{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:18:44Z","timestamp":1792401524425,"version":"4.4.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Few studies, and with controversial results, analyzed vitamin D status in children before and after growth hormone (GH) treatment. Thus, we aimed to assess vitamin D status in prepubertal children with idiopathic growth hormone deficiency (GHD), and to evaluate the effect of GHD and GH treatment on vitamin D levels. Fifty prepubertal children with isolated GHD were compared with 50 controls. All were subjected to history, anthropometric assessment and measurement of 25 hydroxyvitamin D (25(OH)D), serum calcium, phosphorous, alkaline phosphatase and parathyroid hormone (PTH) at diagnosis and 1\u2009year after GH therapy. Serum 25(OH)D levels &lt;30\u2009ng\/mL and 20\u2009ng\/mL were defined as vitamin D insufficiency and deficiency, respectively. 25(OH)D was lower in cases than controls. Forty per cent of children with GHD were 25(OH)D insufficient and 44% deficient, while 16% were sufficient at baseline. There was a positive correlation between 25(OH)D and peak GH levels. Peak GH was a significant predictor of 25(OH)D levels. After 1\u2009year of GH therapy, 25(OH)D increased (18.42\u00b15.41 vs 34.5\u00b110.1\u2009ng\/mL; P&lt;0.001). Overall, 22% of cases remained insufficient and 24% deficient, with an increase in prevalence of children with normal levels (54%; P&lt;0.001). 25(OH) correlated negatively with PTH (r=\u22120.71, P=0.01). In conclusion, hypovitaminosis D is prevalent in children with GHD and significantly improved 1\u2009year after GH therapy. 25(OH)D should be assessed in children with GHD at diagnosis and during follow-up.<\/jats:p>","DOI":"10.1136\/jim-2017-000618","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T20:10:36Z","timestamp":1519503036000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Vitamin D Status in Prepubertal Children with Isolated Idiopathic Growth Hormone Deficiency: Effect of Growth Hormone Therapy"],"prefix":"10.1177","volume":"66","author":[{"given":"Rasha Tarif","family":"Hamza","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira I","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud T","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, National Research Center, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"bibr1-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1099"},{"key":"bibr2-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32834ec952"},{"key":"bibr3-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.117185"},{"key":"bibr4-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"bibr5-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0084-7"},{"key":"bibr6-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12268"},{"key":"bibr7-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6984"},{"key":"bibr8-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1136\/adc.41.219.454"},{"key":"bibr9-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601473"},{"key":"bibr10-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"bibr11-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105357"},{"key":"bibr12-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.5.355"},{"key":"bibr13-jim-2017-000618","first-page":"83","volume":"14","author":"Babson AL","year":"1991","journal-title":"J Clin Immunoassy"},{"key":"bibr14-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211456"},{"key":"bibr15-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(01)80088-X"},{"key":"bibr16-jim-2017-000618","unstructured":"Tietz L. Clinical guide to laboratory tests. 4th edn. Philadelphia: Saunders WB Company, 2006:852\u20135."},{"key":"bibr17-jim-2017-000618","first-page":"494","volume-title":"Clinical methods","author":"David HV","year":"1990","edition":"3"},{"key":"bibr18-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195909000-00030"},{"key":"bibr19-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1390454"},{"key":"bibr20-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.05.003"},{"key":"bibr21-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021651"},{"key":"bibr22-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00586-3"},{"key":"bibr23-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.028"},{"key":"bibr24-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr25-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2014.0015"},{"key":"bibr26-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000204"},{"key":"bibr27-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1413"},{"key":"bibr28-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-009-9038-6"},{"key":"bibr29-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021787"},{"key":"bibr30-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27049"},{"key":"bibr31-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1996.tb02056.x"},{"key":"bibr32-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.76.2.8432773"},{"key":"bibr33-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.57"},{"key":"bibr34-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3188"},{"key":"bibr35-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02901.x"},{"key":"bibr36-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02601.x"},{"key":"bibr37-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.78.2.7508949"},{"key":"bibr38-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.69.817.846"},{"key":"bibr39-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030126"},{"key":"bibr40-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.3.8772587"},{"key":"bibr41-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2364"},{"key":"bibr42-jim-2017-000618","doi-asserted-by":"publisher","DOI":"10.4008\/jcrpe.v1i2.43"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jim-2017-000618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1136\/jim-2017-000618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jim-2017-000618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:42:21Z","timestamp":1777459341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1136\/jim-2017-000618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1136\/jim-2017-000618"],"URL":"https:\/\/doi.org\/10.1136\/jim-2017-000618","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}