{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:08:56Z","timestamp":1777723736088,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity. Our goal was to explore the cardiac safety and clinical efficacy of long-term domperidone, titrated as high as 120 mg\/day, in patients not responding or unable to tolerate other therapies for gastroparesis (GP).This retrospective cohort study was conducted at a single tertiary care academic center. We objectively assessed the safety and efficacy of domperidone through questionnaires, clinical follow-up and frequent ECGs as mandated by the Food and Drug Administration. We excluded patients with a history of dangerous arrhythmias, prolonged QTc, clinically significant electrolyte disturbances, gastrointestinal hemorrhage or obstruction, presence of a prolactinoma, pregnant or breastfeeding females, or allergy to domperidone. A total of 21 patients met the inclusion criteria for eligibility in this study (52.4% white, 42.9% Hispanic; mean age 50.1 years; 90.5% female). The mean duration of domperidone therapy was 52.3 (range 16\u201397) months with a mean highest dose of 80 mg\/day (range 40\u2013120\u2009mg). Two patients (9.5%) taking 120 mg\/day experienced asymptomatic meaningful QTc prolongation (&gt;450\u2009ms in males, &gt;470\u2009ms in females). One-third of patients had asymptomatic non-meaningful QTc prolongation. Palpitations or chest pain was reported in 19% of patients without ECG abnormalities or adverse cardiac events. The mean severity of vomiting and nausea was improved by 82% and 55%, respectively.Long-term treatment with high doses of domperidone (40\u2013120\u2009mg\/day) improved GP symptoms in patients previously refractory to other medical therapies and with a satisfactory cardiovascular risk profile.<\/jats:p>","DOI":"10.1136\/jim-2021-001968","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T11:15:26Z","timestamp":1645787726000},"page":"1225-1232","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms"],"prefix":"10.1177","volume":"70","author":[{"given":"Kevin","family":"Woods","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-4848","authenticated-orcid":false,"given":"Mahesh","family":"Gajendran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"},{"name":"Department of Gastroenterology, UT Health San Antonio Long School of Medicine, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorisadday","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bustamante-Bernal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Espino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"bibr1-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.054"},{"key":"bibr2-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00760.x"},{"key":"bibr3-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.1.34"},{"key":"bibr4-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.373"},{"key":"bibr5-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01255.x"},{"key":"bibr6-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1080\/21678707.2019.1617694"},{"key":"bibr7-jim-2021-001968","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.055"},{"key":"bibr8-jim-2021-001968","unstructured":"Soykan I, Sarosiek I, McCallum RW. 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