{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:12:04Z","timestamp":1759731124475,"version":"build-2065373602"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Child bearing at an early age and prenatal cytogenetic diagnosis in pregnant women of advanced age, combined with selective abortion, make it possible to avoid the birth of many children with serious chromosomal anomalies. To see how many of such births were still avoidable in Europe, data from 16 regional EUROCAT registers of congenital anomalies in nine EEC countries were analysed. In the period 1979-1982 about 30% of children with unbalanced anomalies of autosomes were born (live- and still-births) to mothers over 35 years of age. This amounts to an estimated 1300 cases yearly in the entire population of the nine countries. The approach shows the possible use of registry data for monitoring effects of avoidance strategies.<\/jats:p>","DOI":"10.1136\/jech.42.3.266","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"266-270","source":"Crossref","is-referenced-by-count":4,"title":["Frequency of births with potentially avoidable serious chromosomal anomalies in EEC countries, 1979-1982."],"prefix":"10.1136","volume":"42","author":[{"given":"L P","family":"Ten Kate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Dolk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Cornel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"De Wals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Te Meerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Lechat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00389450","article-title":"Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy","volume":"70","author":"Hassold, T.; Chiu, D.","year":"1985","unstructured":"Hassold T, Chiu D. 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Trends in utilisation of prenatal cytogenetic diagnosis by New York State residents in 1979 and 1980. Am J Public Health 1983; 73: 198-202.","journal-title":"Am J Public Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/oxfordjournals.bmb.a071848","article-title":"Prenatal chromosome analysis and its impact on the birth incidence of chromosome disorders","volume":"39","author":"Ferguson-Smith, M.A.","year":"1983","unstructured":"Ferguson-Smith MA. Prenatal chromosome analysis and its impact on the birth incidence of chromosome disorders. 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