{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:54:56Z","timestamp":1791107696595,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>STUDY OBJECTIVE: To determine incidence of the following malignancies, testicular tumours, all leukaemias and all lymphomas in the West of Ireland in an 11 year period. Secondly, to examine the relation between disease patterns and available occupational data in male subjects of working age. DESIGN: A census survey of all cases occurring in the three counties in the Western Health Board (WHB) area, Galway, Mayo and Roscommon, for the 11 year period 1980 to 1990 inclusive. Average annual age standardised incidence rates for the period were calculated using the 1986 census data. Rates for the area are compared with rates from the southern region of Ireland, which had a tumour registry. Trends over the time period are evaluated. All male subjects for whom occupational data were available were categorised using the Irish socioeconomic group classification and incidence rates by occupation were compared using the standardised incidence ratio method. In one of the counties, Galway, a detailed occupational history of selected cases and an age matched control group was also elicited through patients' general practitioners. SETTING: All available case records in the West of Ireland. RESULTS: There are no national incidence records for the period. Compared with data from the Southern Tumour Registry, the number of cases of women with myeloid leukaemias was significantly lower. Male leukaemia rates were significantly lower as a group (SIR 84 (95% CI 74, 95) but not when considered as individual categories. Regression analysis revealed an increasing trend in the number of new cases of non-Hodgkin's lymphoma among both men (r = 0.47, p = 0.02) and women (r = 0.90, p = 0.0001) and of chronic lymphocytic leukaemia in men (r = 0.77, p = 0.005) and women (r = 0.68 p = 0.02) in the WHB region over the last decade. Four hundred and fifty six male cases over the age of 15 years were identified and adequate occupational information was available for 74% of these. Standardised incidence ratios of testicular tumours 100, 938) and agriworkers other than farmers (SIR 377, 95% CI 103, 967). There were also significantly increased incidence ratios for both non-Hodgkin's lymphoma (SIR 169, 95% CI 124, 266) and three categories of leukaemias among farmers. Hodgkin's disease and acute myeloid leukaemias were significantly increased among semi-skilled people. Interview data with 90 cases and 54 controls of both sexes revealed that among farmers, cases (n = 31) were significantly less likely than controls (n = 20) to use tractor mounted spraying techniques (OR = 0.19 (95% CI 0.04, 0.80)) and less likely to wear protective masks (OR 0.22 (95% CI 0.05, 0.84)). CONCLUSIONS: Trends of increase in non-Hodgkin's lymphoma and some leukaemias are consistent with studies elsewhere. The study provides further evidence of the relation between agricultural work and certain lymphoproliferative cancers. The possible carcinogenic role of chemicals used in agricultural industries must be considered as an explanation.<\/jats:p>","DOI":"10.1136\/jech.52.10.651","type":"journal-article","created":{"date-parts":[[2009,1,5]],"date-time":"2009-01-05T14:15:53Z","timestamp":1231164953000},"page":"651-656","source":"Crossref","is-referenced-by-count":15,"title":["Incidence and occupational pattern of leukaemias, lymphomas, and testicular tumours in western Ireland over an 11 year period."],"prefix":"10.1136","volume":"52","author":[{"given":"C","family":"Kelleher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Newell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"MacDonagh-White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"MacHale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Shryane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"ref_1","article-title":"Ireland and the EC","author":"Herity, B.; Hynes, M.; Cancer, Barry J.","year":"1991","unstructured":"Herity B, Hynes M, Barry J. Cancer, Ireland and the EC. Dublin: Royal College of Physicians of Ireland, 1991."},{"key":"ref_2","article-title":"Economic statistics","author":"of Ireland, Central Bank","year":"1992","unstructured":"Central Bank of Ireland. Economic statistics. Dublin: Central Bank, 1992."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF02937224","article-title":"Monoclonal gammopathies in the West of Ireland: a preliminary study","volume":"154","author":"Greally, J.; O\u2019Toole, G.; McCann, H.","year":"1985","unstructured":"Greally J, O\u2019Toole G, McCann H, et al. Monoclonal gammopathies in the West of Ireland: a preliminary study. Ir J Med Sci 1985;154:94\u2013101.","journal-title":"Ir J Med Sci"},{"key":"ref_4","first-page":"276","article-title":"Lymphoproliferative diseases in the West of Ireland: an epidemiological study","volume":"78","author":"Fitzgerald, J.; O\u2019Flanagan, F.; Egan, E.","year":"1985","unstructured":"Fitzgerald J, O\u2019Flanagan F, Egan E, et al. Lymphoproliferative diseases in the West of Ireland: an epidemiological study. Ir Med J 1985;78:276\u20138.","journal-title":"Ir Med J"},{"key":"ref_5","article-title":"Cancer: the Irish experience. The epidemiology of cancer in Southern Ireland","author":"J, Crowley M.","year":"1995","unstructured":"Crowley M J. Cancer: the Irish experience. The epidemiology of cancer in Southern Ireland. Cork: Statistical Laboratory, University College Cork, 1995."},{"key":"ref_6","article-title":"Census of population: small area population statistics. Dublin: Central Statistics OYce, Stationery OYce","year":"1987","unstructured":"Census of population: small area population statistics. Dublin: Central Statistics OYce, Stationery OYce, 1987."