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This study identified gender-specific aspects of socialisation associated with CVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A longitudinal study was conducted, involving 9936 (5,231 women and 4705 men) initially healthy, community-dwelling Australians aged 70 years or more from the ASPirin in Reducing Events in the Elderly (ASPREE) study and ASPREE Longitudinal Study of Older Persons, with a median follow-up time of 6.4 years. Variable categorisation, variable selection (using machine learning (ML) models; Elastic Net and extreme gradient boosting) and Cox-regression were employed separately by binary gender to identity socialisation factors (n=25 considered) associated with CVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Different socialisation factors were identified using the ML models. In the Cox model, for both genders, being married\/partnered was associated with a reduced risk of CVD (men: HR 0.76, 95% CI 0.60 to 0.96; women: HR 0.67, 95% CI 0.58 to 0.95). For men, having 3\u20138 relatives they felt close to and could call on for help (HR 0.76, 95% CI 0.58 to 0.99; reference &lt;3 relatives), having 3\u20138 relatives they felt at ease talking with about private matters (HR 0.70, 95% CI 0.55 to 0.90; reference &lt;3 relatives) or playing games such as chess or cards (HR 0.82, 95% CI 0.67 to 1.00) was associated with reduced risk of CVD. For women, living with others (HR 0.71, 95% CI 0.55 to 0.91) or having \u22653 friends they felt at ease talking with about private matters (HR 0.74, 95% CI 0.58 to 0.95; reference &lt;3 friends) was associated with a lower risk of CVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrates the need to prioritise gender-specific social factors to improve cardiovascular health in older adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jech-2023-221860","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:05:30Z","timestamp":1717585530000},"page":"737-744","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Gender-specific aspects of socialisation and risk of cardiovascular disease among community-dwelling older adults: a prospective cohort study using machine learning algorithms and a conventional method"],"prefix":"10.1136","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9993","authenticated-orcid":false,"given":"Achamyeleh Birhanu","family":"Teshale","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-0610","authenticated-orcid":false,"given":"Htet Lin","family":"Htun","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-6069","authenticated-orcid":false,"given":"Alice J.","family":"Owen","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, 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Medicine, Monash University, Melbourne, Victoria, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Food & Mood Centre, School of Medicine, Deakin University and Barwon Health, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-0610","authenticated-orcid":false,"given":"Andrew","family":"Tonkin","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes T","family":"Neumann","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"},{"name":"Department of Cardiology, University Heart & Vascular Centre, Hamburg, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site 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