{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:51:35Z","timestamp":1789444295930,"version":"build-2803163510"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A prospective database of patients who underwent SLN biopsy for invasive breast cancer from July 1999 to November 2002 (n \u200a=\u200a 180) was analysed. Fifty four patients (30%) had one or more positive SLN, and all underwent a completion axillary dissection. This subgroup was further analysed to delineate which factors predicted non-SLN metastasis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Twenty six of the 54 patients with a positive SLN had additional metastases in non-SLNs. Significant variables that predicted non-SLN metastasis included extranodal extension (odds ratio (OR), 17.399; 95% confidence interval (CI), 1.69 to 178.96) and macrometastasis within the SLN (OR, 6.985; 95% CI, 1.291 to 37.785).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In patients with invasive breast cancer and a positive SLN, extranodal extension or macrometastasis within the SLN were both independent predictors of non-SLN involvement.\n                  <\/jats:p>","DOI":"10.1136\/jcp.57.1.73","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T18:53:07Z","timestamp":1072205587000},"page":"73-76","source":"Crossref","is-referenced-by-count":54,"title":["Factors affecting metastases to non-sentinel lymph nodes in breast cancer"],"prefix":"10.1136","volume":"57","author":[{"given":"F 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