{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:20:56Z","timestamp":1767676856121},"reference-count":0,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Investig Med"],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:sec><jats:title \/><jats:p>Nine patients with sickle cell disease (SCD) who were hospitalized at UC Davis Medical Center for vaso-occlusive crisis (VOC) were studied as part of a randomized double-blind phase III clinical trial to investigate the real-time effects of poloxamer 188 on VOC. All patients showed significant microvascular changes from normal (steady-state) values during VOC (diminished venular diameter and red cell velocity). The patients were randomly assigned to be treated with poloxamer 188 or placebo. Poloxamer 188 (<jats:italic>n<\/jats:italic> = 4) but not placebo (<jats:italic>n<\/jats:italic> = 5) significantly reversed these microvascular changes \u02dc 2 hours postinitiation of loading infusion (100 mg\/kg in 1 hour). Further significant improvement induced by poloxamer 188 but not placebo was observed \u2265 7 hours postinfusion, resulting in a significant reversal of the microvascular changes to steady-state values.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jim-52-06-35","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T23:43:02Z","timestamp":1462923782000},"page":"402-406","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Poloxamer 188 Treatment on Sickle Cell Vaso-occlusive Crisis: Computer-Assisted Intravital Microscopy Study"],"prefix":"10.1177","volume":"52","author":[{"given":"Anthony T. W.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahana","family":"Ramanujam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Rangaswami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Curl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Wun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jim-52-06-35","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T12:38:51Z","timestamp":1672835931000},"score":1,"resource":{"primary":{"URL":"http:\/\/jim.bmj.com\/lookup\/doi\/10.1136\/jim-52-06-35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,1,4]]},"published-print":{"date-parts":[[2004,9,1]]}},"alternative-id":["10.1136\/jim-52-06-35"],"URL":"https:\/\/doi.org\/10.1136\/jim-52-06-35","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,1]]}}}