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Less is known about the effects of physical health conditions with different progression and level of impairment on spousal mental health among younger people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Finnish total population register data, we identified 106\u2009673 partnered individuals aged 30\u201370, newly diagnosed in 2000\u20132015 with progressive conditions with increasing impairment (Parkinson\u2019s disease, multiple sclerosis, dementia), acute conditions with sudden impairment (stroke) and acute conditions without cognitive impairment (myocardial infarction, prostate cancer, female breast cancer), and employed event\u2013study difference-in-difference models to assess short-term and long-term effects on spouses\u2019 6-month probability of psychotropic medication purchases (Anatomical Therapeutic Chemical (ATC) codes N05B, N05C and N06A) by type of health condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incident stroke had a sudden effect on spousal psychotropic medication purchase probability (2.1\u2009percentage points increase among female and 1.4\u2009percentage points increase among male spouses). Effect size attenuated thereafter, although more slowly among female spouses, yet remained over 1\u2009percentage point in the long term. Smaller (about 0.7\u2009percentage points among female and 0.5\u2009percentage points among male spouses), but also persistent, effect was observed following the diagnosis of acute conditions without cognitive impairments. For progressive conditions, little changes occurred around the time of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute onset of physical illness may have sudden and persistent adverse impact on spousal mental health in midlife even when prognosis is good and expectations for spousal care are likely to be limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jech-2025-223966","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:20:37Z","timestamp":1762885237000},"page":"158-166","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Physical illness and changes in spousal mental health: a register-based study on Finnish couples aged 30\u201370"],"prefix":"10.1136","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-3980","authenticated-orcid":false,"given":"Niina","family":"Mets\u00e4-Simola","sequence":"first","affiliation":[{"name":"Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland"},{"name":"Max Planck \u2013 University of Helsinki Center for Social Inequalities in Population Health, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7806-6921","authenticated-orcid":false,"given":"Lotta","family":"Volotinen","sequence":"additional","affiliation":[{"name":"Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland"},{"name":"Max Planck \u2013 University of Helsinki Center for Social Inequalities in Population Health, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-1438","authenticated-orcid":false,"given":"Pekka","family":"Martikainen","sequence":"additional","affiliation":[{"name":"Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland"},{"name":"Max Planck \u2013 University of Helsinki Center for Social Inequalities in Population Health, University of Helsinki, Helsinki, Finland"},{"name":"Max-Planck-Institute for Demographic Research, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"2026021003052572000_80.3.158.1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijnurstu.2015.10.016","article-title":"Family caregivers of patients with frontotemporal dementia: An integrative review","volume":"55","author":"Caceres","year":"2016","journal-title":"Int J Nurs Stud"},{"key":"2026021003052572000_80.3.158.2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jamda.2016.08.014","article-title":"The Global Prevalence of Anxiety and Depressive Symptoms Among Caregivers of Stroke Survivors","volume":"18","author":"Loh","year":"2017","journal-title":"J Am Med Dir Assoc"},{"key":"2026021003052572000_80.3.158.3","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011863","article-title":"Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis","volume":"97","author":"Geng","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2026021003052572000_80.3.158.4","doi-asserted-by":"crossref","first-page":"100196","DOI":"10.1016\/j.jeoa.2019.100196","article-title":"Health effects of caring for and about parents and spouses","volume":"14","author":"Bom","year":"2019","journal-title":"J Econ Ageing"},{"key":"2026021003052572000_80.3.158.5","doi-asserted-by":"crossref","unstructured":"Hank K , Steinbach A . 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