{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:42Z","timestamp":1789581762334,"version":"build-2803163510"},"reference-count":37,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Epidemiol Community Health"],"accepted":{"date-parts":[[2026,8,28]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated whether socioeconomic status (SES), life-course reserve-related indicator strata and behavioural engagement patterns were independently and jointly associated with incident all-cause dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 500\u2009846 dementia-free UK Biobank participants recruited in 2006\u20132010\u2009and followed to September 2024. SES was defined using household income and Townsend Deprivation Index. Educational attainment and occupational complexity were cross-classified into four life-course reserve-related indicator strata. Behavioural engagement patterns were derived by latent class analysis of television viewing, confiding, social connection and leisure-activity diversity. Cox models adjusted for age, sex, ethnicity and APOE \u03b54 carrier status. Multiplicative interaction was assessed using product terms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a mean 14.9-year follow-up (SD 2.5), 9813 participants developed dementia. Higher SES was associated with lower dementia risk (HR per unit higher SES score, 0.71; 95%\u2009CI 0.69 to 0.74). Compared with lower education and lower occupational complexity, higher education with lower complexity occupation (HR 0.91; 95%\u2009CI 0.84 to 0.98)\u2009and higher education with higher complexity occupation (HR 0.87; 95%\u2009CI 0.81 to 0.93) were associated with lower risk. The relatively higher-engagement behavioural pattern was associated with lower dementia risk than the lower-engagement pattern (HR 0.83; 95%\u2009CI 0.80 to 0.87). The association of behavioural engagement patterns with dementia did not differ across SES or life-course reserve-related strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SES, life-course reserve-related indicators and behavioural engagement represent related but distinct dimensions of dementia risk. Behavioural engagement may be relevant across socioeconomic and life-course contexts, while structural conditions shape participation opportunities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jech-2026-226421","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:20:24Z","timestamp":1789579224000},"page":"jech-2026-226421","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Socioeconomic status, life-course reserve-related indicator strata, reserve-related behavioural engagement patterns and incident dementia risk: a prospective UK Biobank study"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-6750","authenticated-orcid":false,"given":"Yihui","family":"Cai","sequence":"first","affiliation":[{"name":"The Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People's Republic of 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L S","family":"Chan","sequence":"additional","affiliation":[{"name":"The Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Macau, Macau, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarou","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People's Republic of 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