{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:30:56Z","timestamp":1793035856457,"version":"4.5.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Tseng-Lien Lin Foundation"},{"name":"Academia Sinica Stroke Biosignature Project","award":["BM10701010021"],"award-info":[{"award-number":["BM10701010021"]}]},{"DOI":"10.13039\/100010792","name":"Tungs' Taichung MetroHarbor Hospital","doi-asserted-by":"publisher","award":["TTMHH-109R0010"],"award-info":[{"award-number":["TTMHH-109R0010"]}],"id":[{"id":"10.13039\/100010792","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MOST Clinical Trial Consortium for Stroke","award":["MOST 107-2321-B-039 -004-"],"award-info":[{"award-number":["MOST 107-2321-B-039 -004-"]}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW108-TDU-B-212-133004"],"award-info":[{"award-number":["MOHW108-TDU-B-212-133004"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Katsuzo and Kiyo Aoshima Memorial Funds"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Hyperuricemia has been identified as an independent risk factor for coronary artery disease (CAD), with a dose-response association. In this study, we explored the causal association between gout and antigout medication and the risk of incidental CAD. We sampled data from the National Health Insurance Research Database and recruited 37,091 patients as the gout cohort, and 37,091 controls. Our primary endpoint was the diagnosis of CAD during follow-up. The overall study population was followed up until CAD diagnosis, withdrawal from the National Health Insurance program, or the end of the study. Cox proportional hazards regression models were used to examine the effect of gout on the risk of CAD, represented by the HR with the 95% CI. Patients with gout were at greater risk of CAD, compared with those without gout: HR=1.49 after adjusting for potential confounders. Non-steroidal anti-inflammatory drugs and prednisolone use was associated with a reduced risk of CAD: HR=0.63\u2009and 0.50, respectively. Patients with gout, treated with antigout medication, exhibited a reduced risk of CAD compared with non-gout patients. Among patients with gout, those on antigout therapy had 32% lower risk compared with those not on antigout therapy: adjusted HR=0.68, 95%\u2009CI 0.63 to 0.73. Gout increases the risk of CAD, and the use of antigout medication reduces CAD risk. These results indicate that gout or hyperuricemia is a modifiable risk factor for CAD.<\/jats:p>","DOI":"10.1136\/jim-2019-001140","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T06:15:13Z","timestamp":1582611313000},"page":"972-979","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of Gout with Cad and Effect of Antigout Therapy on Cvd Risk among Gout Patients"],"prefix":"10.1177","volume":"68","author":[{"given":"Wei-Shih","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chon-Haw","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-0068","authenticated-orcid":false,"given":"Kuang-Hsi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tungs\u2019 Taichung Metroharbor Hospital, Taichung City, Taiwan"},{"name":"Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"General Education Center, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"bibr1-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(02)00143-1"},{"key":"bibr2-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800885"},{"key":"bibr3-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1186\/ar2761"},{"key":"bibr4-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-34-6-1421"},{"key":"bibr5-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.11.094"},{"key":"bibr6-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027817"},{"key":"bibr7-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1186\/ar3322"},{"key":"bibr8-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-1-199907060-00003"},{"key":"bibr9-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-6-201203200-00006"},{"key":"bibr10-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.086"},{"key":"bibr11-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.110"},{"key":"bibr12-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90143-I"},{"key":"bibr13-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16087058"},{"key":"bibr14-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050373"},{"key":"bibr15-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1186\/ar3684"},{"key":"bibr16-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1038\/srep19520"},{"key":"bibr17-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.09.035"},{"key":"bibr18-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.074"},{"key":"bibr19-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.03.043"},{"key":"bibr20-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-008-0039-0"},{"key":"bibr21-jim-2019-001140","unstructured":"Database NHIR. Available: http:\/\/nhird.nhri.org.tw\/en\/index.html"},{"key":"bibr22-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.001"},{"key":"bibr23-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162645"},{"key":"bibr24-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0642-1"},{"key":"bibr25-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.2018.37.2.130"},{"key":"bibr26-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.07.034"},{"key":"bibr27-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2013.09.011"},{"key":"bibr28-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37562016000200001"},{"key":"bibr29-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.109884"},{"key":"bibr30-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90952-5"},{"key":"bibr31-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr048"},{"key":"bibr32-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(89)90061-9"},{"key":"bibr33-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117479"},{"key":"bibr34-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00198-0"},{"key":"bibr35-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00423-8"},{"key":"bibr36-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/s1047-2797(99)00037-x"},{"key":"bibr37-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3343"},{"key":"bibr38-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1038\/348730a0"},{"key":"bibr39-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1038\/nature742"},{"key":"bibr40-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283257b96"},{"key":"bibr41-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.12.019"},{"key":"bibr42-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi879"},{"key":"bibr43-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000069700.62727.C5"},{"key":"bibr44-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00170.2002"},{"key":"bibr45-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1016\/s1047-2797(96)00052-x"},{"key":"bibr46-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015352"},{"key":"bibr47-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1038\/nature01991"},{"key":"bibr48-jim-2019-001140","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31827d8790"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jim-2019-001140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1136\/jim-2019-001140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jim-2019-001140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:37:02Z","timestamp":1777459022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1136\/jim-2019-001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1136\/jim-2019-001140"],"URL":"https:\/\/doi.org\/10.1136\/jim-2019-001140","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}