{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:59:48Z","timestamp":1781128788486,"version":"3.54.1"},"reference-count":33,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Epidemiol Community Health"],"accepted":{"date-parts":[[2014,12,31]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Few studies have investigated the relationship between carbon monoxide (CO) poisoning and risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). Therefore, we conducted a nationwide longitudinal cohort study in Taiwan to determine whether patients with CO poisoning are associated with increased risk of developing DVT and PE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study investigated the incidence and risk factors for DVT and PE in 8316 patients newly diagnosed with CO poisoning from the Taiwan National Health Insurance Research Database between 2000 and 2011. The comparison cohort contained 33\u2005264 controls without CO poisoning from the general population. Follow-up was initiated on the date of initial diagnosis of CO poisoning and continued until the date of a DVT or PE event, censoring or December 31, 2011. Cox proportional hazard regression models were used to analyse the risk of DVT and PE according to sex, age and comorbidities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The incidences of DVT and PE were higher in the patients with CO poisoning than in the controls (5.67 vs 1.47\/10\u2005000 person-years and 1.97 vs 1.02\/10\u2005000 person-years, respectively). After adjusting for age, sex and comorbidities, the patients with CO poisoning were associated with a 3.85-fold higher risk of DVT compared with the comparison cohort, and non-significantly associated with risk of PE. CO poisoning patients with a coexisting comorbidity or acute respiratory failure were associated with significantly and substantially increased risk of DVT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Risk of DVT is significantly higher in patients with CO poisoning than in the general population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jech-2014-205047","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T23:54:40Z","timestamp":1421970880000},"page":"557-562","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Carbon monoxide poisoning and risk of deep vein thrombosis and pulmonary embolism: a nationwide retrospective cohort study"],"prefix":"10.1136","volume":"69","author":[{"given":"Wei-Sheng","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan"},{"name":"Department of Health Services Administration, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"2025100303420052000_69.6.557.1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1152\/jappl.1992.72.4.1311","article-title":"Rate of formation of carboxyhemoglobin in exercising humans exposed to carbon monoxide","volume":"72","author":"Tikuisis","year":"1992","journal-title":"J Appl Physiol (1985)"},{"key":"2025100303420052000_69.6.557.2","first-page":"183","article-title":"Diagnosis and treatment of carbon monoxide poisoning","volume":"5","author":"Piantadosi","year":"1999","journal-title":"Respir Care Clin N Am"},{"key":"2025100303420052000_69.6.557.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405642101"},{"key":"2025100303420052000_69.6.557.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-557OC"},{"key":"2025100303420052000_69.6.557.5","first-page":"120","article-title":"Risk factors for venous and arterial thrombosis","volume":"9","author":"Previtali","year":"2011","journal-title":"Blood Transfusion"},{"key":"2025100303420052000_69.6.557.6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.5.445"},{"key":"2025100303420052000_69.6.557.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.01.018"},{"key":"2025100303420052000_69.6.557.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60202-0"},{"key":"2025100303420052000_69.6.557.9","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.2012.0115"},{"key":"2025100303420052000_69.6.557.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392206"},{"key":"2025100303420052000_69.6.557.11","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.6.845"},{"key":"2025100303420052000_69.6.557.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808891"},{"key":"2025100303420052000_69.6.557.13","doi-asserted-by":"publisher","DOI":"10.1177\/1534582306289730"},{"key":"2025100303420052000_69.6.557.14","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2425"},{"key":"2025100303420052000_69.6.557.15","doi-asserted-by":"publisher","DOI":"10.1080\/02699050802008075"},{"key":"2025100303420052000_69.6.557.16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.4.398"},{"key":"2025100303420052000_69.6.557.17","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a0064f"},{"key":"2025100303420052000_69.6.557.18","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2012-202152"},{"key":"2025100303420052000_69.6.557.19","doi-asserted-by":"publisher","DOI":"10.1136\/oem.59.10.708"},{"key":"2025100303420052000_69.6.557.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01562.x"},{"key":"2025100303420052000_69.6.557.21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<338::AID-PATH773>3.0.CO;2-4"},{"key":"2025100303420052000_69.6.557.22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000046771.12875.6C"},{"key":"2025100303420052000_69.6.557.23","doi-asserted-by":"crossref","unstructured":"Cheng TM . 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