{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:23:23Z","timestamp":1778217803243,"version":"3.51.4"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[2008,7]]},"abstract":"\n Background:<\/jats:title>\n IgE-mediated hypersensitivity reactions to Anisakis simplex<\/jats:italic> have been described after ingestion of fish, suggesting that sensitisation to this parasite may induce acute urticaria and anaphylaxis. Anisakis simplex<\/jats:italic> allergens are highly resistant to heat and freezing, and sensitisation may occur even in populations with low consumption of raw\/undercooked fish. This study aimed to quantify the association between sensitisation to A. simplex<\/jats:italic> and relapsing acute urticaria.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This is the first case\u2013control study on this topic. Cases (n\u200a=\u200a200) were patients with a clinical diagnosis of relapsing acute urticaria, consecutively approached at the immunoallergology unit of Porto\u2019s largest paediatric hospital. Controls (n\u200a=\u200a200) were consecutively selected at the surgery department of the same hospital, from subjects undergoing programmed orthopaedic, maxillofacial or general surgical procedures. Specific IgE measurements (Anisakis<\/jats:italic> and Ascaris<\/jats:italic>) were taken, and skin-prick tests (A simplex<\/jats:italic>, common aeroallergens, fish, and Ascaris<\/jats:italic>) were done.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Sensitisation to A simplex<\/jats:italic> (OR 3.86, 95% CI 2.04% to 7.29%), Ascaris<\/jats:italic> (OR 3.37, 95% CI 1.89% to 6.02%), fish (OR 4.62, 95% CI 1.85% to 11.52%), and at least one aeroallergen (OR 4.59, 95% CI 2.99% to 7.05%) were associated with increased risk of acute urticaria. Regarding the sensitisation to A simplex<\/jats:italic>, the aeroallergen sensitisation-adjusted OR was 2.61 (95% CI 1.33% to 5.12%) for the whole sample, and 2.72 (95% CI 0.99% to 7.47%) for those not sensitised to Ascaris<\/jats:italic> or fish.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Sensitisation to A simplex<\/jats:italic> increases the risk of relapsing acute urticaria in subjects not sensitised to Ascaris<\/jats:italic> or fish, and this is independent of aeroallergen sensitisation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jech.2007.061572","type":"journal-article","created":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T13:48:45Z","timestamp":1213624125000},"page":"634-637","source":"Crossref","is-referenced-by-count":25,"title":["Anisakis simplex<\/i> as a risk factor for relapsing acute urticaria: a case\u2013control study"],"prefix":"10.1136","volume":"62","author":[{"given":"H","family":"Falc\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Lunet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Igl\u00e9sias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,6,16]]},"reference":[{"key":"2025100702282889000_62.7.634.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)02152-3"},{"key":"2025100702282889000_62.7.634.2","first-page":"240","article-title":"[Heat stability of Anisakis simplex allergens].","volume":"15","author":"Ochoa Baeza","year":"2000","journal-title":"Alergologia e Inmunologia Clinica"},{"key":"2025100702282889000_62.7.634.3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.13429.x"},{"key":"2025100702282889000_62.7.634.4","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.1.115-118.2004"},{"key":"2025100702282889000_62.7.634.5","first-page":"258","article-title":"Anisakis simplex allergy after eating chicken meat.","volume":"16","author":"Armentia","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2025100702282889000_62.7.634.6","first-page":"315","article-title":"Anisakis simplex induces not only anisakiasis: report on 28 cases of allergy caused by this nematode.","volume":"6","author":"Fernandez de Corres","year":"1996","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2025100702282889000_62.7.634.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02418.x"},{"key":"2025100702282889000_62.7.634.8","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948167"},{"key":"2025100702282889000_62.7.634.9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1157\/13070606","article-title":"Allergy and parasites reevaluated: wide-scale induction of chronic urticaria by the ubiquitous fish-nematode Anisakis simplex in an endemic region.","volume":"33","author":"Daschner","year":"2005","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2025100702282889000_62.7.634.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02590.x"},{"key":"2025100702282889000_62.7.634.11","first-page":"48","article-title":"The European Academy of Allergology and Clinical Immunology.","volume":"48","author":"Position paper: Allergen standardization and skin tests","year":"1993","journal-title":"Allergy"},{"key":"2025100702282889000_62.7.634.12","first-page":"339","article-title":"Is Anisakis simplex responsible for chronic urticaria?","volume":"24","author":"Lopez-Saez","year":"2003","journal-title":"Allergy Asthma Proc"},{"key":"2025100702282889000_62.7.634.13","doi-asserted-by":"publisher","DOI":"10.1080\/00034980050006447"},{"key":"2025100702282889000_62.7.634.14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-4632.2006.03090.x","article-title":"Anisakis simplex and cross-reacting antigens.","volume":"46","author":"Weiler","year":"2007","journal-title":"Int J Dermatol"},{"key":"2025100702282889000_62.7.634.15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1398-9995.1997.tb02594.x","article-title":"Cross-reactivity between IgE-binding proteins from Anisakis, German cockroach, and chironomids.","volume":"52","author":"Pascual","year":"1997","journal-title":"Allergy"},{"key":"2025100702282889000_62.7.634.16","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00798.x"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.2007.061572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T09:28:40Z","timestamp":1759829320000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.2007.061572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,16]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2008,6,16]]},"published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1136\/jech.2007.061572"],"URL":"https:\/\/doi.org\/10.1136\/jech.2007.061572","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"value":"0143-005X","type":"print"},{"value":"1470-2738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,16]]}}}