{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:15:32Z","timestamp":1789643732648,"version":"4.0.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Fibromyalgia is characterized by diffuse musculoskeletal pain and fatigue. There are limited data about systemic steroid treatment of patients with fibromyalgia in the English literature. Patients with fibromyalgia with ongoing diffuse musculoskeletal pain despite standard treatment, extreme fatigue and elevated C-reactive protein (CRP) levels without evidence of synovitis, or other source of inflammation, were asked to participate in our study. After consent, demographic, clinical and laboratory parameters in addition to body mass index were documented. These patients were interviewed and asked to answer the Revised Fibromyalgia Impact Questionnaire (FIQR) just prior, 1 and 4 weeks following 14 mg depot betamethasone intramuscular injection. Twenty-three patients were recruited and 21 completed the study. 19 patients were women with mean age of 42\u00b110.12\u2009and CRP level of 14.1\u00b13.96\u2009mg%, and all had negative rheumatoid factor and antinuclear antibodies. All patients had significant improvement in all of the FIQR parameters, at 1 and 4 weeks, except memory, anxiety and balance. It can be concluded that systemic intramuscular depot betamethasone injection seems to have a favorable effect in patients with fibromyalgia with elevated CRP levels for at least 4 weeks.<\/jats:p>","DOI":"10.1136\/jim-2021-002293","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:15:51Z","timestamp":1654085751000},"page":"1553-1556","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of intramuscular depot betamethasone injection in patients with fibromyalgia and elevated C-reactive protein levels"],"prefix":"10.1177","volume":"70","author":[{"given":"Nageb","family":"Dirawi","sequence":"first","affiliation":[{"name":"Medicine, Laniado Hospital, Netanya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-8575","authenticated-orcid":false,"given":"George","family":"Habib","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic, Nazareth Hospital, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel"},{"name":"Rheumatology Unit, Laniado Hospital, Netanya, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"bibr1-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6584753"},{"key":"bibr2-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.11.014"},{"key":"bibr3-jim-2021-002293","unstructured":"Demirbag BC, Bulut A. Demographic characteristics, clinical findings and functional status in patients with fibromyalgia syndrome. J Pak Med Assoc 2018;68:1043\u20137.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30317299"},{"key":"bibr4-jim-2021-002293","unstructured":"Ablin JN, Oren A, Cohen S, Prevalence of fibromyalgia in the Israeli population: a population-based study to estimate the prevalence of fibromyalgia in the Israeli population using the London fibromyalgia epidemiology study screening questionnaire (LFESSQ). Clin Exp Rheumatol 2012;30:39\u201343.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23191939"},{"key":"bibr5-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.01.001"},{"key":"bibr6-jim-2021-002293","unstructured":"Fietta P. Fibromyalgia: state of the art. Minerva Med 2004;95:35\u201347.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15041925"},{"key":"bibr7-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.06.005"},{"key":"bibr8-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04621-5"},{"key":"bibr9-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0556-x"},{"key":"bibr10-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"bibr11-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1007\/BF02337009"},{"key":"bibr12-jim-2021-002293","doi-asserted-by":"publisher","DOI":"10.1016\/S2255-5021(13)70045-2"},{"key":"bibr13-jim-2021-002293","unstructured":"Danda D, Shyam Kumar NK, Cherian R, Enthesopathy: clinical recognition and significance. 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