{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:39:19Z","timestamp":1777725559908,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p&lt;0.001), but the level was not different between the CHC group and the controls (p&lt;0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p&lt;0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p&lt;0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p&lt;0.001) and CHC (r=0.59; p&lt;0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.<\/jats:p>","DOI":"10.1136\/jim-2018-000840","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:55:11Z","timestamp":1541033711000},"page":"681-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus"],"prefix":"10.1177","volume":"67","author":[{"given":"Ali","family":"Sobhy","sequence":"first","affiliation":[{"name":"Clinical Pathology Department., Faculty of Medicine, Al-Azhar University, Assiut, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhry M.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Faculty of Medicine., Al-Azhar University, Assiut."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Azeem","family":"Haitham","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M","family":"Ashmawy","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Omar Khalifa","sequence":"additional","affiliation":[{"name":"Public Health andCommunity Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, 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