{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:24:41Z","timestamp":1762079081105,"version":"build-2065373602"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>STUDY OBJECTIVE--The aim was to estimate the age and sex specific incidences of duodenal and gastric ulcers censored for death and migration. DESIGN--A population based cohort was followed seven years through records of x ray examinations, endoscopies, and operations in the only hospital serving the area. SETTING--The study was conducted in the municipality of Troms\u00f8, Northern Norway, where all men aged 20 to 54 years and women aged 20 to 49 years in 1980, a total of 21,440, were included. MAIN RESULTS--We found an incidence of 1.47 (95% CI 1.21-1.76) and 0.88 (0.67-1.14) per 1000 person-years for gastric and 1.98 (1.69-2.31) and 0.85 (0.64-1.11) for duodenal ulcers in men and women, respectively. A small and insignificant sex difference for gastric ulcer was noted. The duodenal preponderance in men was only recognised among the ulcers identified by x ray, not among ulcers diagnosed by endoscopy. CONCLUSIONS--This population based study has, in contrast to recent studies from other areas, revealed an unchanged high incidence of gastric and duodenal ulcer in both sexes. Compared to earlier studies from this area it indicates a preponderance of duodenal ulcers. The study also shows the impact of attendance rate, death, and migration, and of diagnostic methods on the incidence estimates. Ignoring these potential biases may lead to conclusions on peptic ulcer trends that reflect artefacts rather than real changes in peptic ulcer occurrence.<\/jats:p>","DOI":"10.1136\/jech.46.4.433","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"433-436","source":"Crossref","is-referenced-by-count":10,"title":["Changing incidence of peptic ulcer--facts or artefacts? A cohort study from Troms\u00f8."],"prefix":"10.1136","volume":"46","author":[{"given":"R","family":"Johnsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Straume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O H","family":"F\u00f8rde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Burhol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"ref_1","first-page":"219","article-title":"Changing patterns in the epidemiology of peptic ulcer","volume":"2","author":"Langman, M.J.S.","year":"1973","unstructured":"Langman MJS. Changing patterns in the epidemiology of peptic ulcer. Am J Gastroenterol 1973; 2: 219-26.","journal-title":"Am J Gastroenterol"},{"key":"ref_2","first-page":"115","article-title":"Civilisation and peptic ulcer","volume":"i:","author":"Susser, M.; Stein, Z.","year":"1962","unstructured":"Susser M, Stein Z. Civilisation and peptic ulcer. Lancet 1962; i: 115-9.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00365528509095826","article-title":"Geographic and temporal variations in the occurrence of peptic ulcer disease","volume":"110","author":"Sonnenberg, A.","year":"1985","unstructured":"Sonnenberg A. Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol 1985; 20 (suppl 110): 11-24.","journal-title":"Scand J Gastroenterol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.0954-6820.1943.tb10025.x","article-title":"Gastric and duodenal ulcer","volume":"116","author":"Ihre, B.J.E.; Muller, R.","year":"1943","unstructured":"Ihre BJE, Muller R. Gastric and duodenal ulcer. Acta Med Scand 1943; 116: 33-55.","journal-title":"Acta Med Scand"},{"key":"ref_5","first-page":"280","article-title":"Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970","volume-title":"to 1978. Gastroenterology 1980","volume":"78","author":"Elashoff, J.D.; Grossman, M.I.","unstructured":"Elashoff JD, Grossman MI. Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970 to 1978. Gastroenterology 1980; 78: 280-5."