{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:03:25Z","timestamp":1761512605211,"version":"build-2065373602"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>The Ukinga and Uwanji regions, located in the southern highlands of Tanzania, were studied for the degree of iodine deficiency and the incidence of goitre and hypothyroidism, respectively. A urinary iodine excretion as low as 17.6 +\/- 9.3 micrograms\/g creatinine was observed in Wangama village. The mean goitre prevalence in 27 villages in Uwanji ranged between 65 and 96% (n = 3031 schoolchildren). Of 681 pregnant women from Ukinga 79.6% had goitre. The prevalence of cretinism as estimated on clinical criteria was 3% in Magoye (Uwanji). A normal serum TSH (below 2.1 mU\/l) was observed in only 12 out of 66 school children before iodine prophylaxis, whereas the T4\/TBG ratio was decreased in 36 of 63 cases. Blood spot TSH levels in newborn infants (n = 219) from mothers without iodine supplementation were above 12 mU\/l in 45%. In contrast, only 20.3% of the newborn (n = 118) had elevated blood spot TSH (p less than 0.002) when the mothers had received an iodised oil injection during pregnancy. Most of the newborn (n = 18; 75%) of the latter group with elevated TSH (n = 24) came from mothers who had received the iodine injection only 1-25 days before delivery. Maternal iodine prophylaxis in late pregnancy does not increase the rate of neonatal hypothyroidism. Conclusions: It has been confirmed that severe iodine deficiency resulting in endemic goitre, cretinism, and hypothyroidism is prevalent in the regions studied. Dried blood spot TSH determinations may serve as an index for the efficiency of iodine prophylaxis programmes. Such a programme was carried out with relatively little expenditure and effort on a large scale basis.<\/jats:p>","DOI":"10.1136\/jech.39.3.263","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:09:01Z","timestamp":1226502541000},"page":"263-270","source":"Crossref","is-referenced-by-count":8,"title":["Iodine deficiency, hypothyroidism, and endemic goitre in southern Tanzania. A survey showing the positive effects of iodised oil injections by TSH determination in dried blood spots."],"prefix":"10.1136","volume":"39","author":[{"given":"W","family":"W\u00e4chter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Mvungi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Triebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"van Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Marschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W G","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Habermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R","family":"Pickardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Scriba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/adc.52.2.89","article-title":"Ermans A M. Serum thyrotrophin determination on day 5 of life as screening procedure for congenital hypothyroidism","volume":"52","author":"Delange, F.; Camus, M.; Winkler, M.; Dodion, J.","year":"1977","unstructured":"Delange F, Camus M, Winkler M, Dodion J, Ermans A M. Serum thyrotrophin determination on day 5 of life as screening procedure for congenital hypothyroidism. Arch Dis Child 1977, 52: 89-96.","journal-title":"Arch Dis Child"},{"key":"ref_2","article-title":"Nutritional factors involved in the goitrogenic action of Cassava. IDRC-194 e","author":"Delange, F.; Iteke, S.B.; Ermans, A.M.","year":"1982","unstructured":"Delange F, Iteke SB, Ermans AM. Nutritional factors involved in the goitrogenic action of Cassava. IDRC-194 e, Ottowa, Ontario, 1982."