{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:03:35Z","timestamp":1785881015074,"version":"3.56.0"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>STUDY OBJECTIVE AND DESIGN--In Aalsmeer, a horticultural community near the main international airport in The Netherlands, a more than fourfold increase in the incidence of haematopoietic malignancies in young people was observed between 1980 and 1985. In a population based case-control study, the association with local environmental factors was investigated. PARTICIPANTS--For each patient younger than 40 years of age (n = 14) diagnosed between 1975 and 1989, four age and sex matched controls were selected via local general practitioners. METHODS--All parents of patients and controls completed a questionnaire on their lifestyle, living conditions, and health, for several years preceding each individual diagnosis. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, matched, and, if necessary, stratified for neighbourhood. MAIN RESULTS--Increased ORs were recorded for intensive use of petroleum products and pesticides by the patients themselves and their fathers: OR petroleum products: 8.0 (95% CI 2.2, 129.9) and 9.0 (1.0, 66.1) respectively; OR pesticides: 6.0 (0.6, 49.3) and 3.2 (1.0, 10.1) respectively. Swimming in a local pond was also significantly associated with the disease: OR = 5.3 (1.3, 17.4). In the 1970s this pond had been polluted by petroleum products and pesticides. CONCLUSIONS--The increased incidence of childhood haematopoietic malignancies in Aalsmeer may have been associated with several specific local environmental factors. Interpretation of the results, however, should take into account the fact that confidence intervals were wide because of the limited number of cases.<\/jats:p>","DOI":"10.1136\/jech.48.2.161","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"161-165","source":"Crossref","is-referenced-by-count":24,"title":["Case-control study on the association between a cluster of childhood haematopoietic malignancies and local environmental factors in Aalsmeer, The Netherlands."],"prefix":"10.1136","volume":"48","author":[{"given":"Y M","family":"Mulder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Drijver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I A","family":"Kreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"key":"ref_1","article-title":"The leukemias: epidemiologic aspects. Monographs in epidemiology and biostatistics","volume-title":"Volume 6","author":"Linet, M.S.","year":"1985","unstructured":"Linet MS. The leukemias: epidemiologic aspects. Monographs in epidemiology and biostatistics. Volume 6. Oxford: Oxford University Press, 1985."},{"key":"ref_2","first-page":"307","article-title":"Review of reported increases of childhood cancer rates in the vicinity of nuclear installations in the UK","volume":"152","author":"Gardner, M.J.","year":"1989","unstructured":"Gardner MJ. Review of reported increases of childhood cancer rates in the vicinity of nuclear installations in the UK. 7 Stat Soc (A) 1989;152:307-25."},{"key":"ref_3","first-page":"201","article-title":"Childhood leukemia in Woburn, Massachusetts","volume":"101","author":"Cutler, J.J.; Parker, G.S.; Rosen, S.; Prenney, B.; Healey, R.; Caldwell, G.G.","year":"1986","unstructured":"Cutler JJ, Parker GS, Rosen S, Prenney B, Healey R, Caldwell GG. Childhood leukemia in Woburn, Massachusetts. Public Health Reports 1986;101:201-5.","journal-title":"Public Health Reports"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01621459.1986.10478307","article-title":"An analysis of contaminated well water and health effects in Woburn, Massachusetts","volume":"81","author":"Lagakos, S.W.; Wessen, B.J.; Zelen, M.","year":"1986","unstructured":"Lagakos SW, Wessen BJ, Zelen M. An analysis of contaminated well water and health effects in Woburn, Massachusetts. J Am Stat Assoc 1986;81:583-614.","journal-title":"J Am Stat Assoc"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.5271\/sjweh.1848","article-title":"Association of childhood cancer with residential traffic density","volume":"15","author":"Savitz, D.A.; Feingold, L.","year":"1989","unstructured":"Savitz DA, Feingold L. Association of childhood cancer with residential traffic density. Scandinavian Journal of Work and Environmental Health 1989;15:360-3.","journal-title":"Scandinavian Journal of Work and Environmental Health"},{"key":"ref_6","article-title":"Leefgewoonten, gezondheid en woonomgeving. Een milieu-epidemiologisch onderzoek naar de relatie tussen omgevingsfactoren en kanker bi] jongeren in de gemeente Aalsmeer. (In Dutch)","author":"Mulder, Y.M.; Drijver, M.","year":"1989","unstructured":"Mulder YM, Drijver M. Leefgewoonten, gezondheid en woonomgeving. Een milieu-epidemiologisch onderzoek naar de relatie tussen omgevingsfactoren en kanker bi] jongeren in de gemeente Aalsmeer. (In Dutch). Amstelveen: Basisgezondheidsdienst Amstelland De Meerlanden, 1989."