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2105\/AJPH.73.9.1066","article-title":"A reappraisal of time trends in ulcer disease: factors related to changes in ulcer hospitalization and mortality rates","volume":"73","author":"Kurata, J.H.; Elashoff, J.D.; Haile, B.M.; Honda, G.D.","year":"1983","unstructured":"Kurata JH, Elashoff JD, Haile BM, Honda GD. A reappraisal of time trends in ulcer disease: factors related to changes in ulcer hospitalization and mortality rates. Am J Public Health 1983; 73: 1066-72.","journal-title":"Am J Public Health"},{"key":"ref_7","first-page":"489","article-title":"Rising frequency of ulcer perforation in elderly people in the United Kingdom","volume":"i:","author":"Walt, R.; Katschinski, B.; Logan, R.; Ashley, J.; Langman, M.","year":"1986","unstructured":"Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1986; i: 489-92.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0021-9681(82)90027-3","article-title":"Period effects, generation effects and age effects in peptic ulcer mortality","volume":"35","author":"Susser, M.","year":"1982","unstructured":"Susser M. Period effects, generation effects and age effects in peptic ulcer mortality. J Chron Dis 1982; 35: 29-40.","journal-title":"J Chron Dis"},{"key":"ref_9","first-page":"35","article-title":"Hospital admissions for peptic ulcer during 1958-72","volume":"i:","author":"Brown, R.C.; Langman, M.J.S.; Lambert, P.M.","year":"1976","unstructured":"Brown RC, Langman MJS, Lambert PM. Hospital admissions for peptic ulcer during 1958-72. BMJ 1976; i: 35-7.","journal-title":"BMJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(81)92470-3","article-title":"years of hospital admisions for peptic ulcer in England and Wales","volume":"i:","author":"Coggon, D.; Lambert, P.; Langman, M.J.S.","year":"1981","unstructured":"Coggon D, Lambert P, Langman MJS. 20 years of hospital admisions for peptic ulcer in England and Wales. Lancet 1981; i: 1302-4.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01296680","article-title":"Changes in physician visits for gastric and duodenal ulcer in the United States during 1958-1984 as shown by National Disease and Threpeutic Index (NDTI)","volume":"32","author":"Sonnenberg, A.","year":"1987","unstructured":"Sonnenberg A. Changes in physician visits for gastric and duodenal ulcer in the United States during 1958-1984 as shown by National Disease and Threpeutic Index (NDTI). Dig Dis Sci 1987; 32: 1-7.","journal-title":"Dig Dis Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2105\/AJPH.75.6.625","article-title":"The incidence of duodenal and gastric ulcers in a large health maintenance organization","volume":"75","author":"Kurata, J.H.; Honds, G.D.; Frankl, H.","year":"1985","unstructured":"Kurata JH, Honds GD, Frankl H. The incidence of duodenal and gastric ulcers in a large health maintenance organization. Am J Public Health 1985; 75: 625-9.","journal-title":"Am J Public Health"},{"key":"ref_13","first-page":"131","article-title":"Peptic ulcer in town and country","volume":"13","author":"Pulvertaft, C.N.","year":"1959","unstructured":"Pulvertaft CN. Peptic ulcer in town and country. Br J Prev Soc Med 1959; 13: 131-8.","journal-title":"Br J Prev Soc Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/00365521.1975.12096983","article-title":"The incidence of duodenal ulcer in Copenhagen county","volume":"10","author":"0, Bonnevie","year":"1975","unstructured":"Bonnevie 0. The incidence of duodenal ulcer in Copenhagen county. Scand J Gastoentorol 1975; 10: 385-93.","journal-title":"Scand J Gastoentorol"},{"key":"ref_15","first-page":"231","article-title":"The incidence of gastric ulcer in Copenhagen county. Scand J3 Gastroenterol","volume":"10","author":"0, Bonnevie","year":"1975","unstructured":"Bonnevie 0. The incidence of gastric ulcer in Copenhagen county. Scand J3 Gastroenterol 1975; 10: 231-9."