{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:09:57Z","timestamp":1777723797276,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"French Ministry of Health (Programme Hospitalier de Recherche Clinique).","award":["PHRC 2008- A00680e55"],"award-info":[{"award-number":["PHRC 2008- A00680e55"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Lymphopenia is common in patients with sepsis and associated with mortality. Immune-stimulatory therapies likely to restore T-cells count and function are under investigation in sepsis. Our study aimed to assess whether lymphopenia is a reliable prognostic biomarker in Staphylococcus aureus bacteremia. We conducted an ancillary study of the prospective VIRSTA Study including 574 patients with S. aureus bacteremia in two tertiary care centers. Neither lymphocyte count at the onset nor lymphocyte change during the first 4\u2009days was associated with 12-week mortality. These results highlight the importance of characterizing the immune profile of patients with sepsis according to the cause before investigating immunostimulatory therapies to restore lymphocyte proliferation and function.<\/jats:p>","DOI":"10.1136\/jim-2022-002356","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T11:40:14Z","timestamp":1653910814000},"page":"1549-1552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Is blood lymphocyte count a prognostic biomarker in\n                    <i>Staphylococcus aureus<\/i>\n                    bacteremia?"],"prefix":"10.1177","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-2434","authenticated-orcid":false,"given":"Mathieu","family":"Blot","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Dijon Bourgogne University Hospital, Dijon, 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of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chirouze","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Besan\u00e7on Bourgogne University Hospital, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Bouiller","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Besan\u00e7on Bourgogne University Hospital, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Piroth","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dijon Bourgogne University Hospital, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"bibr1-jim-2022-002356","volume":"27","author":"Torres LK","year":"2021","journal-title":"Annu Rev 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