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Ibid., 12, 115 (Congenital malformations of the central nervous system in Scotland). (1961). Ann. hum. Genet., 25, 89 (Seasonal incidence of congenital disease in Birmingham).","journal-title":"Ibid"},{"key":"ref_12","first-page":"153","article-title":"(Declining incidence of central nervous system anomalies in New York State)","volume":"16","author":"Gittlesohn, A.M.; Milham, S.","year":"1962","unstructured":"Gittlesohn, A. M., and Milham, S. (1962). Brit. J. prev. soc. Med., 16, 153 (Declining incidence of central nervous system anomalies in New York State).","journal-title":"Brit. J. prev. soc. Med"},{"key":"ref_13","first-page":"p.","article-title":"Causes and morphogenesis of anencephaly\", in \"Ciba Foundation Symposium on Congenital Malformations","author":"Giroud, A.","year":"1960","unstructured":"Giroud, A. (1960). \"Causes and morphogenesis of anencephaly\", in \"Ciba Foundation Symposium on Congenital Malformations\", ed. G. E. W. Wolstenholme and C. M. O'Connor, p. 199. 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