},{"key":"ref_3","article-title":"Endemic goiter and cretinism: Continuing threats to world health","volume":"292","author":"Dunn, J.T.; Medeiros-Neto, G.A.","year":"1974","unstructured":"Dunn JT, Medeiros-Neto GA. Endemic goiter and cretinism: Continuing threats to world health. Pan American Health Organization Scientific Publication no. 292, 1974.","journal-title":"Pan American Health Organization Scientific Publication"},{"key":"ref_4","first-page":"381","article-title":"Verbesserung und Qualitatskontrolle der radioimmunologischen Thyrotropin-Bestimmung","volume":"11","author":"Erdhardt, F.; Marschner, I.; Pickardt, C.R.; Scriba, P.C.","year":"1973","unstructured":"Erdhardt F, Marschner I, Pickardt CR, Scriba PC. Verbesserung und Qualitatskontrolle der radioimmunologischen Thyrotropin-Bestimmung. J Clin Chem Clin Biochem 1973, 11: 381-7.","journal-title":"J Clin Chem Clin Biochem"},{"key":"ref_5","first-page":"223","article-title":"A survey of school children from a severe endemic goitre area in Spain","volume":"198","author":"del Rey F, Escobar; A, Gomez-Pan; MJ, Obregon; J, Mallol; MDR, Arnao; A, Aranda; de Escobar G, Morreale","year":"1981","unstructured":"Escobar del Rey F, Gomez-Pan A, Obregon MJ, Mallol J, Arnao MDR, Aranda A, Morreale de Escobar G. A survey of school children from a severe endemic goitre area in Spain. Q J Med NSL 1981, 198: 223-46.","journal-title":"Q J Med NSL"},{"key":"ref_6","first-page":"571","article-title":"A new principle of thyroxine (T4) and triiodothyronine (T3) radioimmunoassay in unextracted serum using antisera with binding optima at extreme pH ranges","volume":"18","author":"Gartner, R.; Kewenig, M.; Horn, K.; Scriba, P.C.","year":"1980","unstructured":"Gartner R, Kewenig M, Horn K, Scriba PC. A new principle of thyroxine (T4) and triiodothyronine (T3) radioimmunoassay in unextracted serum using antisera with binding optima at extreme pH ranges. J Clin Chem Clin Biochem 1980, 18: 571-7.","journal-title":"J Clin Chem Clin Biochem"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1055\/s-0028-1106482","volume":"100","author":"Habermann, J.; Heinze, H.G.; Horn, K.; Kantlehner, R.; Marschner, I.; Neumann, J.; Scriba, P.C.","year":"1975","unstructured":"Habermann J, Heinze HG, Horn K, Kantlehner R, Marschner I, Neumann J, Scriba PC. Alimentarer Jodmangel in der Bundesrepublik Deutschland. Dtsch med Wschr 1975, 100: 1937-45.","journal-title":"Alimentarer Jodmangel in der Bundesrepublik Deutschland. Dtsch med Wschr"},{"key":"ref_8","first-page":"513","article-title":"Iodized oil in the prevention of endemic goiter and cretinism. In: Endemic goiter and cretinism-iodine nutrition in health and disease JB Stanbury, BS Hetzel","author":"Hetzel, B.S.; Thilly, C.; Fierro-Benitez, R.; Petrell, E.A.; Butterfield, J.H.; Stanbury, J.B.","year":"1980","unstructured":"Hetzel BS, Thilly C, Fierro-Benitez R, Petrell EA, Butterfield JH, Stanbury JB. Iodized oil in the prevention of endemic goiter and cretinism. In: Endemic goiter and cretinism-iodine nutrition in health and disease JB Stanbury, BS Hetzel (eds) New York, Chichester, Brisbane, Toronto: John Wiley 1980, 513-32."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(83)90636-0","article-title":"Iodine deficiency disorders (IDD) and their eradication","volume":"II:","author":"Hetzel, B.S.","year":"1983","unstructured":"Hetzel BS. Iodine deficiency disorders (IDD) and their eradication. 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East Afr Med J 1965, 42: 489-501.","journal-title":"East Afr Med J"},{"key":"ref_12","first-page":"369","article-title":"Technique of endemic goitre surveys. In: Endemic goiter","volume":"44","author":"Perez, C.; Scrimshaw, N.S.; Munoz, J.A.","unstructured":"Perez C, Scrimshaw NS, Munoz JA. Technique of endemic goitre surveys. In: Endemic goiter. Monograph series no. 44 Geneva: World Health Organization; 1960: 369-84.","journal-title":"Monograph series"},{"key":"ref_13","article-title":"Endemic goiter and endemic cretinism-iodine nutrition in health and disease","author":"Stanbury, J.B.; Hetzel, B.S.","year":"1980","unstructured":"Stanbury JB, Hetzel BS. Endemic goiter and endemic cretinism-iodine nutrition in health and disease. 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Methodische Untersuchungen und Vergleich von 7 kommerziellen Kits zur radioimmunologischen Thyrotropin-Bestimmung aus getrocknetem Blutstropfen. J Clin Chem Clin Biochem 1980, 18: 807-16.","journal-title":"J Clin Chem Clin Biochem"},{"issue":"1980","key":"ref_16","first-page":"39","article-title":"The validity of serum TSH measurements by immunoassay","volume":"528","author":"Wood, W.G.; Habermann, J.; Marschner, I.; Scriba, P.C.","unstructured":"Wood WG, Habermann J, Marschner I, Scriba PC. The validity of serum TSH measurements by immunoassay. 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