{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:35:46Z","timestamp":1773866146961,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>STUDY OBJECTIVE: To analyse risk factors for seromucinous benign ovarian cysts. DESIGN: Between 1984 and 1994 a case-control study was carried out. Cases were 225 women aged less than 65 year with a histologically confirmed diagnosis of benign seromucinous ovarian cysts admitted to a network of obstetrics and gynaecology departments in Milan. Controls were a random sample of 450 women admitted for acute conditions that were not gynaecological, hormonal or neoplastic. They were interviewed within the framework of a case-control study of female genital neoplasms. SETTING: Network of hospitals in the greater Milan area, Italy. MAIN RESULTS: The risk of seromucinous benign ovarian cysts was higher in more educated women than in women with fewer than seven years of schooling. The odds ratios (OR) for seromucinous ovarian cysts were 1.3 and 1.4 respectively in women reporting 7-11 and &gt; or = 12 years of schooling, and the trend in risk was statistically significant (chi(2)1 trend 5.20, p &lt; 0.05). There was no clear relationship between the risk of seromucinous ovarian cysts and marital status, age at first marriage, oral contraceptive use, smoking or body mass index. In comparison with women reporting menstrual cycles lasting &lt; 28 days, the risks of seromucinous cysts were 1.6, 2.6, and 2.5 respectively in women reporting cycles lasting 28-30, &gt; or = 31 days, or with totally irregular ones. Among ever married women, nine cases and two controls reported difficulty in conception, and the corresponding OR for seromucinous cysts was 17.7 (95% confidence interval 4.2, 83.8). CONCLUSIONS: The risk of seromucinous benign ovarian tumours is greater in more educated women and in women with a history of infertility and with long or irregular menstrual cycles.<\/jats:p>","DOI":"10.1136\/jech.51.4.449","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T15:10:54Z","timestamp":1226502654000},"page":"449-452","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors for seromucinous benign ovarian cysts in northern Italy."],"prefix":"10.1136","volume":"51","author":[{"given":"F","family":"Parazzini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Negri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Mezzopane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Crosignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1471-0528.1992.tb13733.x","article-title":"Benign ovarians cysts in England and Wales and in the United States","volume":"99","author":"Westhoff, C.; Clark, C.J.G.","year":"1992","unstructured":"Westhoff C, Clark CJG. 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Epidemiol Community Health 1992;46:528-3 1.","journal-title":"Epidemiol Community Health"},{"key":"ref_5","first-page":"594","article-title":"Oral contraceptive use and the risk of ovarian cancer: an Italian case-control study","volume":"28","author":"Parazzini, F.; La Vecchia, C.; Negri, E.; Bocciolone, L.; Fedele, L.; Franceschi, S.","year":"1991","unstructured":"Parazzini F, La Vecchia C, Negri E, Bocciolone L, Fedele L, Franceschi S. Oral contraceptive use and the risk of ovarian cancer: an Italian case-control study. EurJ7 Cancer 1991;28:594-8.","journal-title":"EurJ7 Cancer"},{"key":"ref_6","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel, N.; Haenszel, W.S.","year":"1959","unstructured":"Mantel N, Haenszel WS. Statistical aspects of the analysis of data from retrospective studies of disease. J7 Natl Cancer Inst 1959;22:719-48.","journal-title":"J7 Natl Cancer Inst"},{"key":"ref_7","first-page":"690","article-title":"Chi-square tests for one degree of freedom; extensions of the Mantel-Haenszel procedure. J'Am Stat Assoc","volume":"58","author":"Mantel, N.","year":"1963","unstructured":"Mantel N. Chi-square tests for one degree of freedom; extensions of the Mantel-Haenszel procedure. J'Am Stat Assoc 1963;58:690-700."},{"key":"ref_8","article-title":"The GLIM system, release 3. Numerical Algorithms Group","author":"Baker, R.J.; Nelder, J.A.","year":"1978","unstructured":"Baker RJ, Nelder JA. The GLIM system, release 3. Numerical Algorithms Group, Oxford, 1978."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/oxfordjournals.humrep.a136188","article-title":"Induced abortions and risk of ectopic pregnancy","volume":"10","author":"Parazzini, F.; Ferraroni, M.; Tozzi, L.; Ricci, E.; Mezzopane, R.; La Vecchia, C.","year":"1995","unstructured":"Parazzini F, Ferraroni M, Tozzi L, Ricci E, Mezzopane R, La Vecchia C. Induced abortions and risk of ectopic pregnancy. Hum Reprod 1995;10:1841-4.","journal-title":"Hum Reprod"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0090-8258(91)90003-N","article-title":"The epidemiology of ovarian cancer","volume":"43","author":"Parazzini, F.; Franceschi, S.; La Vecchia, C.; Fasoli, M.","year":"1991","unstructured":"Parazzini F, Franceschi S, La Vecchia C, Fasoli M. The epidemiology of ovarian cancer. Gynecol Oncol 1991;43: 9-23.","journal-title":"Gynecol Oncol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1001\/jama.1986.03370140102032","article-title":"The relation of endometriosis to menstrual characteristics, smoking, and exercise","volume":"255","author":"Cramer, D.W.; Wilson, E.; Stillman, R.J.","year":"1986","unstructured":"Cramer DW, Wilson E, Stillman RJ, et al. The relation of endometriosis to menstrual characteristics, smoking, and exercise. JAMA 1986;255:1904-8.","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/00006250-198812000-00008","article-title":"Epidemiologic characteristics of women with uterine fibroids: a case-control study","volume":"72","author":"Parazzini, F.; La Vecchia, C.; Negri, E.; Cecchetti, G.; Fedele, L.","year":"1988","unstructured":"Parazzini F, La Vecchia C, Negri E, Cecchetti G, Fedele L. 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Epidemiol Community Health 1995;49: 61-4.","journal-title":"Epidemiol Community Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/oxfordjournals.aje.a113860","article-title":"Risk factors for pathologically confirmed benign breast disease","volume":"120","author":"Parazzini, F.; La Vecchia, C.; Franceschi, S.","year":"1984","unstructured":"Parazzini F, La Vecchia C, Franceschi S, et al. Risk factors for pathologically confirmed benign breast disease. 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