},{"key":"ref_7","first-page":"205","article-title":"A note on a proposed census based Irish social class scale for epidemiological health research","volume":"13","author":"O\u2019Hare, A.","year":"1982","unstructured":"O\u2019Hare A. A note on a proposed census based Irish social class scale for epidemiological health research. Economic and Social Review 1982;13:205\u201316.","journal-title":"Economic and Social Review"},{"key":"ref_8","article-title":"Childhood leukaemia in the Republic of Ireland mortality and incidence","author":"Daly, L.; Herity, B.","year":"1986","unstructured":"Daly L, Herity B. Childhood leukaemia in the Republic of Ireland mortality and incidence. Dublin: Department of Health, 1986."},{"key":"ref_9","first-page":"5432","article-title":"Non-Hodgkins lymphoma time trends. United States and international data","volume":"52","author":"Devesa, S.S.; Frears, T.","year":"1992","unstructured":"Devesa SS, Frears T. Non-Hodgkins lymphoma time trends. United States and international data. Cancer Res Suppl 1992;52:5432\u201340.","journal-title":"Cancer Res Suppl"},{"key":"ref_10","first-page":"583","article-title":"Reversibility of lymphomas and lymphoproliferative lesions devleoping under cytosporin-steroid therapy","volume":"i:","author":"E, Starr T.; MA, Nalesnik; KA, Porter","year":"1984","unstructured":"Starr T E, Nalesnik MA, Porter KA. Reversibility of lymphomas and lymphoproliferative lesions devleoping under cytosporin-steroid therapy. Lancet 1984;i:583\u20137.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-108-5-744","article-title":"Lymphoid neoplasia associated with AIDS. The New York University Medical Centre. Experience with 105 patients","volume":"108","author":"Knowles, D.M.; Chamulak, G.A.; Subar, M.","year":"1981","unstructured":"Knowles DM, Chamulak GA, Subar M. Lymphoid neoplasia associated with AIDS. The New York University Medical Centre. Experience with 105 patients (1981\u20131986). Ann Intern Med 1988;108:744\u201353.","journal-title":"Ann Intern Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(94)91167-3","article-title":"Epstein-Barr virus persistence and virus associated tumours","volume":"343","author":"Niedobitek, G.; Young, L.S.","year":"1994","unstructured":"Niedobitek G, Young LS. Epstein-Barr virus persistence and virus associated tumours. 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Scand J Work Environ Health 1985;11:397\u2013407.","journal-title":"Scand J Work Environ Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0046-8177(93)90234-8","article-title":"Human health eVects of agrichemical use","volume":"24","author":"Weisenburger, D.D.","year":"1993","unstructured":"Weisenburger DD. Human health eVects of agrichemical use. Hum Pathol 1993;24:571\u20136.","journal-title":"Hum Pathol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/1097-0142(19891201)64:11<2381::AID-CNCR2820641131>3.0.CO;2-M","article-title":"Cancer risks among Missouri farmers","volume":"64","author":"Brownson, R.C.; Reif, J.S.; Chang, J.C.","year":"1989","unstructured":"Brownson RC, Reif JS, Chang JC, et al. Cancer risks among Missouri farmers. 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J Epidemiol Community Health 1986;40:218\u201322.","journal-title":"J Epidemiol Community Health"},{"key":"ref_23","first-page":"225","article-title":"Occupational associations of testicular cancer in South East England","volume":"45","author":"Swerdlow, A.J.; Skeet, R.G.","year":"1988","unstructured":"Swerdlow AJ, Skeet RG. Occupational associations of testicular cancer in South East England. Br J Ind Med 1988;45:225\u201330.","journal-title":"Br J Ind Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJM199502023320510","article-title":"Are semen quality and male fertility changing?","volume":"332","author":"Sherins, R.J.","year":"1995","unstructured":"Sherins RJ. Are semen quality and male fertility changing? N Engl J Med 1995;332:327.","journal-title":"N Engl J Med"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0140-6736(84)92125-1","article-title":"Testicular cancer associated with employment in agriculture, oil and natural gas extraction","volume":"i:","author":"Mills, P.; Newell, G.R.; Johnson, D.E.","year":"1984","unstructured":"Mills P, Newell GR, Johnson DE. Testicular cancer associated with employment in agriculture, oil and natural gas extraction. Lancet 1984;i:207\u20139.","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ajim.4700190307","article-title":"Occupation and the occurrence of testicular cancer","volume":"19","author":"den Eeden SK, Van; NS, Weiss; CH, Strader","year":"1991","unstructured":"Van den Eeden SK, Weiss NS, Strader CH, et al. Occupation and the occurrence of testicular cancer. Am J Ind Med 1991;19:327\u201337.","journal-title":"Am J Ind Med"},{"key":"ref_27","article-title":"A study of dichlorovos (Nuvan 2,2, dichloro ethynl dimethyl phosphate) a therapeutic agent for sealice (Lepeophtlemus salmosis). Report no14","author":"Cusack, R.; Johnson, G.","year":"1989","unstructured":"Cusack R, Johnson G. A study of dichlorovos (Nuvan 2,2, dichloro ethynl dimethyl phosphate) a therapeutic agent for sealice (Lepeophtlemus salmosis). Report no14. Nova Scotia, Canada: ERDA, 1989."}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.52.10.651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:24:34Z","timestamp":1759494274000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.52.10.651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1998,10,1]]},"published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1136\/jech.52.10.651"],"URL":"https:\/\/doi.org\/10.1136\/jech.52.10.651","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"value":"0143-005X","type":"print"},{"value":"1470-2738","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}