{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:10:48Z","timestamp":1759839048972,"version":"build-2065373602"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Data from the Glasgow Register of Congenital Malformations were used to investigate the extent of the recent decline in the prevalence of anencephaly and spina bifida, and the contribution of antenatal screening to it. Over the period 1974-85 inclusive, 303 pregnancies with an anencephalic foetus were diagnosed, representing an \"adjusted\" prevalence of 1.9 per 1000 total births, of which 179 (59%) were terminated following antenatal screening. There were 364 pregnancies with a spina bifida foetus representing an \"adjusted\" prevalence of 2.3 per 1000 total births, of which 84 (23%) were terminated. Over the study period, the \"adjusted\" prevalence of anencephaly fell by 50% while the birth prevalence fell by 89%; the \"adjusted\" prevalence of spina bifida fell by 38% while the birth prevalence fell by 76%. It was concluded that although the birth prevalence of both defects (particularly anencephaly) would have declined substantially in the absence of screening, the West of Scotland programme should continue.<\/jats:p>","DOI":"10.1136\/jech.42.3.271","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"271-273","source":"Crossref","is-referenced-by-count":17,"title":["Screening for congenital neural tube defects in a high-risk area: an epidemiological perspective."],"prefix":"10.1136","volume":"42","author":[{"given":"D H","family":"Stone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Smalls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Womersley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"article-title":"l Office of Population Censuses and Surveys. Congenital malformation statistics, 1971-80","year":"1983","key":"ref_1","unstructured":"l Office of Population Censuses and Surveys. Congenital malformation statistics, 1971-80. London: HMSO, 1983."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1136\/bmj.289.6453.1182","article-title":"Spina bifida and anencephaly in Scotland","volume":"289","author":"Carstairs, V.; Cole, S.","year":"1984","unstructured":"Carstairs V, Cole S. Spina bifida and anencephaly in Scotland. Br Med J 1984; 289: 1182-4.","journal-title":"Br Med J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/oxfordjournals.bmb.a071849","article-title":"The reduction of anencephalic and spina bifida births by maternal serum alphafetoprotein screening","volume":"39","author":"Ferguson-Smith, M.A.","year":"1983","unstructured":"Ferguson-Smith MA. The reduction of anencephalic and spina bifida births by maternal serum alphafetoprotein screening. Br Med Bull 1983; 39: 365-72.","journal-title":"Br Med Bull"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/adc.60.11.1086","article-title":"Spina bifida-a vanishing nightmare?","volume":"60","author":"Lorber, J.; Ward, A.M.","year":"1985","unstructured":"Lorber J, Ward AM. Spina bifida-a vanishing nightmare? Arch Dis Child 1985; 60: 1086-91.","journal-title":"Arch Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/bmj.290.6464.293","article-title":"Can we afford screening for neural tube defects? The South Wales experience","volume":"290","author":"Hibbard, B.M.; Roberts, C.J.; Elder, G.H.; Evans, K.T.; Laurence, K.M.","year":"1985","unstructured":"Hibbard BM, Roberts CJ, Elder GH, Evans KT, Laurence KM. Can we afford screening for neural tube defects? The South Wales experience. Br MedJ 1985; 290: 293-5.","journal-title":"Br MedJ"},{"article-title":"Acceptedfor publication","year":"1988","key":"ref_6","unstructured":"Acceptedfor publication April 1988"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.42.3.271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:44:51Z","timestamp":1759837491000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.42.3.271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1988,9,1]]},"published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1136\/jech.42.3.271"],"URL":"https:\/\/doi.org\/10.1136\/jech.42.3.271","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}