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We examined the main issues involved in extended use of the COC and how it has evolved from being one of medicine's best-kept secrets to becoming more widely accepted by women and the medical community.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study design<\/jats:title>\n                  <jats:p>Literature review, using Medline, Embase, Pubmed, CINHAL Plus, the Cochrane Database of Systematic Reviews and the Ovid database for all relevant clinical trials, systematic reviews, meta-analyses, literature reviews, scientific papers and individual opinions between 1950 and October 2013.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Accumulating evidence supports various forms of extended pill use as suitable alternatives to the standard (21\/7) regimen. In terms of user preference, much hinges on whether women wish to reduce the frequency or duration of scheduled bleeding on the combined pill. Available data on the safety of extended pill regimens do not give cause for concern, but longer term data should be collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Information for women considering extended COC regimens should keep pace with research findings to ensure that women and clinicians are better informed about the choices available.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jfprhc-2013-100600","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T10:51:23Z","timestamp":1395226283000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Evolution of extended use of the combined oral contraceptive pill"],"prefix":"10.1136","volume":"40","author":[{"given":"Sabeena","family":"Panicker","sequence":"first","affiliation":[{"name":"Specialist Registrar in Obstetrics & Gynaecology, Sexual and Reproductive Health Research Group, Institute for Women's Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Mann","sequence":"additional","affiliation":[{"name":"Consultant, Kings College Hospital, London; Clinical Research Associate, Sexual and Reproductive Health Research Group, Institute for Women's Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Shawe","sequence":"additional","affiliation":[{"name":"Senior Research Associate, Sexual and Reproductive Health Research Group, Institute for Women's Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Margaret Pyke Professor of Sexual & Reproductive Health, Sexual and Reproductive Health Research Group, Institute for Women's Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"2025090510030792000_40.2.133.1","doi-asserted-by":"publisher","DOI":"10.3109\/13625187.2010.513071"},{"issue":"(S2)","key":"2025090510030792000_40.2.133.2","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.3109\/13625187.2010.523485","article-title":"50th Anniversary of the pill \u2013 what does this story teach us?","volume":"15","author":"Bitzer","year":"2010","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"2025090510030792000_40.2.133.3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.contraception.2007.06.004","article-title":"To bleed or not to bleed, that is the question","volume":"76","author":"Coutinho","year":"2007","journal-title":"Contraception"},{"key":"2025090510030792000_40.2.133.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00524-4"},{"key":"2025090510030792000_40.2.133.5","doi-asserted-by":"crossref","unstructured":"Edelman AB Gallo MF Jensen JT . 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