},{"key":"ref_7","article-title":"Incidence and prognosis of cancer in The Netherlands: studies based on cancer registries","author":"Coebergh, J.W.W.","year":"1991","unstructured":"Coebergh JWW. Incidence and prognosis of cancer in The Netherlands: studies based on cancer registries. Rotterdam: Erasmus Universiteit, 1991. (Thesis)."},{"key":"ref_8","first-page":"22","article-title":"Statistical methods in cancer research: I. The analysis of case-control studies","author":"Breslow, N.E.; Day, N.E.","year":"1981","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research: I. The analysis of case-control studies. Lyon: IARC\/WHO, 1981:22-159."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/oxfordjournals.aje.a121617","article-title":"Proportion of disease caused or prevented by a given exposure, trait or intervention","volume":"99","author":"Miettinen, O.S.","year":"1974","unstructured":"Miettinen OS. Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol 1974;99:325-32.","journal-title":"Am J Epidemiol"},{"key":"ref_10","first-page":"284","article-title":"Compendium gezondheidsstatistiek Nederland 1986. (In Dutch). 's-Gravenhage","volume":"1986","author":"voor de Statistiek, Centraal Bureau; van WVC, Ministerie","unstructured":"Centraal Bureau voor de Statistiek, Ministerie van WVC. Compendium gezondheidsstatistiek Nederland 1986. (In Dutch). 's-Gravenhage: Staatsuitgeverij, 1986:284-5.","journal-title":"Staatsuitgeverij"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0140-6736(90)93389-7","article-title":"Evidence from population mixing in British new towns 1946-85 of an infective basis for childhood leukaemia","volume":"336","author":"Kinlen, L.J.; Clarke, K.; Hudson, C.","year":"1990","unstructured":"Kinlen LJ, Clarke K, Hudson C. Evidence from population mixing in British new towns 1946-85 of an infective basis for childhood leukaemia. Lancet 1990;336:577-82.","journal-title":"Lancet"},{"key":"ref_12","first-page":"82","article-title":"Childhood leukemia in the Netherlands; a register based epidemiologic study","author":"van, Steensel-Moll H.A.","year":"1983","unstructured":"Steensel-Moll HA van. Childhood leukemia in the Netherlands; a register based epidemiologic study. Rotterdam: Erasmus Universiteit, 1983:82-97,98-116."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5271\/sjweh.1861","article-title":"Cancer risk in a cohort of licensed pesticide users","volume":"15","author":"Corrao, G.","year":"1989","unstructured":"Corrao G. Cancer risk in a cohort of licensed pesticide users. Scandinavian Journal of Environmental Health 1989;15:203-9.","journal-title":"Scandinavian Journal of Environmental Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ajim.4700180310","article-title":"Environmental epidemiology of nonHodgkin's lymphoma in eastern Nebraska","volume":"18","author":"Weisenburger, D.","year":"1990","unstructured":"Weisenburger D. Environmental epidemiology of nonHodgkin's lymphoma in eastern Nebraska. American Journal of Industrial Medicine 1990;18:303-5.","journal-title":"American Journal of Industrial Medicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/1097-0142(19910415)67:8<2211::AID-CNCR2820670835>3.0.CO;2-4","article-title":"Exposure histories in acute nonlymphocytic leukemia patients with prior preleukemic condition","volume":"67","author":"Crane, M.M.; Keating, M.J.","year":"1991","unstructured":"Crane MM, Keating MJ. Exposure histories in acute nonlymphocytic leukemia patients with prior preleukemic condition. Cancer 1991;67:2211-4.","journal-title":"Cancer"},{"key":"ref_16","first-page":"105","article-title":"Bestrijdingsmiddelen en oppervlaktewaterkwaliteit; een inventarisatie van hetgebruik van bestrijdingsmiddelen in de akkerbouw en tuinbouw. (In Dutch)","author":"Berends, A.G.","year":"1988","unstructured":"Berends, AG. Bestrijdingsmiddelen en oppervlaktewaterkwaliteit; een inventarisatie van hetgebruik van bestrijdingsmiddelen in de akkerbouw en tuinbouw. (In Dutch). Lelystad: RIZA, 1988:105-6."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/bmj.302.6778.687","article-title":"Case-control study of leukaemia and non-Hodgkin's lymphoma in children in Caithness near the Dounreay nuclear installation","volume":"302","author":"Urquhart, J.D.; Black, R.J.; Muirhead, M.J.; Sharp, L.; Maxwell, M.; Eden, O.B.; Jones, D.A.","year":"1991","unstructured":"Urquhart JD, Black RJ, Muirhead MJ, Sharp L, Maxwell M, Eden OB, Jones DA. Case-control study of leukaemia and non-Hodgkin's lymphoma in children in Caithness near the Dounreay nuclear installation. BMJ 1991;302:687-92.","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/oxfordjournals.aje.a115790","article-title":"A sobering start for the cluster buster's conference","volume":"132","author":"Rothman, K.J.","year":"1990","unstructured":"Rothman KJ. A sobering start for the cluster buster's conference. Am J Epidemiol 1990;132(Suppl):S6-13.","journal-title":"Am J Epidemiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.aje.a115621","article-title":"Counterpoint from a cluster buster","volume":"132","author":"Neutra, R.R.","year":"1990","unstructured":"Neutra RR. Counterpoint from a cluster buster. 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