{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:30:11Z","timestamp":1767648611121,"version":"build-2065373602"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Epidemiol Community Health"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Analysis of a database of linked hospital records and death certificates.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> The Oxford Region of the National Health Service, England.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Subjects:<\/jats:bold> A cohort comprising all people in the database with MS, and comparison cohorts of people with other diseases.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Skin cancer was significantly less common in people with MS than in the main comparison cohort (rate ratio 0.49; 95% confidence interval 0.24 to 0.91). There was no general deficit of cancer in the MS cohort, and no deficit of skin cancer in cohorts of people with other autoimmune or neurological diseases.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> The findings support the hypothesis that solar radiation may have a protective influence on the development of MS.<\/jats:p>","DOI":"10.1136\/jech.58.2.142","type":"journal-article","created":{"date-parts":[[2004,1,16]],"date-time":"2004-01-16T21:33:06Z","timestamp":1074288786000},"page":"142-144","source":"Crossref","is-referenced-by-count":64,"title":["Skin cancer in people with multiple sclerosis: a record linkage study"],"prefix":"10.1136","volume":"58","author":[{"given":"M J","family":"Goldacre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Seagroatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Yeates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E D","family":"Acheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,1,16]]},"reference":[{"key":"2025100521364116000_58.2.142.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1960.tb08674.x"},{"key":"2025100521364116000_58.2.142.2","first-page":"118","volume":"15","year":"1961","journal-title":"Brit J Prev Soc Med"},{"key":"2025100521364116000_58.2.142.3","first-page":"1","volume":"17","year":"1967","journal-title":"Neurology"},{"key":"2025100521364116000_58.2.142.4","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.10.669"},{"key":"2025100521364116000_58.2.142.5","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research, volume II. The design and analysis of cohort studies. IARC scientific publication no 82. Lyon: International Agency for Research in Cancer, 1987:103\u00e2\u0080\u009315."},{"key":"2025100521364116000_58.2.142.6","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199710000-00005"},{"key":"2025100521364116000_58.2.142.7","doi-asserted-by":"publisher","DOI":"10.1159\/000054782"},{"key":"2025100521364116000_58.2.142.8","doi-asserted-by":"publisher","DOI":"10.1159\/000054783"},{"key":"2025100521364116000_58.2.142.9","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.6.418"},{"key":"2025100521364116000_58.2.142.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7410.316"}],"container-title":["Journal of Epidemiology and Community Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech.58.2.142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:36:49Z","timestamp":1759725409000},"score":1,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech.58.2.142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,16]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,1,16]]},"published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1136\/jech.58.2.142"],"URL":"https:\/\/doi.org\/10.1136\/jech.58.2.142","relation":{},"ISSN":["0143-005X","1470-2738"],"issn-type":[{"type":"print","value":"0143-005X"},{"type":"electronic","value":"1470-2738"}],"subject":[],"published":{"date-parts":[[2004,1,16]]}}}