{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:57:53Z","timestamp":1789189073409,"version":"build-2803163510"},"reference-count":34,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Epidemiol Community Health"],"accepted":{"date-parts":[[2015,3,27]]},"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Systematic reviews of high-quality evidence are used to inform policy and practice. To improve community health, the production of such reviews should align with burden of disease. This study aims to assess if the volume of research output from systematic reviews proportionally aligns with burden of disease assessed using percentages of mortality and disability-adjusted life years (DALYs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional audit of reviews published between January 2012 and August 2013 in the Cochrane Database of Systematic Reviews (CDSR) and Database of Abstracts of Reviews of Effects (DARE) was undertaken. Percentages of mortality and DALYs were obtained from the 2010 Global Burden of Disease study. Standardised residual differences (SRD) based on percentages of mortality and DALYs were calculated, where conditions with SRD of more than or less than three were considered overstudied or understudied, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>1029 reviews from CDSR and 1928 reviews from DARE were examined. There was a significant correlation between percentage DALYs and systematic reviews published in CDSR and DARE databases (CDSR: r=0.68, p=0.001; DARE: r=0.60, p&lt;0.001). There was no significant correlation between percentage mortality and number of systematic reviews published in either database (CDSR: r=0.34, p=0.14; DARE: r=0.22, p=0.34). Relative to percentage of mortality, mental and behavioural disorders, musculoskeletal conditions and other non-communicable diseases were overstudied. Maternal disorders were overstudied relative to percentages of mortality and DALYs in CDSR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The focus of systematic reviews is moderately correlated with DALYs. A number of conditions may be overstudied relative to percentage of mortality particularly in the context of health and medical reviews.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jech-2014-205389","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T22:21:36Z","timestamp":1429309296000},"page":"708-714","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Alignment of systematic reviews published in the Cochrane Database of Systematic Reviews and the Database of Abstracts and Reviews of Effectiveness with global burden-of-disease data: a bibliographic analysis"],"prefix":"10.1136","volume":"69","author":[{"given":"Sze Lin","family":"Yoong","sequence":"first","affiliation":[{"name":"Hunter New England Population Health, Wallsend, New South Wales, Australia"},{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Hall","sequence":"additional","affiliation":[{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Williams","sequence":"additional","affiliation":[{"name":"Hunter New England Population Health, Wallsend, New South Wales, Australia"},{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"},{"name":"The George Institute for Global Health, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Skelton","sequence":"additional","affiliation":[{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Oldmeadow","sequence":"additional","affiliation":[{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wiggers","sequence":"additional","affiliation":[{"name":"Hunter New England Population Health, Wallsend, New South Wales, Australia"},{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chante","family":"Karimkhani","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay N","family":"Boyers","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine, Washington DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P","family":"Dellavalle","sequence":"additional","affiliation":[{"name":"Dermatology Service, U.S. Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado, USA"},{"name":"University of Colorado, School of Medicine, Aurora, Colorado, USA"},{"name":"Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hilton","sequence":"additional","affiliation":[{"name":"Cochrane Editorial Unit, The Cochrane Collaboration, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Wolfenden","sequence":"additional","affiliation":[{"name":"Hunter New England Population Health, Wallsend, New South Wales, Australia"},{"name":"The University of Newcastle, School of Medicine and Public Health, Callaghan, New South Wales, Australia"},{"name":"Hunter Medical Research Institute, New Lambton, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"2025100302213896000_69.7.708.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7040.1215"},{"key":"2025100302213896000_69.7.708.2","first-page":"778","article-title":"Research synthesis and dissemination as a bridge to knowledge management: the Cochrane Collaboration","volume":"82","author":"Volmink","year":"2004","journal-title":"Bull World Health Organ"},{"key":"2025100302213896000_69.7.708.3","unstructured":"Centre for Reviews and Dissemination. Systematic review: CRD's guidance for undertaking reviews in health care. York: University of York, 2009."},{"key":"2025100302213896000_69.7.708.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_2-200506211-00002"},{"key":"2025100302213896000_69.7.708.