{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:49:23Z","timestamp":1761763763465,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>\n                  <jats:italic>Aim<\/jats:italic>\u2014To review and reassess the role of this department's experience with routine electron microscopy of myocardial tissues.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Methods<\/jats:italic>\u2014A nine year series of myocardial samples that underwent electron microscopy analysis were audited. Fifty nine samples were derived from 46 male and 13 female subjects with an age range of 15\u201390 years (mean, 50.6). Forty two samples were endomyocardial specimens, with 13 being derived from explanted hearts, and four from necropsies. Two cases were from transplanted hearts. These were all reviewed in a blinded fashion, by all three authors separately, in terms of the myocardium at the ultrastructural level. Subsequently, the interpretations\/diagnoses were cross compared with the light microscopy and clinical data results.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Results<\/jats:italic>\u2014Four cases of amyloid were identified; in addition, one case of granulomatous inflammation and one case of basophilic degeneration were seen, although all these had been evident on light microscopy. One case of possible mitochondrial myopathy was found. A total of 18 cases revealed changes of a presumed non-specific type including glycogen, lipid, and mitochondrial accumulations. Varying types of degeneration involving myofibres were seen together with variations in interstitial fibrosis and occasional cytoplasmic inclusions.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Conclusion<\/jats:italic>\u2014Overall, although interesting, the electron microscopy of myocardial tissue added little to the understanding of the patient's disease, with only one case showing changes not found at light microscopy or with other investigations. Further study might shed light on the \u201cnon-specific\u201d ultrastructural findings encountered. <\/jats:p>","DOI":"10.1136\/jcp.54.4.321","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"321-325","source":"Crossref","is-referenced-by-count":18,"title":["Electron microscopy of myocardial tissue. A nine year review"],"prefix":"10.1136","volume":"54","author":[{"given":"H S","family":"Mudhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B E","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Suvarna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2025092506311127000_54.4.321.1","unstructured":"Albala A, Fenoglio JJ. Diagnostic electron microscopy of endomyocardial biopsies. In: Papamidimitrou JM, Henderson DW, Spagnolo DV, eds. Diagnostic ultrastructure of non-neoplastic diseases. Edinburgh: Churchill Livingstone, 1992:254\u20139."},{"key":"2025092506311127000_54.4.321.2","unstructured":"Ferrans VJ, Rodriguez ER. Ultrastructure of the normal heart. In: Silver M, ed. Cardiovascular pathology, 2nd ed. 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Ultrastructural pathology of the cell and matrix, 4th ed. Boston: Butterworth-Heinemann, 1997."},{"key":"2025092506311127000_54.4.321.17","unstructured":"Papamidimitrou JM, Henderson DW, Spagnolo DV. Skeletal muscle. In: Papamidimitrou JM, Henderson DW, Spagnolo DV, eds. Diagnostic ultrastructure of non-neoplastic diseases. Edinburgh: Churchill Livingstone, 1992:595\u20136."},{"key":"2025092506311127000_54.4.321.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-5839(97)80194-7"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.54.4.321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:31:46Z","timestamp":1758807106000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.54.4.321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,4,1]]},"published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1136\/jcp.54.4.321"],"URL":"https:\/\/doi.org\/10.1136\/jcp.54.4.321","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}