{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:37:53Z","timestamp":1777725473012,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005570","name":"Takeda Pharmaceuticals North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials.gov identifier: NCT01654276), 24 patients with gouty arthritis and hyperuricemia were treated for 6 months with the xanthine oxidase inhibitor febuxostat to lower serum UA to &lt;6\u2009mg\/dL. Measurements of 24\u2009hours ambulatory blood pressure (ABP) and serum and urine markers of the metabolic syndrome were measured at baseline and at the end of 6 months of febuxostat. The study population consisted of 18 men and 6 women, 18 of which completed the baseline and 6\u2009months visits. Serum UA decreased significantly from 8.7\u00b11.5\u2009mg\/dL at baseline to 4.4\u00b11.1\u2009mg\/dL at 6 months (P&lt;0.0001). During that time frame, there was no significant change in body mass index, systolic or diastolic blood pressure measured by 24\u2009hours ABP monitor, serum glucose, insulin or homeostatic model assessment for insulin resistance, serum total and high-density lipoprotein-cholesterol, serum triglycerides or urine pH (P&gt;0.05 for all). There was no correlation between parameters of the metabolic syndrome and the decline in serum UA or serum UA achieved at study end. In conclusion, in patients with gouty arthritis, UA lowering with febuxostat below 6\u2009mg\/dL had no significant impact on features of the metabolic syndrome.<\/jats:p>","DOI":"10.1136\/jim-2018-000728","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T02:15:09Z","timestamp":1522894509000},"page":"1031-1036","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Pharmacological Reversal of Hyperuricemia on Features of the Metabolic Syndrome in Patients with Gouty Arthritis"],"prefix":"10.1177","volume":"66","clinical-trial-number":[{"clinical-trial-number":"nct01654276","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01654276","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Mariana","family":"Marin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Divisions of Mineral Metabolism and Endocrinology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naim M","family":"Maalouf","sequence":"additional","affiliation":[{"name":"Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, and Division of Mineral Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 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