{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T02:16:43Z","timestamp":1768097803071,"version":"3.49.0"},"reference-count":32,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bayingnormen is a region located in western Inner Mongolia China, with a population that is exposed to a wide range of drinking water arsenic concentrations. The relationship between maternal drinking water arsenic exposure and perinatal endpoints (term birth weight, preterm birth, stillbirth and neonatal death) in this region was evaluated in this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An analysis was conducted of all singleton deliveries in a defined geographical area of Inner Mongolia from December 1996 to December 1999 (n=9890). Outcome and covariate data were abstracted from prenatal care records. Exposure was based on well-water measures for the maternal subvillage. Mean birth weight at term was compared across four arsenic categories using analysis of covariance. ORs for stillbirth, preterm birth and neonatal death were estimated by logistic regression with arsenic exposure dichotomised at 50\u2005\u03bcg\/l.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Term birth weight was 0.05\u2005kg higher (95% CI 0.02 to 0.08) in the highest exposure category (&gt;100\u2005\u03bcg\/l) compared to the reference (below limit of detection to 20\u2005\u03bcg\/l). Arsenic &gt;50\u2005\u03bcg\/l was associated with an increased risk of neonatal death (OR 2.01, 95% CI 1.12 to 3.59). No relationship was found between maternal arsenic exposure and preterm or stillbirth delivery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>At the levels observed in our study, arsenic does not appear to contribute to adverse birth outcomes. Exposure may play a role in neonatal death; however, the neonatal death rate in this population was low and this potential association merits further research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jech.2008.084392","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T20:13:40Z","timestamp":1250799220000},"page":"325-329","source":"Crossref","is-referenced-by-count":71,"title":["Maternal drinking water arsenic exposure and perinatal outcomes in Inner Mongolia, China"],"prefix":"10.1136","volume":"64","author":[{"given":"S L","family":"Myers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Lobdell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Mumford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mendola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,8,19]]},"reference":[{"key":"2025100302255012000_64.4.325.1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390242007"},{"key":"2025100302255012000_64.4.325.2","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for arsenic. Atlanta (GA): US Department of Health and Human Services, 2007:73\u2013192."},{"key":"2025100302255012000_64.4.325.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072375"},{"key":"2025100302255012000_64.4.325.4","unstructured":"US Environmental Protection Agency. Arsenic and clarifications to compliance and new source contaminants monitoring final rule. Fed Regist 2001:6975\u20137066."},{"key":"2025100302255012000_64.4.325.5","unstructured":"National Research Council (NRC). Arsenic in drinking water. Washington, DC: National Academy Press, 1999:83\u2013149."},{"key":"2025100302255012000_64.4.325.6","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2002.1573"},{"key":"2025100302255012000_64.4.325.7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/15287398809531221","article-title":"Uptake, distribution, and metabolism of trivalent arsenic in the pregnant mouse","volume":"25","author":"Hood","year":"1988","journal-title":"J Toxicol Environ Health"},{"key":"2025100302255012000_64.4.325.8","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1289\/ehp.9906","article-title":"Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal\u2013newborn pairs","volume":"115","author":"Hall","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2025100302255012000_64.4.325.9","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/44.2.185"},{"key":"2025100302255012000_64.4.325.10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/10937409809524552","article-title":"Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns","volume":"1","author":"Golub","year":"1998","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"2025100302255012000_64.4.325.11","doi-asserted-by":"publisher","DOI":"10.1080\/10915810600840776"},{"key":"2025100302255012000_64.4.325.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000072104.65240.69"},{"key":"2025100302255012000_64.4.325.13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0013-9351(02)00015-4","article-title":"Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in northeastern Taiwan","volume":"91","author":"Yang","year":"2003","journal-title":"Environ Res"},{"key":"2025100302255012000_64.4.325.14","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000147105.94041.e6"},{"key":"2025100302255012000_64.4.325.15","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm025"},{"key":"2025100302255012000_64.4.325.16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1289\/ehp.01109629","article-title":"Arsenic in drinking water and pregnancy outcomes","volume":"109","author":"Ahmad","year":"2001","journal-title":"Environ Health Perspect"},{"key":"2025100302255012000_64.4.325.17","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj089"},{"key":"2025100302255012000_64.4.325.18","doi-asserted-by":"crossref","unstructured":"Ma H Xia Y Wu K . Human exposure to arsenic and health effects in Bayingnormen, Inner Mongolia. In: Chappell W Abernathy C Calderon R , eds. Arsenic exposure and health effects. Amsterdam: Elsevier, 1999:127\u201331.","DOI":"10.1016\/B978-008043648-7\/50016-9"},{"key":"2025100302255012000_64.4.325.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.02.012"},{"key":"2025100302255012000_64.4.325.20","doi-asserted-by":"publisher","DOI":"10.1080\/10934520701566918"},{"key":"2025100302255012000_64.4.325.21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2166\/wh.2006.0002","article-title":"Neurosensory effects of chronic exposure to arsenic via drinking water in Inner Mongolia: I. 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Neonatal and perinatal mortality: country, regional and global estimates. Geneva: WHO Press, 2006."},{"key":"2025100302255012000_64.4.325.32","unstructured":"Yu G Ma H Wu K . Investigations of environmental arsenic in arsenicism endemic area of Inner Mongolia. Journal of Chinese Endemic Diseases, Special Supplement 1995;10\u201314."}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.2008.084392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:26:02Z","timestamp":1759483562000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.2008.084392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,19]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,3,26]]},"published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1136\/jech.2008.084392"],"URL":"https:\/\/doi.org\/10.1136\/jech.2008.084392","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"value":"0143-005X","type":"print"},{"value":"1470-2738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,19]]}}}