{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:00:36Z","timestamp":1792270836873,"version":"4.4.0"},"reference-count":29,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Immunother Cancer"],"accepted":{"date-parts":[[2020,7,24]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant and non-malignant diseases. So far, direct comparison of MDSC across different diseases and Centers is hindered by technical pitfalls and a lack of standardized methodology. To overcome this issue, we formed a network through the COST Action Mye-EUNITER (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.mye-euniter.eu\">www.mye-euniter.eu<\/jats:ext-link>) with the goal to standardize and facilitate the comparative analysis of human circulating MDSC in cancer, inflammation and infection. In this manuscript, we present the results of the multicenter study Mye-EUNITER MDSC Monitoring Initiative, that involved 13 laboratories and compared circulating MDSC subsets across multiple diseases, using a common protocol for the isolation, identification and characterization of these cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We developed, tested, executed and optimized a standard operating procedure for the isolation and immunophenotyping of MDSC using blood from healthy donors. We applied this procedure to the blood of almost 400 patients and controls with different solid tumors and non-malignant diseases. The latter included viral infections such as HIV and hepatitis B virus, but also psoriasis and cardiovascular disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed that the frequency of MDSC in healthy donors varied substantially between centers and was influenced by technical aspects such as the anticoagulant and separation method used. Expansion of polymorphonuclear (PMN)-MDSC exceeded the expansion of monocytic MDSC (M-MDSC) in five out of six solid tumors. PMN-MDSC expansion was more pronounced in cancer compared with infection and inflammation. Programmed death-ligand 1 was primarily expressed in M-MDSC and e-MDSC and was not upregulated as a consequence of disease. LOX-1 expression was confined to PMN-MDSC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides improved technical protocols and workflows for the multi-center analysis of circulating human MDSC subsets. Application of these workflows revealed a predominant expansion of PMN-MDSC in solid tumors that exceeds expansion in chronic infection and inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jitc-2020-001223","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T04:03:04Z","timestamp":1599624184000},"page":"e001223","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":194,"title":["Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation"],"prefix":"10.1136","volume":"8","author":[{"given":"Luca","family":"Cassetta","sequence":"first","affiliation":[{"name":"MRC Centre for Reproductive Health, The University of Edinburgh The Queen's Medical Research Institute, Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bruderek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Skrzeczynska-Moncznik","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Ma\u0142opolska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oktawia","family":"Osiecka","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Ma\u0142opolska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Hu","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg, Baden-W\u00fcrttemberg, Germany"},{"name":"Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Marie","family":"Rundgren","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Scientist Education and Chemical Engineering, Faculty of Engineering and Natural Sciences, Western Norway University of Applied Sciences, Bergen, Hordaland, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Stockholm, Stockholm, Sweden"},{"name":"Center for Molecular Medicine, Karolinska Institute, Stockholm, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Santegoets","sequence":"additional","affiliation":[{"name":"Medical Center, Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University, Nijmegen, Gelderland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Horzum","sequence":"additional","affiliation":[{"name":"Department of Basic Oncology, Cancer Institute, Hacettepe University, Ankara, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Godinho-Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, University of Lisbon, Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennadiy","family":"Zelinskyy","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Hospital Essen, Essen, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia","family":"Garcia-Tellez","sequence":"additional","affiliation":[{"name":"HIV Inflammation and Persistence, Pasteur Institute, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u010dica","family":"Bjelica","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Institute for Medical Research, University of Belgrade, Beograd, Beograd, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Taciak","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Institute of Biology, Warsaw University of Life Sciences, Warszawa, Poland"},{"name":"Cellis AG, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Olsnes","family":"Kittang","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, Bergen, Hordaland, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"H\u00f6ing","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dixon","sequence":"additional","affiliation":[{"name":"Edinburgh Breast Unit and Breast Cancer Now Research Unit, The University of Edinburgh, Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg, Baden-W\u00fcrttemberg, Germany"},{"name":"Department of 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia Evdoxia","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Hospital Essen, Essen, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Center for Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, CEA, Universit\u00e9 Paris-Sud, Saint-Aubin, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Badura","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, University of Lisbon, Lisboa, Lisboa, Portugal"},{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas, Northern Lisbon University Hospital Centre, Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-9265","authenticated-orcid":false,"given":"Monika","family":"Kapinska-Mrowiecka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Specialised Hospital of Stefan Zeromski in Krakow, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Gotic","sequence":"additional","affiliation":[{"name":"Clinic of Hematology, Clinical Center of Serbia, Beograd, Beograd, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"ter Laan","sequence":"additional","affiliation":[{"name":"Medical Center, Department of Neurosurgery, Radboud University, Nijmegen, Gelderland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kers-Rebel","sequence":"additional","affiliation":[{"name":"Medical Center, Radiotherapy & OncoImmunology Laboratory, Department of 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