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000141"},{"key":"2025100302213896000_69.7.708.6","first-page":"e21704","article-title":"The use of research evidence in public health decision making processes: systematic review","volume":"6","author":"Orton","year":"2011","journal-title":"PLoS Med"},{"key":"2025100302213896000_69.7.708.7","unstructured":"Institute of Medicine Committee on the NIH Research Priority-Setting Process. Scientific opportunities and public needs: improving priority setting and public input at the National Institutes of Health. National Academies Press, 1998."},{"key":"2025100302213896000_69.7.708.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402406"},{"key":"2025100302213896000_69.7.708.9","unstructured":"Australian Institute of Health and Welfare. Burden of Disease. Secondary Burden of Disease [Internet]. 2015. http:\/\/www.aihw.gov.au\/burden-of-disease\/"},{"key":"2025100302213896000_69.7.708.10","unstructured":"World Health Organization. Mortality and global health estimates. http:\/\/www.who.int\/gho\/mortality_burden_disease\/en\/ (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.11","unstructured":"World Health Organization. Metrics: Disability-Adjusted Life Year (DALY). http:\/\/www.who.int\/healthinfo\/global_burden_disease\/metrics_daly\/en\/ (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.12","unstructured":"Cochrane Agenda and Priority Setting Methods Group. 2014. https:\/\/capsmg.cochrane.org\/global-burden-disease-gbd-cochrane-project (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.13","first-page":"792519","article-title":"Translational science and evidence-based healthcare: a clarification and reconceptualization of how knowledge is generated and used in healthcare","volume":"2012","author":"Pearson","year":"2012","journal-title":"Nurs Res Pract"},{"key":"2025100302213896000_69.7.708.14","unstructured":"The Campbell Collaboration. About us. http:\/\/www.campbellcollaboration.org\/about_us\/index.php (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7423.1083"},{"key":"2025100302213896000_69.7.708.16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090147"},{"key":"2025100302213896000_69.7.708.17","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.709"},{"key":"2025100302213896000_69.7.708.18","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2013","journal-title":"Lancet"},{"key":"2025100302213896000_69.7.708.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"2025100302213896000_69.7.708.20","unstructured":"Institute for Health Metrics and Evaluation (IHME). GBD Cause Patterns. 2014."},{"key":"2025100302213896000_69.7.708.21","unstructured":"Allen C , Brurgess M , Clarke M , et al . International activity within Cochrane Review Groups. The Cochrane Collaboration, 2014."},{"key":"2025100302213896000_69.7.708.22","unstructured":"Global Burden of Diseases, Injuries, and Risk Factors Study. 2013. http:\/\/www.thelancet.com\/themed\/global-burden-of-disease (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.23","unstructured":"Web table 3- List of International Classification of Diseases codes mapped to the Global Burden of Disease cause list. http:\/\/www.healthdata.org\/sites\/default\/files\/files\/data_for_download\/2012\/IHME_GBD2010_CauseListandICD.pdf (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.24","unstructured":"SAS Institute. The SAS system for Windows. Release 9.4. Cary, NC: SAS Institute, 2011."},{"key":"2025100302213896000_69.7.708.25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016837"},{"key":"2025100302213896000_69.7.708.26","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3527"},{"key":"2025100302213896000_69.7.708.27","first-page":"83","article-title":"Association between the burden of disease and research funding by the Medical Research Council of Canada and the National Institutes of Health. A cross-sectional study","volume":"24","author":"Lamarre-Cliche","year":"2001","journal-title":"Clin Invest Med"},{"key":"2025100302213896000_69.7.708.28","unstructured":"National Health Priority Areas. 2014. https:\/\/www.nhmrc.gov.au\/grants\/research-funding-statistics-and-data\/national-health-priority-areas-nhpas-datasets (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.29","unstructured":"Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC). 2014. http:\/\/report.nih.gov\/categorical_spending.aspx (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.30","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000036571.00320.b8"},{"key":"2025100302213896000_69.7.708.31","unstructured":"Cochrane Pregnancy and Childbirth Group. WHO announces forthcoming updated guidelines for preventing and treating PPH. 2012. http:\/\/pregnancy.cochrane.org\/node\/69 (accessed Sep 2014)."},{"key":"2025100302213896000_69.7.708.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.01.001"},{"key":"2025100302213896000_69.7.708.33","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2567"},{"key":"2025100302213896000_69.7.708.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.09.005"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech-2014-205389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:21:54Z","timestamp":1759483314000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech-2014-205389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,17]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,6,10]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1136\/jech-2014-205389"],"URL":"https:\/\/doi.org\/10.1136\/jech-2014-205389","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"value":"0143-005X","type":"print"},{"value":"1470-2738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,17]]}}}