{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:49:26Z","timestamp":1761252566125,"version":"build-2065373602"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>STUDY OBJECTIVE--The aim was to determine the loss of quality of life following admission to hospital with suspected myocardial infarction. DESIGN--The study involved a cohort of admissions, with interview and follow up for 100 days. Main outcome measures were the quality of life prior to admission and at each stage of convalescence, estimated using the Rosser-Kind matrix: the calculated number of quality adjusted days during a 100 d follow up period. SETTING--The study took place in a teaching hospital in Scotland. PATIENTS--206 patients were admitted with suspected acute myocardial infarction. Infarction was confirmed in 160 (Q wave infarcts 100, non-Q-wave infarcts 60), and unconfirmed in 46. MAIN RESULTS--The quality of life scores before the suspected heart attack were similar for patients whose final diagnosis was Q wave infarction, non-Q-wave infarction, or non-infarction. Of the 160 patients with confirmed infarction, only 54 (34%) had regained their previous quality of life scores at the end of 100 days, compared with 26 of 46 (57%) patients with unconfirmed infarction (p &lt; 0.01). The mean numbers of quality adjusted days lost to patients with Q wave infarction, non-Q-wave infarction, and non-infarction were 17.0, 12.4, and 5.9 respectively (infarction v non-infarction, p &lt; 0.0001). Measurements of both quantity and quality of life contributed to these results. CONCLUSIONS--The number of quality adjusted days lost after acute myocardial infarction is a practicable measurement that is relevant to patients' lives. It might be suitable as an outcome measure for clinical trials of thrombolytic therapy.<\/jats:p>","DOI":"10.1136\/jech.46.6.612","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"612-616","source":"Crossref","is-referenced-by-count":14,"title":["Quality of life in the first 100 days after suspected acute myocardial infarction--a suitable trial endpoint?"],"prefix":"10.1136","volume":"46","author":[{"given":"J","family":"Rawles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Light","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"article-title":"Measurement of left ventricular function as an endpoint in trials of thrombolytic therapy. Coronary Artery non-Q-wave infarction, and least for those with Dis 1990; 1: 13-22. non-infarction. Those who died lost the greatest","author":"Sheehan, F.H.","key":"ref_1","unstructured":"Sheehan FH. Measurement of left ventricular function as an endpoint in trials of thrombolytic therapy. Coronary Artery non-Q-wave infarction, and least for those with Dis 1990; 1: 13-22. non-infarction. Those who died lost the greatest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.CIR.76.1.142","article-title":"Thrombolysis in myocardial infarction (TIMI) trial, phase I: a number of quality adjusted days, while those who comparison between intravenous tissue plasminogen lived lost more quality adjusted days if infarction activator and intravenous streptokinase","volume":"76","author":"Chesebro, J.H.; Knatterud, G.; Roberts, R.","year":"1987","unstructured":"Chesebro JH, Knatterud G, Roberts R, et al. 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A scale of valuations of states of illness: is there a social consensus?","volume":"7","author":"Rosser, R.","year":"1978","unstructured":"Rosser R, Kind P. A scale of valuations of states of illness: is there a social consensus? Int J Epidemiol 1978; 7: 347-58.","journal-title":"Int J Epidemiol"},{"key":"ref_5","first-page":"361","article-title":"The measurement of hospital very sensitive to small differences in the quality of output","volume":"1","author":"Rosser, R.M.; Watts, V.C.","year":"1972","unstructured":"Rosser RM, Watts VC. The measurement of hospital very sensitive to small differences in the quality of output. Int Epidemiol 1972; 1: 361-8.","journal-title":"Int Epidemiol"},{"key":"ref_6","first-page":"359","article-title":"Classification of disability and distress by ward life, or that any physiological differences between nurses: a reliability study","volume-title":"Int3rEpidemiol","volume":"7","author":"Benson, T.J.R.","year":"1978","unstructured":"Benson TJR. Classification of disability and distress by ward life, or that any physiological differences between nurses: a reliability study. Int3rEpidemiol 1978; 7: 359-61."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/bmj.291.6491.326","article-title":"Economics of coronary artery bypass grafting","volume":"291","author":"Williams, A.","year":"1985","unstructured":"Williams A. Economics of coronary artery bypass grafting. BMJ 1985; 291: 326-9.","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(87)91685-0","article-title":"Qualms about QALYs","volume":"i:","author":"Smith, A.","year":"1987","unstructured":"Smith A. Qualms about QALYs. Lancet 1987; i: 1134-6.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/01.CIR.64.6.1227","article-title":"Comparative reproducibility and validity of systems for previously. assessing cardiovascular functional class: advantages of a Our results suggest that the theoretical benefits new specific activity scale","volume":"64","author":"Goldman, L.; Hashimoto, B.; Cook, E.F.; Loscalzo, A.","year":"1981","unstructured":"Goldman L, Hashimoto B, Cook EF, Loscalzo A. Comparative reproducibility and validity of systems for previously. assessing cardiovascular functional class: advantages of a Our results suggest that the theoretical benefits new specific activity scale. Circulation 1981; 64: 1227-34.","journal-title":"Circulation"},{"key":"ref_10","first-page":"751","article-title":"The ofa non-Q-Wave rather than a Q wave infarct may measurement of dyspnoea. Contents, interobserver not result in improved quality of life. 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Jf Med Ethics 1989; 15: 143-7.","journal-title":"Jf Med Ethics"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.46.6.612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T14:42:32Z","timestamp":1759502552000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.46.6.612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1992,12,1]]},"published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1136\/jech.46.6.612"],"URL":"https:\/\/doi.org\/10.1136\/jech.46.6.612","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}