferation in the postsurgical stomach. The aim of this study was to determine cell proliferation in type C gastritis caused by bile reflux affecting the intact stomach.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Specimens from 15 patients with a histological diagnosis of type C gastritis on antral biopsy were obtained from the pathology archives between 1994 and 1997. A control group of nine normal antral biopsies was also selected and all underwent MIB-1 immunostaining. The gastric glands were divided into three zones (zone 1, gastric pit; zone 2, isthmus; and zone 3, gland base) and the numbers of positively staining nuclei for 500 epithelial cell nuclei were counted in each zone to determine the percentage labelling index (LI%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Cell proliferation was significantly higher in all three zones of the gastric glands with type C gastritis compared with controls as follows: zone 1, median LI% in type C gastritis 64.7 (range, 7.8\u201399.2), controls 4.7 (range, 2.0\u201311.3); zone 2, median LI% in type C gastritis 94.7 (range, 28.8\u201398.7), controls 40.2 (range, 23.1\u201370.3); and zone 3, median LI% in type C gastritis 20.0 (range, 1.3\u201396.0), controls 2.6 (range, 0.9\u20138.7).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Bile reflux is thought to act as a promoter of gastric carcinogenesis in the postsurgical stomach. The same may be true in the intact stomach.\n                  <\/jats:p>","DOI":"10.1136\/jcp.53.10.784","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"784-787","source":"Crossref","is-referenced-by-count":8,"title":["Cell proliferation in type C gastritis affecting the intact stomach"],"prefix":"10.1136","volume":"53","author":[{"given":"J E","family":"Mac Dowall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lamonby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A F","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,10,1]]},"reference":[{"key":"2025120618114230000_53.10.784.1","first-page":"6735","volume":"52","year":"1992","journal-title":"Cancer Res"},{"key":"2025120618114230000_53.10.784.2","unstructured":"Medline A, Farber E. The multistep theory of neoplasia. In: Anthony PP, Sweeney RNM, eds. Recent advances in histopathology, No. 11. Edinburgh: Churchill Livingstone 1981:19\u00e2\u0080\u009334."},{"key":"2025120618114230000_53.10.784.3","first-page":"S100","volume":"5","year":"1993","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025120618114230000_53.10.784.4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.351"},{"key":"2025120618114230000_53.10.784.5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2036.1994.tb00274.x","volume":"8","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"2025120618114230000_53.10.784.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1447"},{"key":"2025120618114230000_53.10.784.7","first-page":"1424","volume":"86","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"2025120618114230000_53.10.784.8","first-page":"S17","volume":"7","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025120618114230000_53.10.784.9","first-page":"594","volume":"176","year":"1993","journal-title":"Surgery Gynecol Obstet"},{"key":"2025120618114230000_53.10.784.10","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90059-0"},{"key":"2025120618114230000_53.10.784.11","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.5.524"},{"key":"2025120618114230000_53.10.784.12","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.3.235"},{"key":"2025120618114230000_53.10.784.13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/bjs.1800730509","volume":"73","year":"1986","journal-title":"Br J Surg"},{"key":"2025120618114230000_53.10.784.14","first-page":"196","volume":"4","year":"1994","journal-title":"Surg Laparosc Endosc"},{"key":"2025120618114230000_53.10.784.15","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.2.122"},{"key":"2025120618114230000_53.10.784.16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.346"},{"key":"2025120618114230000_53.10.784.17","first-page":"43","volume":"58","year":"1995","journal-title":"Acta Gastroenterol Belg"},{"key":"2025120618114230000_53.10.784.18","doi-asserted-by":"publisher","DOI":"10.1177\/0148607195019003182"},{"key":"2025120618114230000_53.10.784.19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/01635589809514689","volume":"31","year":"1998","journal-title":"Nutr Cancer"},{"key":"2025120618114230000_53.10.784.20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.1.15"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.53.10.784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:11:51Z","timestamp":1765073511000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.53.10.784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2000,10,1]]},"published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1136\/jcp.53.10.784"],"URL":"https:\/\/doi.org\/10.1136\/jcp.53.10.784","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}