{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:58Z","timestamp":1791497938056,"version":"4.3.4"},"reference-count":42,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Epidemiol Community Health"],"accepted":{"date-parts":[[2014,2,9]]},"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Adverse socioeconomic position (SEP) in childhood and adulthood is associated with a proinflammatory phenotype, and therefore an important exposure to consider for multiple sclerosis (MS), a complex neuroinflammatory autoimmune disease. The objective was to determine whether SEP over the life course confers increased susceptibility to MS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>1643 white, non-Hispanic MS case and control members recruited from the Kaiser Permanente Medical Care Plan, Northern California Region, for which comprehensive genetic, clinical and environmental exposure data have been collected were studied. Logistic regression models investigated measures of childhood and adulthood SEP, and accounted for effects due to established MS risk factors, including <jats:italic>HLA-DRB1*15:01<\/jats:italic> allele carrier status, smoking history, history of infectious mononucleosis, family history of MS and body size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Multiple measures of childhood and adulthood SEP were significantly associated with risk of MS, including <jats:italic>parents renting<\/jats:italic> versus <jats:italic>owning a home at age 10<\/jats:italic>: OR=1.48, 95% CI 1.09 to 2.02, p=0.013; <jats:italic>less than a college education<\/jats:italic> versus <jats:italic>at least a college education based on parental household<\/jats:italic>: OR=1.28, 95% CI 1.01 to 1.63, p=0.041; <jats:italic>low<\/jats:italic> versus <jats:italic>high life course SEP<\/jats:italic>: OR=1.50, 95% CI 1.09 to 2.05, p=0.012; and <jats:italic>low<\/jats:italic> versus <jats:italic>high social mobility<\/jats:italic>: OR=1.74, 95% CI 1.27 to 2.39, p=5.7\u00d710<jats:sup>\u22124<\/jats:sup>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results derived from a population-representative case\u2013control study provide support for the role of adverse SEP in MS susceptibility and add to the growing evidence linking lower SEP to poorer health outcomes. Both genetic and environmental contributions to chronic conditions are important and must be characterised to fully understand MS aetiology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jech-2013-203184","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:28:39Z","timestamp":1393547319000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Adverse socioeconomic position during the life course is associated with multiple sclerosis"],"prefix":"10.1136","volume":"68","author":[{"given":"Farren B S","family":"Briggs","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid S","family":"Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Division of Research, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Division of Research, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliope H","family":"Bellesis","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Division of Research, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia P","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Quach","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Palm Drive Hospital, Sebastopol, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Division of Research, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F","family":"Barcellos","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, California, USA"},{"name":"Kaiser Permanente Division of Research, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"2025100306195527000_68.7.622.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364237"},{"key":"2025100306195527000_68.7.622.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073493"},{"key":"2025100306195527000_68.7.622.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature10251"},{"key":"2025100306195527000_68.7.622.4","first-page":"288","article-title":"Environmental risk factors for multiple sclerosis. 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