{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:59:55Z","timestamp":1765609195505,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>\n                  <jats:italic>Aims<\/jats:italic>\u2014To investigate whether it is worthwhile, in areas where thalassaemia is common, to screen for globin gene mutations in subjects with a mean corpuscular volume (MCV) above 80 fL, especially in partners of known thalassaemia carriers.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Methods<\/jats:italic>\u2014Blood samples from 95 subjects with MCV between 80 and 85 fL were screened for the presence of \u03b1 globin gene mutations and the haemoglobin (Hb) E mutation.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Results<\/jats:italic>\u2014Thirty four subjects harboured globin gene mutations. Of these, 31 had deletions of one \u03b1 globin gene, one had Hb Constant Spring, and three had Hb E mutations.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Conclusion<\/jats:italic>\u2014Based on the above figures and known prevalence rates of thalassaemia carriers, it would seem worthwhile to screen for globin gene mutations in partners of known thalassaemia carriers, regardless of MCV, to identify pregnancies at risk of Hb H disease or Hb E\/\u03b2 thalassaemia. <\/jats:p>","DOI":"10.1136\/jcp.54.4.317","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"317-320","source":"Crossref","is-referenced-by-count":50,"title":["Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?"],"prefix":"10.1136","volume":"54","author":[{"given":"L C","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Y Y","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Y","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Waye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y L","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H K","family":"Chui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2025092504075421000_54.4.317.1","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1136\/bmj.300.6741.1702","volume":"300","year":"1990","journal-title":"BMJ"},{"key":"2025092504075421000_54.4.317.2","first-page":"453","volume":"5","year":"1993","journal-title":"The Canadian Journal of Obstetrics\/Gynecology and Women's Health Care"},{"key":"2025092504075421000_54.4.317.3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.11.1054"},{"key":"2025092504075421000_54.4.317.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00809.x"},{"key":"2025092504075421000_54.4.317.5","first-page":"215","volume":"23","year":"1989","journal-title":"J R Coll Physicians Lond"},{"key":"2025092504075421000_54.4.317.6","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(93)90186-L"},{"key":"2025092504075421000_54.4.317.7","first-page":"397","volume":"54","year":"1994","journal-title":"Am J Hum Genet"},{"key":"2025092504075421000_54.4.317.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80068-X"},{"key":"2025092504075421000_54.4.317.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80069-1"},{"key":"2025092504075421000_54.4.317.10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1182\/blood.V66.1.224.224","volume":"66","year":"1985","journal-title":"Blood"},{"key":"2025092504075421000_54.4.317.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361805"},{"key":"2025092504075421000_54.4.317.12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/ajh.2830460309","volume":"46","year":"1994","journal-title":"Am J Hematol"},{"key":"2025092504075421000_54.4.317.13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.5.411"},{"key":"2025092504075421000_54.4.317.14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2141.1990.tb07884.x","volume":"76","year":"1990","journal-title":"Br J Haematol"},{"key":"2025092504075421000_54.4.317.15","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1182\/blood.V83.11.3418.3418","volume":"83","year":"1994","journal-title":"Blood"},{"key":"2025092504075421000_54.4.317.16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/03630269208998877","volume":"16","year":"1992","journal-title":"Hemoglobin"},{"key":"2025092504075421000_54.4.317.17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2017.x"},{"key":"2025092504075421000_54.4.317.18","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.4.289"},{"key":"2025092504075421000_54.4.317.19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01221.x"},{"key":"2025092504075421000_54.4.317.20","unstructured":"Orkin SH, Nathan DG. 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