{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:03:19Z","timestamp":1765728199485,"version":"3.48.0"},"reference-count":44,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To investigate the expression of \u03b1, \u03b2, and \u03b3 catenins in oropharyngeal and hypopharyngeal squamous cell carcinoma and their relations to each other, as well as to clinical data, tumour differentiation, and prognosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Primary tumours for analysis were obtained from 138 patients diagnosed with squamous cell carcinoma of the oropharynx or hypopharynx between 1975 and 1998 in eastern Finland. Immunohistochemistry was used to evaluate the expression of \u03b1, \u03b2, and \u03b3 catenins. The expression patterns of all catenins were related to clinical data and survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014The expression patterns of all three catenins were significantly interrelated. Reduced \u03b3 catenin expression was significantly associated with poor histological differentiation. No association was found between \u03b1 or \u03b2 catenin expression and clinicopathological characteristics. In univariate analysis, patients whose tumours had nuclear \u03b2 catenin expression had shorter overall survival than patients with no nuclear expression. In Cox multivariate analysis, nuclear \u03b2 catenin expression, tumour status (T class), and Karnofsky performance index were independent prognostic factors of overall survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Reduced expression of \u03b3 catenin is associated with dedifferentiation in primary squamous cell carcinoma of the oropharynx and hypopharynx. The fact that nuclear \u03b2 catenin expression independently predicts short overall survival suggests that it might be a valuable prognostic marker in pharyngeal squamous cell carcinoma.\n                  <\/jats:p>","DOI":"10.1136\/jcp.54.1.42","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"42-47","source":"Crossref","is-referenced-by-count":39,"title":["Nuclear \u03b2 catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma"],"prefix":"10.1136","volume":"54","author":[{"given":"M J","family":"Pukkila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Virtaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Kumpulainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R T","family":"Pirinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R T","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Valtonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Juhola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V-M","family":"Kosma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025121407581382000_54.1.42.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00328-1"},{"key":"2025121407581382000_54.1.42.2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/j.1460-2075.1989.tb03563.x","volume":"8","year":"1989","journal-title":"EMBO J"},{"key":"2025121407581382000_54.1.42.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R"},{"key":"2025121407581382000_54.1.42.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(96)80049-4"},{"key":"2025121407581382000_54.1.42.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.20.2527"},{"key":"2025121407581382000_54.1.42.6","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.5.1375"},{"key":"2025121407581382000_54.1.42.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1787"},{"key":"2025121407581382000_54.1.42.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70218-X"},{"key":"2025121407581382000_54.1.42.9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000227681","volume":"54","year":"1997","journal-title":"Oncology"},{"key":"2025121407581382000_54.1.42.10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/jcp.52.1.10","volume":"52","year":"1999","journal-title":"J Clin Pathol"},{"key":"2025121407581382000_54.1.42.11","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1200\/JCO.1998.16.8.2591","volume":"16","year":"1998","journal-title":"J Clin Oncol"},{"key":"2025121407581382000_54.1.42.12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690381"},{"key":"2025121407581382000_54.1.42.13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.12.891"},{"key":"2025121407581382000_54.1.42.14","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/bjc.1997.252","volume":"75","year":"1997","journal-title":"Br J Cancer"},{"key":"2025121407581382000_54.1.42.15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1600-0714.1998.tb01962.x","volume":"27","year":"1998","journal-title":"J Oral Pathol Med"},{"key":"2025121407581382000_54.1.42.16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<8::AID-PATH156>3.0.CO;2-H"},{"key":"2025121407581382000_54.1.42.17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981023)79:5<546::AID-IJC18>3.0.CO;2-#"},{"key":"2025121407581382000_54.1.42.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90123-5"},{"key":"2025121407581382000_54.1.42.19","first-page":"3817","volume":"19","year":"1999","journal-title":"Anticancer Res"},{"key":"2025121407581382000_54.1.42.20","first-page":"1065","volume":"6","year":"1999","journal-title":"Oncol Rep"},{"key":"2025121407581382000_54.1.42.21","unstructured":"UICC. 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