{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:38:36Z","timestamp":1759538316539,"version":"build-2065373602"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>An evaluation of voluntary prenatal screening for neural tube defects with serum alphafetoprotein (s-AFP) is presented. During a three year period, there were 52 fetuses with neural lesions. Of 46 mothers who bore a fetus with an open neural lesion, 25 were detected, of whom 23 agreed to the termination of their pregnancies. An unscreened group of 2331 mothers (17% of all deliveries) produced 14 fetuses with neural tube defects, an incidence of 6.0 per 1000, 1.8 times the incidence (3.3 per 1000) in the screened group. Pitfalls occurring in the assessment of hyper-alphafetoproteinemia included inaccurate gestational dating and allowance for excessive body weight. The results of a robust AFP-NTD screening programme supported in selected cases by ultrasonar visualisation of the spine argue for its continuance in this district.<\/jats:p>","DOI":"10.1136\/jech.37.3.221","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:09:01Z","timestamp":1226502541000},"page":"221-225","source":"Crossref","is-referenced-by-count":3,"title":["Prevention of neural tube defects in an urban health district."],"prefix":"10.1136","volume":"37","author":[{"given":"D","family":"Watson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ellam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Costeloe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"article-title":"Working Group on the Screening for Neural Tube Defects. Report","year":"1979","key":"ref_1","unstructured":"Working Group on the Screening for Neural Tube Defects. Report. London: Department of Health & Social Security. 1979. (Black report.)"},{"key":"ref_2","first-page":"1323","article-title":"Report ofUK Collaborative Study on a-foetoprotein in relation to ENTD. Maternal serum a-foetoprotein measurement in antenatal screening for anencephay and spina bifida in early pregnancy","volume":"n:","author":"First","year":"1977","unstructured":"First Report ofUK Collaborative Study on a-foetoprotein in relation to ENTD. Maternal serum a-foetoprotein measurement in antenatal screening for anencephay and spina bifida in early pregnancy. Lancet 1977; n: 1323-32.","journal-title":"Lancet"},{"key":"ref_3","first-page":"213","article-title":"An optimised radioimmunoassay for maternal serum afoetoprotein using polyethylene glycol","volume":"15","author":"Khadempour, M.H.; Laing, I.; Gowenlock, A.H.","year":"1978","unstructured":"Khadempour MH, Laing I, Gowenlock AH. An optimised radioimmunoassay for maternal serum afoetoprotein using polyethylene glycol. Ann Clin. Biochem 1978; 15: 213-20. 'American College of Obstetrics and Gynecologists and American Academy of Pediatrics. AFP task force report. Washington: US Food & Drug Administration, 1979.","journal-title":"Ann Clin. Biochem; American College of Obstetrics and Gynecologists and American Academy of Pediatrics. AFP task force report"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(76)91880-8","article-title":"Diagnostic reagents for alphafetoprotein","volume":"i:","author":"Watson, D.; Pow, M.","year":"1976","unstructured":"Watson D, Pow M. Diagnostic reagents for alphafetoprotein. Lancet 1976; i: 1015.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/clinchem\/27.1.133","article-title":"Relation between maternal weight and serum alphafetoprotein concentration during the second trimester","volume":"27","author":"Haddow, J.E.; Kloza, E.M.; Knight, G.J.; Smith, D.E.","year":"1981","unstructured":"Haddow JE, Kloza EM, Knight GJ, Smith DE. Relation between maternal weight and serum alphafetoprotein concentration during the second trimester. Clin Chem 1981; 27: 133-4.","journal-title":"Clin Chem"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1136\/bmj.280.6225.1199","article-title":"Maternal serum alphafetoprotein in pregnancy and the prevention of birth defects","volume":"280","author":"Harris, R.","year":"1980","unstructured":"Harris R. Maternal serum alphafetoprotein in pregnancy and the prevention of birth defects. Br Med J 1980; 280: 1199-202.","journal-title":"Br Med J"},{"year":"1970","author":"Chamberlain, R.","key":"ref_7","unstructured":"Chamberlain R, ed. British births. Vol 1. London: Heinemann, 1970."},{"key":"ref_8","first-page":"981","article-title":"Precision in estimating gestational age and its influence on sensitivity of alphafetoprotein screening","volume":"i:","author":"true","year":"1979","unstructured":"Roberts CJ, Hibbard BM, Evans DR, et al. Precision in estimating gestational age and its influence on sensitivity of alphafetoprotein screening. Br MedJ 1979; i: 981-3.","journal-title":"Br MedJ"},{"key":"ref_9","first-page":"319","article-title":"Prenatal detection of neural tube defects by maternal serum alphafetoprotein assay","volume":"60","author":"Grace, H.J.; Gray, R.; Conradie, J.D.","year":"1981","unstructured":"Grace HJ, Gray R, Conradie JD. Prenatal detection of neural tube defects by maternal serum alphafetoprotein assay. S Afr Med J 1981; 60: 319-24.","journal-title":"S Afr Med J"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.37.3.221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:57:53Z","timestamp":1759496273000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.37.3.221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1983,9,1]]},"published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1136\/jech.37.3.221"],"URL":"https:\/\/doi.org\/10.1136\/jech.37.3.221","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}