{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:11:08Z","timestamp":1759731068691,"version":"build-2065373602"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:p>The registry of digestive tract tumours established for the department of Cote-d'Or (France) was used to study the epidemiological characteristics and the natural history of biliary tract cancers. Age standardised incidence rates for gallbladder cancers were 2.7\/100,000 for women and 0.9\/100,000 for men. The corresponding rates for extrahepatic bile duct cancers were 0.5\/100,000 and 1.7\/100,000, and for ampulla of Vater cancer 0.3\/100,000 and 0.3\/100,000. The three cancers differ in their descriptive epidemiology and should be considered separately in epidemiological analytical investigations. The incidence of each of the three diseases increased with age, and cancers of known histological type were mainly adenocarcinomas. Some gallbladder cancers were undifferentiated or squamous cell carcinomas. There was no significant variation in incidence for gallbladder cancer and extrahepatic bile duct cancer over the eight years of the study. The association with gallstones was frequent in gallbladder cancer: 70.5% compared to 13.0% in other biliary tract cancers (less than 0.001). Although the association of gallbladder cancer with gallstones is frequent, few patients with cholelithiasis experience development of a gallbladder cancer. It is necessary to identify among patients with gallstones a subgroup at high risk of gallbladder cancer in whom prophylactic surgery might be justified. Biliary tract cancers are seldom diagnosed early: lymph nodes or visceral metastases were present in 77% of gallbladder cancers, in 83% of extrahepatic bile duct cancers, and in 55% of ampulla of Vater cancers at the time of diagnosis. The corresponding resectability rates were 46.1%, 11.9%, and 38.9%. The five-year overall survival rates were 2.9% for gallbladder cancer, 0% for extrahepatic bile duct cancer, and 18.3% for ampulla of Vater cancer. The corresponding five-year survival rates after surgery for cure were 10.3%, 0%, and 35.7%. Biliary tract cancer still represent a great therapeutic challenge.<\/jats:p>","DOI":"10.1136\/jech.41.4.344","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:09:01Z","timestamp":1226502541000},"page":"344-348","source":"Crossref","is-referenced-by-count":5,"title":["Biliary tract cancers in Cote-d'Or (France): incidence and natural history."],"prefix":"10.1136","volume":"41","author":[{"given":"P","family":"Renard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Boutron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Faivre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Milan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bedenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Klepping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,12,1]]},"reference":[{"key":"ref_1","article-title":"Cancer incidence in five continents, vol IV","volume":"42","author":"Waterhouse, J.; Muir, C.; Correa, P.; Powell, J.","year":"1982","unstructured":"Waterhouse J, Muir C, Correa P, Powell J. Cancer incidence in five continents, vol IV. lARC Scientific Publications, No. 42, Lyon, 1982.","journal-title":"lARC Scientific Publications"},{"key":"ref_2","first-page":"95","article-title":"Incidence of biliary tract cancer in Los Angeles","volume":"62","author":"Menck, H.R.; Mack, T.M.","year":"1982","unstructured":"Menck HR, Mack TM. Incidence of biliary tract cancer in Los Angeles. Natl Cancer Inst Monogr, 1982; 62: 95-9.","journal-title":"Natl Cancer Inst Monogr"},{"key":"ref_3","first-page":"5165","article-title":"International variations in epidemiology of cancers of the extrahepatic biliary tract","volume":"45","author":"Strom, B.L.; Hibberd, P.L.; Soper, K.A.; Stolley, P.D.; Nelson, W.L.","year":"1985","unstructured":"Strom BL, Hibberd PL, Soper KA, Stolley PD, Nelson WL. International variations in epidemiology of cancers of the extrahepatic biliary tract. 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Demonstration of high prevalence and early onset by cholecystography","volume":"283","author":"Sampliner, R.E.; Bennett, P.H.; Comess, L.J.; Rose, F.A.; Burch, T.A.","year":"1970","unstructured":"Sampliner RE, Bennett PH, Comess LJ, Rose FA, Burch TA. Gallbladder disease in Pima indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med 1970; 283: 1358-64.","journal-title":"N Engl J Med"},{"key":"ref_6","first-page":"77","article-title":"Gallstones and risk of gallbladder cancer","volume":"75","year":"1985","unstructured":"Lowenfels AB, Lindstrom CG, Conway MJ, Hastings PR. Gallstones and risk of gallbladder cancer. JNCI 1985; 75: 77-80.","journal-title":"JNCI"},{"key":"ref_7","first-page":"62","article-title":"Silent gallstones: The doctor's dilemma","volume":"8","author":"Diehl, A.K.","year":"1982","unstructured":"Diehl AK. Silent gallstones: The doctor's dilemma. Compr Ther 1982; 8: 62-8.","journal-title":"Compr Ther"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(84)90605-6","article-title":"Gallbladder disease and cholecystectomy rate are independently variable","volume":"ii:","author":"Bateson, M.C.","year":"1984","unstructured":"Bateson MC. Gallbladder disease and cholecystectomy rate are independently variable. Lancet 1984; ii: 621-4.","journal-title":"Lancet"},{"key":"ref_9","first-page":"1029","article-title":"Gallstones and mortality: a study of all gallstone related deaths in a single health district","volume-title":"Gut","volume":"25","author":"Godfrey, P.J.; Bates, T.; Harrison, M.; King, M.B.; Padley, N.R.","year":"1984","unstructured":"Godfrey PJ, Bates T, Harrison M, King MB, Padley NR. Gallstones and mortality: a study of all gallstone related deaths in a single health district. Gut 1984; 25: 1029-33."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1056\/NEJM198209233071305","article-title":"The natural history of silent gallstones. The innocent gallstone is not a myth","volume":"307","author":"Gracie, W.A.; Ransohoff, D.F.","year":"1982","unstructured":"Gracie WA, Ransohoff DF. The natural history of silent gallstones. The innocent gallstone is not a myth. N Engl J Med 1982; 307: 798-800.","journal-title":"N Engl J Med"},{"key":"ref_11","unstructured":"JAMA 1983; 250: G, Maclntyre","article-title":"JAMA 1983; 250"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/1097-0142(19840915)54:6<965::AID-CNCR2820540603>3.0.CO;2-X","article-title":"Cooperative Oncology Group Experience with chemotherapy for inoperable gallbladder and bile duct cancer","volume":"54","year":"1984","unstructured":"Cooperative Oncology Group Experience with chemotherapy for inoperable gallbladder and bile duct cancer. 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Lancet 1977; ii: 500.","journal-title":"Lancet; 185-9) the first of the two references 32 in the text should relate to the following: Weinberg EG"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.41.4.344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:35:56Z","timestamp":1759728956000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.41.4.344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1987,12,1]]},"published-print":{"date-parts":[[1987,12]]}},"alternative-id":["10.1136\/jech.41.4.344"],"URL":"https:\/\/doi.org\/10.1136\/jech.41.4.344","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}