{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:57:11Z","timestamp":1774357031897,"version":"3.50.1"},"reference-count":54,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Tuberculosis presenting as an isolated liver tumour, without active pulmonary or miliary tuberculosis, or other clinical evidence of tuberculosis, is distinctly rare. A greater awareness of this rare clinical entity may prevent needless surgical intervention.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To help characterise this distinctly rare presentation of tuberculosis, five new cases are presented, together with a review of the world literature. The clinical, laboratory, radiological, and pathological features of these patients are described.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Polymerase chain reaction (PCR) assay of the liver tissue was carried out in all cases to confirm an aetiological diagnosis of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    All five patients (44\u201371 years old; two women, three men) underwent surgery, and had a preoperative diagnosis of malignant hepatic neoplasm and a postoperative histological diagnosis of chronic granulomatous inflammation, suggestive of tuberculosis. None of them had a known previous history of tuberculosis. All of them were positive for\n                    <jats:italic>M tuberculosis<\/jats:italic>\n                    by PCR analysis of the liver tissue.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This report illustrates the difficulty in reaching a correct preoperative diagnosis. It is usually unsuspected and confused with primary or metastatic carcinoma of the liver, especially when it coexists with other malignancies. A high index of suspicion is required for diagnosis, which can be made only by histological and bacteriological studies, and PCR analysis.\n                  <\/jats:p>","DOI":"10.1136\/jcp.56.11.835","type":"journal-article","created":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T08:30:14Z","timestamp":1068021014000},"page":"835-839","source":"Crossref","is-referenced-by-count":58,"title":["The nodular form of hepatic tuberculosis: a review with five additional new cases"],"prefix":"10.1136","volume":"56","author":[{"given":"W-T","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-C","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W-j","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-F","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-L","family":"Eng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2003,11,4]]},"reference":[{"key":"2025121402375840000_56.11.835.1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.977"},{"key":"2025121402375840000_56.11.835.2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199004000-00011"},{"key":"2025121402375840000_56.11.835.3","unstructured":"Paulson M. 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