{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:07:45Z","timestamp":1777723665121,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K23HD092588"],"award-info":[{"award-number":["K23HD092588"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Child Maternal Health CCTSI Pilot Award","award":["UL1TR002535"],"award-info":[{"award-number":["UL1TR002535"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1R56DK088971"],"award-info":[{"award-number":["1R56DK088971"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1S10OD018435"],"award-info":[{"award-number":["1S10OD018435"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23 RR020038"],"award-info":[{"award-number":["K23 RR020038"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK063687"],"award-info":[{"award-number":["T32 DK063687"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["11-2010-343"],"award-info":[{"award-number":["11-2010-343"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pediatric Endocrine Society Clinical Scholar Award"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Klinefelter syndrome (XXY) occurs in 1 in 600 males, resulting in testosterone deficiency and a high prevalence of insulin resistance. Testosterone deficiency in men is a known cause of insulin resistance, and mitochondrial dysfunction is hypothesized to mediate this relationship. The aim of this cross-sectional study was to evaluate muscle mitochondrial function in XXY compared with male controls. Twenty-seven boys with XXY (age 14.7\u00b11.8 years) were compared with 87 controls (age 16.9\u00b10.9). In-vivo calf muscle mitochondrial function was assessed via phosphorus magnetic resonance spectroscopy (\n                    <jats:sup>31<\/jats:sup>\n                    P-MRS) following 90\u2009s of isometric 70% maximal exercise. Multiple linear regression was used to compare\n                    <jats:sup>31<\/jats:sup>\n                    P-MRS outcomes (ADP and phosphocreatine (PCr) time constants, rate of oxidative phosphorylation (Oxphos), and Q\n                    <jats:sub>max<\/jats:sub>\n                    or the maximal mitochondrial function relative to mitochondrial density) between groups after adjusting for age differences. There were no statistically significant differences in the mitochondrial outcomes of ADP, Oxphos, PCr, and Q\n                    <jats:sub>max<\/jats:sub>\n                    between the groups. There were also no differences in a sensitivity analysis within the XXY group by testosterone treatment status. In this study, in-vivo postexercise skeletal muscle mitochondrial function does not appear to be impaired in adolescents with XXY compared with controls and is not significantly different by testosterone treatment status in XXY.\n                  <\/jats:p>","DOI":"10.1136\/jim-2021-001966","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T11:56:50Z","timestamp":1631015810000},"page":"104-107","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["In-vivo Skeletal Muscle Mitochondrial Function in Klinefelter Syndrome"],"prefix":"10.1177","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-9169","authenticated-orcid":false,"given":"Stephanie","family":"Cung","sequence":"first","affiliation":[{"name":"University of Colorado Denver School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA"},{"name":"Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Dabelea","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA"},{"name":"Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-1695","authenticated-orcid":false,"given":"Melanie","family":"Cree-Green","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanlee M","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA"},{"name":"eXtraordinarY Kids Clinic and Research Program, Children's Hospital Colorado, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"bibr1-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Davis S, Howell S, Wilson R, Advances in the interdisciplinary care of children with Klinefelter syndrome. Adv Pediatr 2016;63:15\u201346.doi:10.1016\/j.yapd.2016.04.020http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27426894","DOI":"10.1016\/j.yapd.2016.04.020"},{"key":"bibr2-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Granato S, Barbaro G, Di GiorgioMR, Epicardial fat: the role of testosterone and lipid metabolism in a cohort of patients with Klinefelter syndrome. Metabolism 2019;95:21\u20136.doi:10.1016\/j.metabol.2019.03.002http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30878494","DOI":"10.1016\/j.metabol.2019.03.002"},{"key":"bibr3-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Accardo G, Amoresano Paglionico V, Di Fraia R, Management of cardiovascular complications in Klinefelter syndrome patients. Expert Rev Endocrinol Metab 2019;14:145\u201352.doi:10.1080\/17446651.2019.1584036http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30793993","DOI":"10.1080\/17446651.2019.1584036"},{"key":"bibr4-jim-2021-001966","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16747.1"},{"key":"bibr5-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Lizarazo AH, McLoughlin M, Vogiatzi MG. Endocrine aspects of Klinefelter syndrome. Curr Opin Endocrinol Diabetes Obes 2019;26:60\u20135.doi:10.1097\/MED.0000000000000454http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30507702","DOI":"10.1097\/MED.0000000000000454"},{"key":"bibr6-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Shiraishi K, Matsuyama H. Klinefelter syndrome: from pediatrics to geriatrics. Reprod Med Biol 2019;18:140\u201350.doi:10.1002\/rmb2.12261http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30996677","DOI":"10.1002\/rmb2.12261"},{"key":"bibr7-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Salzano A, Arcopinto M, Marra AM, Klinefelter syndrome, cardiovascular system, and thromboembolic disease: review of literature and clinical perspectives. Eur J Endocrinol 2016;175:R27\u201340.doi:10.1530\/EJE-15-1025http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26850445","DOI":"10.1530\/EJE-15-1025"},{"key":"bibr8-jim-2021-001966","doi-asserted-by":"crossref","unstructured":"Calogero AE, Giagulli VA, Mongio\u00ec LM, Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders. 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