{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:24:48Z","timestamp":1770992688745,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To ascertain if infectious mononucleosis is a risk factor for the development of multiple sclerosis (MS); and, if it is, whether its effect is close to or remote in time from the onset of MS.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Analysis of database of linked abstracts of records of hospital admission and death.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Health region in central southern England.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main outcome measure:<\/jats:bold> Ratio of rate of MS in a cohort of people admitted to hospital with infectious mononucleosis to the rate in a comparison cohort.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Considering all time intervals from admission with infection to admission with MS, there was a non-significant increase of risk of MS in the infectious mononucleosis cohort (rate ratio 2.17, 95% confidence intervals 0.79 to 4.77). At the interval of 10 years or more, there was a significant increase in risk of MS (rate ratio 4.01, 1.48 to 8.93). The mean time from infectious mononucleosis to first admission with MS was 14 years.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> This study adds support to the evidence that Epstein-Barr virus, the cause of infectious mononucleosis, is associated with MS. Its role is probably as an initiator of the disease process of MS, or as a contributor to its early development, rather than as an activator of latent, existing disease.<\/jats:p>","DOI":"10.1136\/jech.2003.018366","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T13:28:21Z","timestamp":1100611701000},"page":"1032-1035","source":"Crossref","is-referenced-by-count":50,"title":["Multiple sclerosis after infectious mononucleosis: record linkage study"],"prefix":"10.1136","volume":"58","author":[{"given":"Michael J","family":"Goldacre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare J","family":"Wotton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Seagroatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yeates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,11,16]]},"reference":[{"key":"2025100522442624000_58.12.1032.1","doi-asserted-by":"crossref","unstructured":"Dean G. 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