},{"issue":"30","key":"ref_16","first-page":"1063","article-title":"Localization of peptic ulcus in a series of cases from Troms and Troms0 hospital, Norway","volume":"1945","author":"Poppe, E.","unstructured":"Poppe E. Localization of peptic ulcus in a series of cases from Troms and Troms0 hospital, Norway. Tids Norsk Lcegeforen 1945: 30: 1063-5.","journal-title":"Tids Norsk Lcegeforen"},{"issue":"115","key":"ref_17","article-title":"The behaviour of gastric and duodenal ulcer","volume":"94","author":"Schanke, K.","year":"1946","unstructured":"Schanke K. The behaviour of gastric and duodenal ulcer. Acta Chir Scand 1946; 94 (suppl 115).","journal-title":"Acta Chir Scand"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/oxfordjournals.aje.a112278","article-title":"Epidemiology of peptic ulcer. Report of a conference","volume":"104","author":"Sturdevant, R.A.L.","year":"1976","unstructured":"Sturdevant RAL. Epidemiology of peptic ulcer. Report of a conference. Am J Epidemiol 1976; 104: 9-14.","journal-title":"Am J Epidemiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM198306163082405","article-title":"The Tromso heart study: does coffee raise serum cholesterol?","volume":"303","author":"Thelle, D.S.; Arnesen, E.; Forde, O.H.","year":"1983","unstructured":"Thelle DS, Arnesen E, Forde OH. The Tromso heart study: does coffee raise serum cholesterol? N Engl J Med 1983; 303: 1454-7.","journal-title":"N Engl J Med"},{"key":"ref_20","article-title":"SUGI supplemental library user's guide","author":"SAS Institutes Inc","year":"1986","unstructured":"SAS Institutes Inc. SUGI supplemental library user's guide. 5th ed. Cary, NC: SAS Institute Inc, 1986.","edition":"5th ed"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0140-6736(81)92471-5","article-title":"Surgical treatment of peptic ulcer in the United States","volume":"i:","author":"Fineberg, H.V.; Pearlman, L.A.","year":"1981","unstructured":"Fineberg HV, Pearlman LA. Surgical treatment of peptic ulcer in the United States. Lancet 1981; i: 1305-7.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/gut.31.9.989","article-title":"Towards a true prevalence of peptic ulcer: the Sorreisa gastrointestinal study","volume":"31","author":"Bernersen, B.; Johnsen, R.; Straume, B.; Burhol, P.G.; Jenssen, T.G.; Stakkevold, P.A.","year":"1990","unstructured":"Bernersen B, Johnsen R, Straume B, Burhol PG, Jenssen TG, Stakkevold PA. Towards a true prevalence of peptic ulcer: the Sorreisa gastrointestinal study. Gut 1990; 31: 989-92.","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"538","DOI":"10.7326\/0003-4819-101-4-538","article-title":"Double-contrast barium meal and upper gastrointestinal endoscopy","volume":"101","author":"Dooley, C.P.; Larson, A.W.; Stace, N.H.","year":"1984","unstructured":"Dooley CP, Larson AW, Stace NH, et al. Double-contrast barium meal and upper gastrointestinal endoscopy. Ann Intern Med 1984; 101: 538-45.","journal-title":"Ann Intern Med"},{"key":"ref_24","first-page":"857","article-title":"Changing pattern of duodenal ulcer?","volume":"ii:","author":"Schache, D.J.; Fl, Tovey; Masters, A.; Stebbing, A.; Rees, M.","year":"1987","unstructured":"Schache DJ, Tovey Fl, Masters A, Stebbing A, Rees M. Changing pattern of duodenal ulcer? Lancet 1987; ii: 857.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.0954-6820.1965.tb04323.x","article-title":"Pseudo-ulcer and true peptic ulcer. A clinical, radiographic and statistical follow-up study","volume":"178","author":"Krag, E.","year":"1965","unstructured":"Krag E. Pseudo-ulcer and true peptic ulcer. A clinical, radiographic and statistical follow-up study. Acta Med Scand 1965; 178: 713-28.","journal-title":"Acta Med Scand"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.46.4.433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:07:15Z","timestamp":1759514835000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.46.4.433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1992,8,1]]},"published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1136\/jech.46.4.433"],"URL":"https:\/\/doi.org\/10.1136\/jech.46.4.433","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}