{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:29:36Z","timestamp":1791214176951,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>\n                  <jats:bold>Study objectives:<\/jats:bold> To study the hospitalised incidence of Crohn\u2019s disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Analysis of linked data on hospital admissions; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC; and a comparison of these results with those from previous studies on the association between measles vaccine and CD or UC.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Settings:<\/jats:bold> Southern England.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Subjects:<\/jats:bold> People admitted to hospital with a main diagnosis of CD (1959 people) or UC (2018 people).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main results:<\/jats:bold> Overall, the incidence of hospitalised CD showed no significant change over the 20 year period: the average change per year was 0.08% (95% confidence interval: \u22120.7% to 0.9%). The relative risk associated with the measles vaccination programme was not significant (0.91: 0.5 to 1.4). The estimate differed significantly from the relative risk of 3.0 obtained in the original study reporting an association, but agreed with the combined estimate from three subsequent studies (0.95: 0.6 to 1.5). The results for UC were similar.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> The incidence of hospitalised CD and UC remained stable over the 20 years, 1979 to 1998. Whatever caused the marked increases in CD and UC in the mid-20th century must itself have stabilised in this region. These results, together with those from other studies, provide strong evidence against measles vaccine causing CD or UC.<\/jats:p>","DOI":"10.1136\/jech.57.11.883","type":"journal-article","created":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T18:36:54Z","timestamp":1067971014000},"page":"883-887","source":"Crossref","is-referenced-by-count":21,"title":["Crohn\u2019s disease, ulcerative colitis, and measles vaccine in an English population, 1979\u20131998"],"prefix":"10.1136","volume":"57","author":[{"given":"V","family":"Seagroatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Goldacre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,11,4]]},"reference":[{"key":"2025100520564217000_57.11.883.1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/gut.42.3.309","volume":"42","year":"1998","journal-title":"Gut"},{"key":"2025100520564217000_57.11.883.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90816-1"},{"key":"2025100520564217000_57.11.883.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03192-9"},{"key":"2025100520564217000_57.11.883.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03288.x"},{"key":"2025100520564217000_57.11.883.5","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archpedi.155.3.354","volume":"155","year":"2001","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2025100520564217000_57.11.883.6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/24.5.922"},{"key":"2025100520564217000_57.11.883.7","unstructured":"Numerical Algorithms Group. 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