{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:43:27Z","timestamp":1791283407639,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01HS024277"],"award-info":[{"award-number":["R01HS024277"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Our objective was to describe community-acquired pneumonia (CAP) among patients \u226585 years and compare them to patients aged 65\u201374. This was a retrospective cohort study. The study setting included 638 hospitals in the USA participating in the Premier database from 2010 to 2015. The study participants were 488,382 adults aged \u226565 years hospitalized with CAP. Patients \u226585 years were more likely to be white (79.8% vs 76.2%), female (58.1% vs 48.3%), and admitted with aspiration pneumonia (17.1% vs 7.0%) as compared with those aged 65\u201375 years. They had higher rates of dementia (30.4% vs 7.8%), but lower rates of diabetes (11.2% vs 17.6%) and chronic obstructive pulmonary disease (25.5% vs 54.7%). While Staphylococcus aureus (33.4%) was the most common pathogen across all age groups, patients aged \u226585 were more likely to have Escherichia coli pneumonia (16.1% vs 10.7%) compared with those aged 65\u201374. In adjusted models, patients aged \u226585 had greater in-hospital mortality (OR 1.14, 95% CI 1.11 to 1.18), but were less likely to be admitted to the intensive care unit (OR 0.54, 95% CI 0.53 to 0.55) and receive mechanical ventilation (OR 0.47, 95% CI 0.46 to 0.48). They also had lower rates of acute kidney injury (OR 0.95, 95% CI 0.91 to 1.00) and Clostridium difficile infection (OR 0.91, 95% CI 0.85 to 0.99), shorter lengths of stay (mean multiplier 0.93, 95% CI 0.92 to 0.93) and lower cost (mean multiplier 0.81, 95% CI 0.80 to 0.81), and were more likely to be discharged to a skilled nursing facility (OR 2.19, 95% CI 2.15 to 2.24) or hospice (OR 2.19, 95% CI 2.11 to 2.27). In conclusion, patients aged \u226585 have different comorbidities and etiologies of CAP, receive less intense treatment, and have greater mortality than patients between 65 and 75 years.<\/jats:p>","DOI":"10.1136\/jim-2021-002078","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T13:30:11Z","timestamp":1635255011000},"page":"376-382","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment and Outcomes among Patients \u226585 Years Hospitalized with Community-Acquired Pneumonia"],"prefix":"10.1177","volume":"70","author":[{"given":"Radhika","family":"Rastogi","sequence":"first","affiliation":[{"name":"The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeshir Z","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana J","family":"Herzig","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"},{"name":"Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Rothberg","sequence":"additional","affiliation":[{"name":"Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"bibr1-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix647"},{"key":"bibr2-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1086\/425615"},{"key":"bibr3-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt288"},{"key":"bibr4-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.6.2103038"},{"key":"bibr5-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17202000"},{"key":"bibr6-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00064102"},{"key":"bibr7-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122247"},{"key":"bibr8-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1783-9"},{"key":"bibr9-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-485"},{"key":"bibr10-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.796"},{"key":"bibr11-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2877"},{"key":"bibr12-jim-2021-002078","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.5430"},{"key":"bibr13-jim-2021-002078","unstructured":"Healthcare cost and utilization project, 2017. 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