{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:07:29Z","timestamp":1759838849615,"version":"build-2065373602"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>STUDY OBJECTIVES--The study aimed to develop and evaluate a method for small area analysis of different non-random components of the variation in death rates. The method was applied to incidence and mortality data for selected malignant neoplasms in 26 administrative health areas in Sweden. DESIGN--Variation in mortality and incidence rates for malignant neoplasms of the trachea, bronchus, and lung; colon; rectum; and cervix uteri in the 26 health areas were analysed after standardisation for age. In addition, the systematic and random components of variance were estimated. The systematic component of variance in mortality was divided into two additive components-one component was dependent on the variation in the corresponding incidence rates and the other remained after adjustment for incidence. SETTING AND PARTICIPANT--All cases diagnosed between 1972 and 1983 and all deaths between 1974 and 1985 for selected malignant neoplasms in Swedish citizens and other residents in Sweden, aged between 0 and 64 years, were analysed. MAIN RESULTS--Much of the observed variation in mortality was explained by the estimated random variation. For malignant neoplasms of the trachea, bronchus, and lung the systematic variation in mortality was mainly explained by the variation in incidence. For cancer of the cervix uteri, alone, there was significant systematic variation of moderate magnitude that was not explained by the incidence rates. CONCLUSIONS--These methods made it possible to divide the observed variance in mortality into different components. Random effects and variance in incidence rates were found to be of great importance when analysing the variance in death rates between health areas. By studying different systematic components of variation it is possible to identify fields for in depth studies on the quality of prevention and treatment.<\/jats:p>","DOI":"10.1136\/jech.49.2.214","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"214-221","source":"Crossref","is-referenced-by-count":10,"title":["Components of small area variation in death rates: a method applied to data from Sweden."],"prefix":"10.1136","volume":"49","author":[{"given":"R","family":"Westerling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","first-page":"293","article-title":"Guidelines for regional mortality analysis: an epidemiological approach to health planning","volume":"14","author":"Rosen, M.; Nystrom, L.; Wall, S.","year":"1986","unstructured":"Rosen M, Nystrom L, Wall S. 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Problems in the interpretation of small area analysis of epidemiological data: the case of cancer incidence in"},{"key":"ref_5","first-page":"408","article-title":"Area variation in mortality from diseases amenable to medical intervention: the contribution of differences in morbidity","volume":"15","author":"Bauer, R.L.; Charlton, J.R.H.","year":"1986","unstructured":"Bauer RL, Charlton JRH. Area variation in mortality from diseases amenable to medical intervention: the contribution of differences in morbidity. Int7Epidemiol 1986; 15:408-12.","journal-title":"Int7Epidemiol"},{"key":"ref_6","article-title":"Community atlas of avoidable death","volume":"3","author":"WWEuropean, Holland","year":"1988","unstructured":"Holland WW, ed. European Community atlas of avoidable death. Oxford: Oxford Medical Publications, 1988. Commission of the European Communities Health Services Research Series no. 3.","journal-title":"Commission of the European Communities Health Services Research Series"},{"key":"ref_7","article-title":"Community atlas of avoidable death","volume-title":"Commission of the European Communities Health Services Research Series No 6","author":"WWEuropean, Holland","year":"1991","unstructured":"Holland WW, ed. European Community atlas of avoidable death. 2nd ed Vol 1. Oxford: Oxford Medical Publications, 1991. Commission of the European Communities Health Services Research Series No 6.","edition":"2nd ed Vol 1"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1056\/NEJM197603112941104","article-title":"Measuring the quality of medical care","volume":"294","author":"Ruttstein, D.D.; Berenberger, W.; Chalmers, T.C.; Child, G.C.; Fischmen, A.P.; Perrin, E.B.","year":"1976","unstructured":"Ruttstein DD, Berenberger W, Chalmers TC, Child GC, Fischmen AP, Perrin EB. 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Quality Assurance in Health Care 1992;4:319-28.","journal-title":"Health Care"},{"key":"ref_12","unstructured":"Survival of cancer patients. Cases diagnosed in Norway 1968-","article-title":"Survival of cancer patients. Cases diagnosed in Norway 1968-"},{"key":"ref_13","article-title":"Cancer registration in Sweden. Studies on completeness and validity of incidence and mortality registers","author":"Mattson, B.","year":"1984","unstructured":"Mattson B. Cancer registration in Sweden. Studies on completeness and validity of incidence and mortality registers. University of Stockholm, 1984.Thesis."},{"key":"ref_14","article-title":"forebyggande mm","volume-title":"prevention etc. Report from the Swedish Cancer Committe, In Swedish","author":"av cancerkommitten. Cancer, Betankande; orsaker","year":"causes,","unstructured":"Betankande av cancerkommitten. Cancer, orsaker, forebyggande mm. Stockholm: SOU 1984:67. 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