{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:39:04Z","timestamp":1777725544724,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kyungpook National University research fund, 2013"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    We aimed to evaluate the changes in plasma membrane Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -ATPase (PMCA) and sarcoendoplasmic reticulum CA\n                    <jats:sup>2+<\/jats:sup>\n                    -ATPase (SERCA-2) according to the antepartal magnesium sulfate (MgSO\n                    <jats:sub>4<\/jats:sub>\n                    ) administration in the placentas from pregnancies with pre-eclampsia (PE) or fetal growth restriction (FGR). Pregnant women were classified as follows: (group 1) pregnancies without PE or FGR (n=16), (group 2) pregnancies with PE or FGR but without MgSO\n                    <jats:sub>4<\/jats:sub>\n                    administration (n=14), and (group 3) pregnancies with PE or FGR and with MgSO\n                    <jats:sub>4<\/jats:sub>\n                    administration (n=28). We observed the localization of PMCA and SERCA-2 in placentas and compared its expression among 3 groups. And we observed its expression in BeWo cells following treatment with MgSO\n                    <jats:sub>4<\/jats:sub>\n                    and CoCl\n                    <jats:sub>2<\/jats:sub>\n                    . PMCA staining was more observed in the basal membrane, whereas SERCA-2 staining was observed predominantly under the microvillous membrane. SERCA-2 expression was significantly increased in group 3 compared with that in group 1. Considering the gestational age at delivery, PMCA expression was increased in group 2 and group 3 compared with that in group 1 after 36 weeks of gestation. SERCA-2 was increased in group 3, but not in group 2 compared with that in group 1 after 36 weeks of gestation. In BeWo cells, MgSO\n                    <jats:sub>4<\/jats:sub>\n                    treatment increased PMCA and SERCA-2 expression. PMCA expression was influenced by gestational age at delivery, and SERCA-2 expression was increased in the presence of PE and antepartal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    administration. This indicates that antepartal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    administration has a greater influence on SERCA-2 than PMCA.\n                  <\/jats:p>","DOI":"10.1136\/jim-2018-000844","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:42:35Z","timestamp":1541810555000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction"],"prefix":"10.1177","volume":"67","author":[{"given":"Hyun-Hwa","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Ryoung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Sungkynkwan University School of Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk-Joo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheong-Rae","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"bibr1-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.12.003"},{"key":"bibr2-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.06.010"},{"key":"bibr3-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.01.002"},{"key":"bibr4-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.06.003"},{"key":"bibr5-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01039.x"},{"key":"bibr6-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0941"},{"key":"bibr7-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2012.690058"},{"key":"bibr8-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2014.973038"},{"key":"bibr9-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1076\/apab.108.4.380.4300"},{"key":"bibr10-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.12.012"},{"key":"bibr11-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.08.002"},{"key":"bibr12-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2003.03156.x"},{"key":"bibr13-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.156"},{"key":"bibr14-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2010.12.002"},{"key":"bibr15-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00994.2004"},{"key":"bibr16-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500073050"},{"key":"bibr17-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.039966"},{"key":"bibr18-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000146536.68208.84"},{"key":"bibr19-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600756896"},{"key":"bibr20-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2014.19.3.146"},{"key":"bibr21-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108319159"},{"key":"bibr22-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/597357"},{"key":"bibr23-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.252.1.C38"},{"key":"bibr24-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(06)50004-X"},{"key":"bibr25-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200007000-00012"},{"key":"bibr26-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.4.R930"},{"key":"bibr27-jim-2018-000844","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.10303"}],"container-title":["Journal 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